维持性血液透析患者发生骨质疏松的危险因素及其与血清钙、磷、甲状旁腺素的关系

沈英; 梁世凯

doi:10.16766/j.cnki.issn.1674-4152.2017.11.024

维持性血液透析患者发生骨质疏松的危险因素及其与血清钙、磷、甲状旁腺素的关系

doi: 10.16766/j.cnki.issn.1674-4152.2017.11.024

沈英^1, ,,
梁世凯²

1. 绍兴市中医院肾内科, 浙江绍兴 312000;
2. 浙江省人民医院肾内科, 浙江杭州 310002

基金项目:

2014年浙江省医药卫生一般研究计划 (2014KYA-014)

详细信息

通讯作者:
沈英,E-mail:173148827@qq.com

中图分类号: R459.5;R446.11
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出版历程
- 收稿日期: 2016-12-16
- 网络出版日期: 2022-08-06

Risk factors of osteoporosis in maintenance hemodialysis patients and its relationship with serum calcium,phosphorus and parathyroid hormon levels

SHEN Ying^{1
, ,},
LIANG Shi-kai²

Department of Nephrology, Shaoxing Traditional Chinese Medicine Hospital, Shaoxing, Zhejiang 312000, China

摘要

摘要: 目的观察维持性血液透析患者发生骨质疏松的危险因素及骨质疏松与血清钙、磷、甲状旁腺素的关系。方法选择绍兴市中医院肾内科2012年1月—2015年12月进行维持性血液透析患者200例进行研究，将其分为骨质疏松组93例，非骨质疏松组107例。收集患者的临床资料，测定患者的跟骨骨密度及血清钙、磷、甲状旁腺素水平。结果骨质疏松组患者男性比例(33.3%)低于非骨质疏松组(62.6%)(P<0.05)，骨质疏松组≥60岁患者比例(63.4%)高于非骨质疏松组(29.9%)(P<0.05)，骨质疏松组患者体重、身高、体重指数[(59.34±10.27) kg、(1.62±0.08) m、(20.89±1.34) kg/m²]均低于非骨质疏松组[(67.35±12.63) kg、(1.67±0.06) m、(22.14±2.54) kg/m²](P<0.05)。骨质疏松组血磷和甲状旁腺素水平(1.91±0.57) mmol/L、(381.34±77.36) ng/L均高于非骨质疏松组(1.64±0.52) mmol/L、(243.64±64.35) ng/L (P<0.05)，2组血钙比较差异无统计学意义(P>0.05)。Logistic回归分析显示：性别、年龄、血磷是维持性血液透析患者骨质疏松的独立影响因素(P<0.05)。女性、高龄、血磷升高是维持性血液透析患者骨质疏松的独立危险因素。维持性血液透析患者骨密度值与血清钙、磷、甲状旁腺素水平差异均无统计学意义(均P>0.05)。结论女性、高龄、高磷血症是维持性血液透析患者骨质疏松的独立危险因素，维持性血液透析患者的骨密度与血清钙、磷、甲状旁腺素水平无显著相关性。
- 维持性血液透析 /
- 骨质疏松 /
- 钙 /
- 磷 /
- 甲状旁腺素
Abstract: Objective To observe the risk factors of osteoporosis and the relationship between osteoporosis and serum calcium,phosphorus and parathyroid hormone levels in maintenance hemodialysis patients. Methods We selected 200 patients with maintenance hemodialysis in the Department of Nephrology of Shaoxing Traditional Chinese Medicine Hospital from January,2012 to December,2015 for the study.The 200 patients were divided into osteoporosis group(n=93) and non-osteoporosis group(n=107).The clinical data of the patients were collected and the calcaneus bone mineral density,serum calcium,phosphorus and parathyroid hormone levels were measured. Results The proportion of men in the osteoporosis group(33.3%) was lower than that in the non-osteoporosis group(62.6%,P<0.05).The proportion of patients older than 60 years(63.4%) in the osteoporosis group was higher than that in the non-osteoporosis group(29.9%,P<0.05).The body weight,height and body mass index of patients in the osteoporosis group[(59.34±10.27)kg,(1.62±0.08)m,(20.89±1.34)kg/m²] were significantly lower than those in the non-osteoporosis group[(67.35±12.63)kg,(1.67±0.06)m,(22.14±2.54)kg/m²],P<0.05.The levels of serum phosphorus and parathyroid hormone in osteoporosis group[(1.64±0.52)mmol/L,(243.64±64.35)ng/L] were higher than those in non-osteoporosis group[(1.91±0.57)mmol/L,(381.34±77.36)ng/L],P<0.05.There was no significant difference of blood calcium between the two groups(P>0.05).Logistic regression analysis showed that the gender,age and serum phosphorus were independent factors of osteoporosis in maintenance hemodialysis patients(P<0.05).Women,older age,elevated serum phosphorus were independent risk factor for osteoporosis in maintenance hemodialysis patients.There was no significant correlation between bone mineral density and calcium,phosphorus,and parathyroid hormone levels in maintenance hemodialysis patients(P>0.05). Conclusion Female,aged,hyperphosphatemia are independent risk factors for osteoporosis in maintenance hemodialysis patients.There is no significant correlation between bone mineral density and calcium,phosphorus and parathyroid hormone levels in maintenance hemodialysis patients.
- Maintenance hemodialysis /
- Osteoporosis /
- Calcium /
- Phosphorus /
- Parathyroid hormone