Abstract: Objective To study the standardized peripherally inserted central catheter(PICC)maintenance rate at the intermission of chemotherapy and its influence factors,and to provide evidence for preventive intervention to increase of normative PICC maintenance rate. Methods A total of 120 cancer chemotherapy patients once discharged with PICC in treatment intermission from April,2014 to August,2015 in four municipal hospitals in Jinhua were chosen as research objects.Maintenance records of all patients were established.Patients completed maintenance record at the intermission of chemotherapy,and were surveyed PICC maintenance situation and complication via questionnaires.Normative PICC maintenance rate and ill-formed maintenance were analyzed,and influence factors on PICC maintenance of study group were analyzed by single factor and multi-factor methods. Results Standardized PICC maintenance rate was low,and normative maintenance rate of study group was 52.50%(63/120).Ill-formed maintenance included incomplete PICC case(7.50%),deficiency of self-observation and specialized examination(15.83%),incorrect method of sealing and fixing(10.00%),irregularity of maintenance and disinfection(25.83%),serious complication and improper drawing(18.33%).Single analysis revealed statistical differences in age,complication with T2DM,remaining time of PICC,temperature,D-Dimer between groups(P<0.05),and multi-analysis revealed that age(OR=3.467,95% CI:1.755-6.453),complication with T2DM(OR=5.225,95% CI:2.612-10.774),temperature(OR=2.596,95% CI:1.387-5.895)and D-Dimer(OR=7.515,95% CI:2.369-19.454)were independent influence factors. Conclusion Standardized PICC maintenance rate at the intermission of chemotherapy was low,and advanced age,fever and raise of D-Dime are supposed to be the risk factors of non-standard PICC maintenance,and preventive intervention should be taken to increase normative maintenance rate.