Abstract: Objective To investigate the efficacy of TCM Pinggan Ditan prescription in treatment of severe preeclampsia and its effect on serum hs-CRP,Hcy,Apelin and LIF. Methods Total 158 patients with severe preeclampsia in our hospital between January,2015 and December,2016 were randomly divided into two groups with 79 cases in each group.The control group was given magnesium sulfate,and the observation group was given TCM Pinggan Ditan prescription.The blood gas indexes(SBP,DBP,HR),serum indexes(hs-CRP,Hcy,Apelin,LIF) of the two groups were compared. Results After the treatment,SBP and DBP levels of both groups were significantly decreased(P<0.05),and SBP and DBP levels of the observation group were lower than those of the control group(P<0.05).After the treatment,the serum hs-CRP and Hcy levels of both groups were significantly decreased(P<0.05),and hs-CRP and Hcy levels of the observation group were lower than those of the control group(P<0.05).After the treatment,the serum Apelin level of the two groups were significantly decreased(P<0.05),and Apelin level of the observation group were lower than that of the control group(P<0.05);the serum LIF level of both groups were significantly increased(P<0.05),and LIF level of the observation group were higher than that of the control group(P<0.05). Conclusion TCM Pinggan Ditan prescription is effective method for the severe preeclampsia and might play the role through regulating serum hs-CRP,Hcy,Apelin and LIF.