Abstract: Objective To explore the clinical effect and prognostic factors of micro-incision phacoemulsification and aspheric intraocular lens on primary angle-closure glaucoma. Methods Ninety-five eyes of 89 cases admitted to our hospital from September,2014 to July,2016 were randomly divided into observation group(n=45,49 eyes) and control group(n=44,46 eyes).The observation group received micro-incision phacoemulsification combined with aspheric intraocular lens,while the control group received compound trabeculectomy.The best corrected visual acuity,intraocular pressure,anterior chamber depth and postoperative complications in the two groups were compared before and after the treatment,and the related factors affecting the treatment outcome were analyzed. Results After the treatment,the best corrected visual acuity and anterior chamber depth were significantly increased and the intraocular pressure decreased in both groups(P<0.05).The best corrected visual acuity and anterior chamber depth in the observation group were significantly higher than those in the control group,and intraocular pressure was significantly lower than that in the control group(t=5.391,P<0.001;t=-5.484,P<0.001;t=2.048,P=0.043).The incidence of postoperative complications in the observation group was 26.53%,which was lower than 32.61% in the control group,but there was no statistical difference between the two groups(χ²=0.422,P=0.516).The age,lens thickness and angle of attachment were the factors which associated with treatment outcome. Conclusion Micro-incision phacoemulsification combined with aspheric intraocular lens has a significant clinical efficacy in the treatment of primary angle-closure glaucoma,which can effectively improve the vision,deepen the anterior chamber depth,reduce intraocular pressure,with high safety.The age,lens thickness and angle of attachment are closely related to the treatment outcome.