社区获得性肺炎患者可溶性E选择素水平变化情况及其意义

陈莹; 夏轶姿; 龚裕强; 陈刚

doi:10.16766/j.cnki.issn.1674-4152.2017.11.031

社区获得性肺炎患者可溶性E选择素水平变化情况及其意义

doi: 10.16766/j.cnki.issn.1674-4152.2017.11.031

陈莹^1, ,,
夏轶姿¹,
龚裕强²,
陈刚³

1. 温州医科大学附属第二医院急诊科, 浙江温州 325027;
2. 温州医科大学附属第二医院重症医学科;
3. 杭州师范大学附属医院呼吸科, 浙江杭州 310013

基金项目:

2010年浙江省医药卫生科技计划项目 (2010KYA-141)

详细信息

通讯作者:
陈莹,E-mail:15052958@qq.com

中图分类号: R563.1;R446.11
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出版历程
- 收稿日期: 2017-02-19
- 网络出版日期: 2022-08-06

Changes and its significance of soluble E-selectin in patients with community acquired pneumonia

Department of Emergency, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China

摘要

摘要: 目的探讨社区获得性肺炎(community acquired pneumonia，CAP)患者可溶性E选择素(sE-选择素)水平变化情况及其意义。方法选择重症CAP患者50例作为重症肺炎组、非重症CAP患者50例作为非重症肺炎组、健康体检者50例作为对照组，重症肺炎组分为多器官功能障碍组和非多器官功能障碍组。测定血清sE-选择素、C-反应蛋白、白细胞计数。结果血清sE-选择素、C-反应蛋白、白细胞计数在重症肺炎组、非重症肺炎组和对照组分别为(41.23±10.78) ng/ml、(85.47±21.14) ng/ml、(18.35±4.21)×10⁹/L；(13.25±3.84) ng/ml、(43.25±12.15) ng/ml、(12.01±2.87)×10⁹/L；(5.64±1.42) ng/ml、(2.12±0.89) ng/ml、(6.57±2.02)×10⁹/L，组间差异具有统计学意义(P<0.05)。血清sE-选择素在多器官功能障碍组和非多器官功能障碍组分别为(53.14±12.53) ng/ml和(37.28±8.21) ng/ml，组间差异具有统计学意义(P<0.05)。重症肺炎组患者治疗前和治疗后血清sE-选择素、C-反应蛋白、白细胞计数分别为(41.23±10.78) ng/ml、(85.47±21.14) ng/ml、(18.35±4.21)×10⁹/L；(18.74±5.84) ng/ml、(12.96±5.12) ng/ml、(8.83±2.52)×10⁹/L，组间差异具有统计学意义(P<0.05)。非重症肺炎组治疗前和治疗后血清sE-选择素、C-反应蛋白、白细胞计数分别为(13.25±3.84) ng/ml、(43.25±12.15) ng/ml、(12.01±2.87)×10⁹/L；(9.13±1.56) ng/ml、(9.16±2.04) ng/ml、(6.85±2.31)×10⁹/L，组间差异具有统计学意义(P<0.05)。肺炎患者血清sE-选择素与C-反应蛋白、白细胞计数均呈正相关(P<0.05)。结论 CAP患者血清sE-选择素水平升高，sE-选择素水平与CAP的严重程度及治疗效果有关。
- 社区获得性肺炎 /
- 可溶性E选择素 /
- C-反应蛋白
Abstract: Objective To investigate the changes of soluble E-selectin(sE-selectin) levels in patients with community acquired pneumonia and its significance. Methods We collected 50 patients with community-acquired severe pneumonia as severe pneumonia group,50 patients with community-acquired non-severe pneumonia as non-severe pneumonia group,and 50 healthy subjects as control group.The severe pneumonia group patients were divided into multiple organ dysfunction group and non-multiple organ dysfunction group.The serum sE-selectin,C-reactive protein,and white blood cell count were measured. Results The serum sE-selectin,C-reactive protein and white blood cell count in severe pneumonia group,non-severe pneumonia group and control group were (41.23±10.78)ng/ml,(85.47±21.14)ng/ml,(18.35±4.21)×10⁹/L;(13.25±3.84)ng/ml,(43.25±12.15)ng/ml,(12.01±2.87)×10⁹/L;(5.64±1.42)ng/ml,(2.12±0.89)ng/ml,(6.57±2.02)×10⁹/L,and the difference among the groups were significant(P<0.05).The serum sE-selectin in the multiple organ dysfunction group and non-multiple organ dysfunction group were (53.14±12.53)ng/ml and (37.28±8.21) ng/ml,with statistical significance among groups (P<0.05).The levels of serum sE-selectin,C-reactive protein and white blood cell count before and after treatment in severe pneumonia group were (41.23±10.78)ng/ml,(85.47±21.14)ng/ml,(18.35±4.21)×10⁹/L;(18.74±5.84)ng/ml,(12.96±5.12)ng/ml,(8.83±2.52)×10⁹/L respectively,and the difference between the two groups were significant(P<0.05).The serum sE-selectin,C-reactive protein and white blood cell count in the non-severe pneumonia group before and after treatment were (13.25±3.84)ng/ml,(43.25±12.15)ng/ml,(12.01±2.87)×10⁹/L;(9.13±1.56)ng/ml,(9.16±2.04)ng/ml,(6.85±2.31)×10⁹/L,and the difference between the two groups were significant(P<0.05).The serum sE-selectin was positively correlated with C-reactive protein and white blood cell count(P<0.05). Conclusion The serum sE-selectin level is elevated in patients with community-acquired pneumonia,and the serum sE-selectin level is associated with the severity of community-acquired pneumonia and the therapeutic effect.
- Community-acquired pneumonia /
- Soluble E-selectin /
- C-reactive protein