Abstract: Objective To investigate the ICU special nursing combined with oxygen atomizing inhalation effects on inflammatory factors in patients with severe pneumonia. Methods Eighty-six cases of severe pneumonia patients in our hospital ICU from August,2014 to August,2016 were selected and randomly divided into 2 groups.Forty-three cases in control group were treated with conventional ICU nursing and routine treatment,and 43 cases in experimental group were treated with conventional ICU nursing combined ICU special nursing and oxygen-driven aerosol inhalation therapy.Before and after treatment,the serum IL-6,CRP,TNF-α,metal matrix protein function,VC,FVC,FEV1,FEV1/FVC,and clinical symptoms disappearing time of two groups were observed.And the results were analyzed using statistical software SPSS 19.0. Results Compared with those before treatment,serum IL-6,CRP,TNF-α,MMP-9 of two groups were significantly decreased (P<0.05),VC,FVC,FEV1 and FEV1/FVC levels of two groups were significantly increased (P<0.05).Compared with those in the control group,serum TIMP-1 VC,FVC,FEV1 and FEV1/FVC of experimental group were significantly higher than those of control group (P<0.05),serum IL-6,CRP,TNF-α,MMP-9 levels and improving elapse of clinical symptoms of experimental group were significantly lower than those of control group (P<0.05). Conclusion ICU special nursing combined with oxygen atomizing inhalation could effectively reduce the serum IL-6,CRP,TNF-αof patients with severe pneumonia,improve lung function,reduce the time to improve clinical symptoms,and has better effect than conventional treatment.