Abstract: Objective To investigate the effect of oxycodone hydrochloride injection on the recovery and hemodynamics in patients with general anesthesia for laparoscopic operation. Methods Total 95 patients undergoing laparoscopic abdominal surgery in Zhejiang Cancer Hospital between July,2015 and July,2016 were enrolled and randomly divided into observation group(49 cases) and control group(46 cases).Both groups received the same anesthesia induction and maintenance of anesthesia,postoperative discontinuation of remifentanil.The observation group was given 0.1 mg/kg oxycodone hydrochloride injection,while the control group received 1 mg/kg tramadol.The recovery,intraoperative hemodynamics,agitation sedation after extubation(RASS),pain score(VAS) and adverse reactions were compared between the two groups. Results There was no significant difference in the recovery time,time to extubation,time for the recovery of spontaneous breathing,and time for fully restored sanity between the two groups(P>0.05).The preoperative heart rate and mean arterial pressure before operation had no significant difference between the two groups(P>0.05).The heart rate and mean arterial blood pressure immediately after the operation,immediately after extubation,and 10 min after extubation were significantly higher than those before the operation in both groups(P<0.05),which were all obviously lower than those of the control group(P<0.05).The RASS score and VAS score of the observation group were significantly lower than those of the control group at 10,30,60 and 120 min after the extubation. Conclusion Oxycodone hydrochloride injection is helpful to hemodynamic stability of patients with general anesthesia for laparoscopic operation,with ideal postoperative analgesia which will decreased the incidence of agitation and ensure the quality of anesthesia during extubation.It is is worthy of clinical application.