中华全科医学

The restrictive factors and optimization of continuing medical education policy for general practitioners in China

WU Shuang, XI Biao

2023, 21(12): 1995-1999. doi: 10.16766/j.cnki.issn.1674-4152.003275

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Postgraduate medical education is an important part of the medical education system, and it plays an increasingly important role in enhancing the postgraduate competence of general practitioners (GP) and improving the level of grassroots medical services. At present, GP training in China is in the s...

The mediating role of loneliness and social support between stigma and social avoidance in rural breast cancer survivors

JIANG Mengfan, WANG Wanxia, GAO Jin, YANG Liu, QIAN Jing, LI Jinzhi

2023, 21(12): 2000-2004. doi: 10.16766/j.cnki.issn.1674-4152.003276

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Objective To explore the relationship between stigma and social avoidance in rural breast cancer survivors, and to analyze the moderating effect of social support in order to provide a theoretical basis for promoting social integration. Methods A total of 260 rural breast cancer survivors were selec...

Advances in the study of chemotherapy resistance mechanisms in breast cancer based on genomics perspective

CAI Lingyi, CHEN Tao, ZHANG Xiaolin, LI Zheyuan, ZHANG Niulin, KONG Lingqi, SHI Shangying, ZHANG Jingya, DU Fuquan, HAO JING

2023, 21(12): 2005-2008. doi: 10.16766/j.cnki.issn.1674-4152.003277

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Breast cancer, which became the cancer with the highest prevalence rate in the world for the first time in 2020, is one of the most common cancers in women. As a fast-growing invasive cancer, breast cancer has become a serious threat to women ' s health worldwide. Currently, the mainstay of breast c...

Clinical value of ultrasonography combined with shear wave elastography for the assessment of molecular subtypes of breast cancer

BI Weipei, SHI Yan, WANG Lingling, ZHANG Hui, CUI Zhen

2023, 21(12): 2009-2013. doi: 10.16766/j.cnki.issn.1674-4152.003278

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Objective To investigate the relationship between qualitative and quantitative parameters of contrast ultrasound combined with shear wave elastography and different molecular staging of breast cancer. Methods Fifty-two patients with suspected malignant lesions detected by mammography and/or routine ...

Effect of transauricular endoscopic tympanoplasty in the treatment of large tympanic membrane perforation

DONG Jianfei, DAI Yanhong, CHEN Jie, ZHOU Han, GAO Xia, LU Ling

2023, 21(12): 2014-2017. doi: 10.16766/j.cnki.issn.1674-4152.003279

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Objective To investigate the clinical effect of underlay (medial) tympanoplasty of "external auditory canal flap-tympanic annulus-residual tympanic membrane 360 degree full lift" under oto-endoscope for the treatment of large tympanic membrane perforation, and to introduce the key points and techniq...

The relationship between CD13 expression and clinicopathological parameters in gastric cancer and its predictive value for long term prognosis

ZHANG Chaoyang, YANG Zi, LI Hongtao, ZHANG Wenjing, ZHAO Meng, WANG Juan, ZUO Lugen, ZHANG Xiaofeng

2023, 21(12): 2018-2021. doi: 10.16766/j.cnki.issn.1674-4152.003280

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Objective To analyze the expression of alanyl (membrane) aminopeptidase (CD13) in gastric cancer tissues and its relationship with clinicopathological parameters, and to evaluate its value in predicting the long-term prognosis of patients with gastric cancer. Methods A total of 117 patients who unde...

Relationship between LMR, PNI and chemotherapy response and prognosis in patients with multiple myeloma

CHEN Xiaoshuang, GAO Zhengjie, GAO Panke, XING Rui, HAN Xiaolin, LI Jingdong

2023, 21(12): 2022-2026. doi: 10.16766/j.cnki.issn.1674-4152.003281

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Objective To investigate the effects of lymphocyte-monocyte ratio (LMR) and prognostic nutritional index (PNI) with chemotherapy response and prognosis in patients with multiple myeloma (MM). Methods A total of 243 MM patients admitted to the First Affiliated Hospital of Xinxiang Medical University ...

Clinical study of endoscopic rubber ring ligation combined with foam sclerosing agent injection in the treatment of internal hemorrhoids of grade Ⅱ to Ⅲ mixed hemorrhoids

YIN Kaihong, CHENG Yinmeng, ZHANG Tao, KE Xiquan, XU Feng, ZHAO Changdong

2023, 21(12): 2027-2030. doi: 10.16766/j.cnki.issn.1674-4152.003282

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Objective Exploring the clinical efficacy and safety analysis of endoscopic rubber band ligation (ERBL) combined with foam sclerotherapy (FS) in the treatment of mixed hemorrhoids of grade Ⅱ to Ⅲ. Methods A total of 62 patients who underwent mixed hemorrhoid treatment at the Department of Gastroente...

Value of systemic immune inflammation index in predicting the efficacy of first-line chemotherapy and survival outcome in patients with HER2 negative advanced gastric cancer

ZHOU Yangyang, LIU Jing, ZHU Yeqing, YANG Yan, ZHOU Zhengguang, WANG Mingxi

2023, 21(12): 2031-2035. doi: 10.16766/j.cnki.issn.1674-4152.003283

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Objective To explore the value of the systemic immune-inflammatory index (SII) in predicting the efficacy of first-line chemotherapy and survival in patients with human epidermal growth factor receptor 2 (HER2) negative advanced gastric cancer. Methods The clinical data of advanced gastric cancer pa...

Current status and influencing factors analysis of adverse reactions in hematopoietic stem cell infusion

CHENG Fang, SHEN Wangfang, HUANG Xinrui, ZHANG Yaohong, MAO Xiaopei

2023, 21(12): 2036-2039. doi: 10.16766/j.cnki.issn.1674-4152.003284

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Objective To investigate the current situation and influencing factors of adverse reactions of hematopoietic stem cell infusion, and to provide a basis for the construction of a safe infusion program for hematopoietic stem cells. Methods A total of 389 patients with hematological diseases who underw...

Effect of SFRP1 on the proliferation and invasion of head and neck squamous cell carcinoma and its mechanism

YANG Zhongyu, LI Wei, ZHU Guangzheng, ZHAO Wenyi, XU Jing

2023, 21(12): 2040-2044. doi: 10.16766/j.cnki.issn.1674-4152.003285

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Objective To observe the biological activities of head and neck squamous cell carcinoma (HNSC) in vitro by studying the proliferation, migration and mechanism of secreted frizzled related protein 1 (SFRP1), and to propose new therapeutic options for the treatment of HNSC. Methods The association of ...

Functional and mechanistic of TCF3 regulating linc00152 on carcinogenic effects in Burkitt's lymphoma

WEI Xiaofang, CHEN Qiaolin, FENG Youfan, FU Yuan, LIU Fei, ZHANG Wenjie, CHEN Yang, ZHAO Yangyang, HUANG Xiujuan, ZHANG Qike

2023, 21(12): 2045-2048. doi: 10.16766/j.cnki.issn.1674-4152.003286

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Objective To investigate the function and mechanism of TCF3 in regulating proliferation and apoptosis of Daudi and Raji cells through linc00152. Methods The interference efficiency of linc00152 was detected by real-time quantitative polymerase chain reaction (qPCR). CCK8, Western blotting, and flow ...

Clinical observation of the effect of cytomegalovirus infection on pertussis in infants

CHEN Leyuan, WANG Yao, HE Liting, PAN Jiahua, ZHANG Lan

2023, 21(12): 2049-2052. doi: 10.16766/j.cnki.issn.1674-4152.003287

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Objective To investigate the effect of cytomegalovirus (CMV) infection on the clinical presentation, duration of illness, and severity of illness in children with pertussis. Methods A retrospective analysis was conducted on 241 children with pertussis who were admitted to the paediatric ward of the ...

Correlation analysis between psychological health and treatment compliance in patients with chronic periodontitis

WU Yuanyuan, WANG Huimin, HE Ruanhui, ZHU Yesu

2023, 21(12): 2053-2056. doi: 10.16766/j.cnki.issn.1674-4152.003288

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Objective This study aims to analyze the current status of mental health and treatment compliance in patients with chronic periodontitis, while also investigating the correlation between the two factors. Methods This prospective study employed convenience sampling to enroll 86 patients with chronic ...

Study on the therapeutic effect of minimally invasive release under microscope combined with postoperative oral administration of Jiangu capsules on cubital tunnel syndrome

GAO Xing, MENG Yufeng, WANG Wei, LI Shiying, ZHANG Tongtong

2023, 21(12): 2057-2059. doi: 10.16766/j.cnki.issn.1674-4152.003289

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Objective To investigate the application effect of oral Jiangu capsules in minimally invasive release of elbow tunnel syndrome patients under microscope, It aims to provide reference for research on the treatment of the disease. Methods A total of 94 patients with cubital tunnel syndrome from Januar...

The role of sleep quality and anxiety-depression on preoperative pain catastrophizing and early postoperative pain in patients undergoing abdominal surgery

YAO Guomei, YAO Hongying, SHEN Yunxia, CAO Liying, JIN Chaojie

2023, 21(12): 2060-2063. doi: 10.16766/j.cnki.issn.1674-4152.003290

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Objective To explore the mediating effects of sleep quality, anxiety-depression on pain catastrophizing before surgery and early postoperative pain in patients undergoing abdominal surgery. The findings will contribute to the development of intervention programs aimed at reducing early postoperative...

Visual analysis of traditional Chinese medicine in the treatment of diabetic cardiomyopathy based on CiteSpace

ZHAO Qiyao, LI Jiaoyue, WEN Yalu, YUAN Ruyue, ZHANG Ye, HU Chaoyue, ZHANG Li, YANG Xiaohui

2023, 21(12): 2064-2067. doi: 10.16766/j.cnki.issn.1674-4152.003291

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Objective To analyze the literature related to the treatment of diabetic cardiomyopathy (DCM) with traditional Chinese medicine (TCM) over the past 30 years using CiteSpace software, and to sort out the research status, research hotspots and development trends in this field, so as to provide a refer...

Constructing a knowledge graph for health intervention in hypertension from the perspective of precise health management

GAO Ya, CHEN Ning, YUAN Ling, CHEN Hong, TAN Shuoyuan, HE Yibei, WU Qingyu, HOU Hongpan, WANG Zhaoxin, SHI Jianwei

2023, 21(12): 2068-2073. doi: 10.16766/j.cnki.issn.1674-4152.003292

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Objective Primary healthcare institutions face significant challenges in managing hypertension, necessitating practical and effective tools. Therefore, this study aims to construct a knowledge graph for hypertension health intervention offering valuable insights for precise health intervention. Meth...

Correlation between uterine artery SD, THBS1 and coagulation dysfunction in pregnant women with pre-eclampsia

ZHANG Xia, XU Xiaomin

2023, 21(12): 2074-2076. doi: 10.16766/j.cnki.issn.1674-4152.003293

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Objective To explore the relationship that may help in the treatment of pre-eclampsia by measuring the peak systolic flow rate/end-diastolic flow rate (SD) of uterine arteries in pregnant women with pre-eclampsia, platelet thrombin protein 1 (THBS1), and changes in coagulation indices. Methods A tot...

Analysis of influencing factors and establishment of nomogram model for pneumonia complications in children with infectious mononucleosis

YANG Xingxing, SHAN Mingfeng, MENG Hui

2023, 21(12): 2077-2080. doi: 10.16766/j.cnki.issn.1674-4152.003294

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Objective To develop a nomograph model for predicting pneumonia in children with infectious mononucleosis (IM), offering a valuable screening tool for identifying pneumonia in this population. Additionally, to assess the model' s ability to differentiate and maintain consistency in predicting pneumo...

Clinical use of a multifunctional reflective observation stool in midwifery

XIA Hongxia, XU Yuying, LEI Xia

2023, 21(12): 2081-2085. doi: 10.16766/j.cnki.issn.1674-4152.003295

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Objective Comparison of the clinical effectiveness of foreign-imported birthing stools and our department' s multi-functional reflective observation birthing stool for seated delivery. Methods A retrospective study was conducted on low-risk primiparous women who gave birth at Hangzhou First People' ...

Mediating effect of leptin levels between insulin resistance and nonalcoholic fatty liver disease in obese children

BAI Min, HUANG Lieping, ZHU Bei, WU Jinhua, WU Qiong, HONG Kaiting, YU Youna

2023, 21(12): 2086-2088. doi: 10.16766/j.cnki.issn.1674-4152.003296

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Objective Paediatric non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and its prevalence is increasing with the rise in overweight and obesity. Leptin was the first adipokine to be isolated and identified. Therefore, the mediating role of leptin levels b...

The significance of MemTrax in screening mild cognitive impairment in elderly diabetes patients in community

ZHU Wenkui, LIU Wei, XU Qun, QIAN Yahui, XU Qi

2023, 21(12): 2089-2092. doi: 10.16766/j.cnki.issn.1674-4152.003297

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Objective To explore the relevance of using the MemTrax (MTX) online cognitive memory assessment system for screening diabetes in older people in the community, providing a basis for clinical promotion. Methods From September to October 2022, 89 elderly diabetic patients and 62 non-diabetic patients...

Research on the influencing factors and countermeasures of depression among occupational women in functional communities based on IMB structural equation model

GAO Jing, JIANG Lianghua, NI Shuang, WU Huichao

2023, 21(12): 2093-2096. doi: 10.16766/j.cnki.issn.1674-4152.003298

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Objective To explore the factors influencing depression in working women in functional communities and to identify strategies to optimize and improve their level of self-management of depression. Methods Based on the literature review and expert consultation, a survey questionnaire was designed and ...

Effect of self-help mindfulness-based intervention on stigma and resilience in patients with depression

BI Hongsheng, DAI Jiali, SUN Dawei

2023, 21(12): 2097-2100. doi: 10.16766/j.cnki.issn.1674-4152.003299

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Objective Patients with depression have higher stigma and lower psychological resilience. Mindfulness intervention is one of the effective ways to reduce the stigma of patients with depression and improve their psychological resilience. This study used a self-help mindfulness course to intervene and...

Nursing effect of incentive health education combined with traditional Chinese medicine suitable technology in patients undergoing cesarean section

YAN Yanyan, HUANG Liuyan, CHEN Lifang, ZHAO Yi, CHENG Huifang

2023, 21(12): 2101-2105. doi: 10.16766/j.cnki.issn.1674-4152.003300

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Objective Applying motivational health education combined with appropriate technology of traditional Chinese medicine to cesarean section laboring women to explore the nursing effect. Methods The data of 150 cases of pregnant women undergoing cesarean delivery in Lishui Traditional Chinese Medicine ...

Prediction of IDH-1 mutation status in WHO grade Ⅱ and Ⅲ gliomas by radiomics combined with T₁-weighted contrast-enhanced image

ZHAO Shasha, XIN Yongkang, ZHANG Kai, WANG Ying, LIU Jinlin, YANG Yang, WANG Wen

2023, 21(12): 2106-2110. doi: 10.16766/j.cnki.issn.1674-4152.003301

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Objective To explore the diagnostic efficiency of T₁-weighted contrast-enhanced image (T₁CE) radiomic features and clinical-related parameters in predicting isocitrate dehydrogenase-1 (IDH-1) gene mutations in WHO grade Ⅱ and Ⅲ gliomas. Methods MRI data of 135 patients with WHO grade Ⅱ and Ⅲ gliomas...

Effect of Doppler ultrasound, CT and MRI in preoperative staging diagnosis of endometrial cancer

PAN Xuekui, ZHU Ling, SHAN Huaying, LU Yan

2023, 21(12): 2111-2113. doi: 10.16766/j.cnki.issn.1674-4152.003302

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Objective To investigate the application value of Doppler ultrasound, CT and MRI in the preoperative staging diagnosis of endometrial cancer, and to provide evidence for updating of clinical diagnostic methods. Methods From December 2019 to December 2021, 98 patients with endometrial cancer diagnose...

FAM134B-mediated endoplasmic reticulum autophagy and its association with diseases

ZHANG Yi, WEI Na

2023, 21(12): 2114-2118. doi: 10.16766/j.cnki.issn.1674-4152.003303

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Autophagy has the ability to degrade damaged senescent organelles and abnormal proteins, providing energy and raw materials for life activities. Autophagy is mainly divided into four stages, including the formation of autophagic precursors, autophagosomes, autophagic lysosomes and the degradation of...

Research progress on the cGAS-STING pathway in the kidney disease

HAN Zhenyuan, WANG Xiaoyan

2023, 21(12): 2119-2123. doi: 10.16766/j.cnki.issn.1674-4152.003304

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As an important component of the innate immune system, the cyclic guanosine monophosphate-adenosine monophosphate synthase stimulator of interferon genes (cGAS-STING) signaling pathway plays a critical role in mediating immune responses by inducing the secretion of type Ⅰ interferons and inflammator...

Research progress on the current situation of anesthesia nurse role pressure and intervention strategies

MA Shuning, ZHANG Anping, WANG Jing, LING Tao, CHEN Benzhen

2023, 21(12): 2124-2127. doi: 10.16766/j.cnki.issn.1674-4152.003305

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As a special group of specialized nurses, the development of anesthesia nurses has attracted wide attention at home and abroad. The research shows that the anesthesia nurses are under obvious role pressure due to the lack of staff ratio, work characteristics and obvious differentiation of responsibi...

Correlation between caries and body mass index and waist circumference in children aged 11 to 13 in Sichuan Province

SUN Taolan, YAN Xinmiao, LU Yuhang, TAN Xin, WANG Zhuo, LI Miaojing

2023, 21(12): 2128-2132. doi: 10.16766/j.cnki.issn.1674-4152.003306

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Objective To investigate the prevalence of dental caries and obesity in children aged 11-13 years in Sichuan Province, and to explore the relationship between dental caries and body mass index and waist circumference, in order to provide a reference for formulating intervention strategies for childh...

linical study on the treatment of urinary incontinence after prostatectomy with thunder fire moxibustion

CAI Qun, GUO Qin, HE Kelin, NIU Xuekang, GUO Fangfang, YUAN Kangni

2023, 21(12): 2133-2136. doi: 10.16766/j.cnki.issn.1674-4152.003307

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Objective To compare the clinical effect of thunder fire moxibustion (TFM) combined with pelvic floor muscle training and pelvic floor muscle training alone in the treatment of urinary incontinence after prostate surgery and its influence on patients' quality of life. Methods A total of 66 patients ...

The practical exploration of the team-based learning model in ICU clinical teaching under the guidance of multidisciplinary team collaboration

LI Zuotao, ZHONG Zhihong, LIU Yanquan, GUO Ling, XU Qinglin, WANG Yili

2023, 21(12): 2137-2140. doi: 10.16766/j.cnki.issn.1674-4152.003308

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Objective To analyze and explore the application effect of team-based learning (TBL) under the guidance of multi-disciplinary team (MDT) in intensive care unit (ICU) clinical teaching practice, and to explore a new way for ICU clinical teaching reform. Methods A total of 87 resident physicians in th...

A study on the implementation effect and influencing factors of the parallel training for master's degree in general practice and residency standardized training in Anhui Province

YU Haiyan, ZHONG Ping, WANG Wei, ZHU Chuanbo, YU Xianqing, WANG Haoyang, CHEN Ren, XIAO Jincheng

2023, 21(12): 2141-2144. doi: 10.16766/j.cnki.issn.1674-4152.003309

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Objective By investigating the implementation effect of the concurrent training model for master' s degree in general practice and standardized residency training, as well as the factors influencing core competence in Anhui Province, this study offers value insights to enhance the core competence of...

Comparative analysis of research status on general practice between China and overseas based on the Coronavirus disease 2019 literature

CHEN Xiaolei, SHAO Shuang, FENG Zhengwen, LI Hui, LUO Qi, ZHU Chenli, DU Juan

2023, 21(12): 2145-2150. doi: 10.16766/j.cnki.issn.1674-4152.003310

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Objective The purpose of this study was to understand the status of research in the field of general practice and the gaps with international research by analyzing the relevant published papers and providing a reference for future research. Methods The papers of general practice on Coronavirus disea...

Construction and implementation of a collaborative work system between designated hospitals and infection control departments during a local outbreak of Coronavirus disease 2019 infection

FAN Shanhong, XUE Hong, XU Wen, GE Wei, SHEN Li, DONG Yu, FU Ting, HE Zhen, GENG Jie

2023, 21(12): 2151-2155. doi: 10.16766/j.cnki.issn.1674-4152.003311

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Objective To explore the work system and operational mechanism of designated hospitals and infection control departments during local outbreaks of coronavirus disease 2019 (COVID-19) infection, so as to provide theoretical and practical references for the effective implementation of infection preven...

Implementation and evaluation of a multidisciplinary team-based model for managing and caring for elderly patients with traumatic hip fractures

XIONG Fei, SHAO Xiaoping, RUI Biyu

2023, 21(12): 2156-2159. doi: 10.16766/j.cnki.issn.1674-4152.003312

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Objective To investigate the impact of a multi-disciplinary team-based model on managing and caring for elderly patients with traumatic hip fractures, and analyze of surgical-related indicators, postoperative complications rate, and nursing satisfaction during the patient's hospitalization. Methods ...

The effect of therapeutic communication combined with routine care on sleep quality and psychological status of patients with obstructive sleep apnea syndrome

WANG Haiyan, ZHU Yazhen, PAN Yourang, YU Xiaoding, TAO Kewei

2023, 21(12): 2160-2164. doi: 10.16766/j.cnki.issn.1674-4152.003313

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Objective To observe the clinical application of routine care combined with therapeutic communication intervention in patients with obstructive sleep apnea syndrome (OSAS), and to analyze the impact of this plan on the quality of sleep and psychological status of the patients. Methods A total of 82 ...

Application of nursing model based on enhanced recovery after surgery concept combined with ear point embedding in the perioperative period of elderly hip fractures

YANG Chang, LUO Guogang, ZHOU Minjie

2023, 21(12): 2165-2168. doi: 10.16766/j.cnki.issn.1674-4152.003314

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Objective To investigate the effects of a medical care model based on the concept of enhanced recovery after surgery (ERAS) combined with ear point embedding on postoperative pain, negative emotions and sleep quality in elderly hip fracture patients. Methods Selected 200 elderly hip fracture patient...

Ustekinumab in the treatment of stenosis Crohn's disease: A case report and literature review

SHAO Xiaoxiao, SHI Ruixin, FANG Ye, WANG Weizhong, JIANG Yi

2023, 21(12): 2169-2172. doi: 10.16766/j.cnki.issn.1674-4152.003315

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Crohn's disease (CD) is a chronic granulomatous disease of unknown etiology that can affect any part of the alimentary tract from the mouth to the anus. CD is often accompanied by a variety of complications, such as intestinal lumen stenosis, intestinal fistula, abscess and perforation. Intestinal l...

Congenital portosystemic shunts: 2 cases report and review of literature

XU Jiaxin, DAI Liying, ZHANG Jian, WANG Juan, LIU Yu

2023, 21(12): 2173-2176. doi: 10.16766/j.cnki.issn.1674-4152.003316

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To increase clinicians' awareness of congenital portosystemic shunts, pay attention to the details of the child's medical history, achieve early detection and develop individualized treatment plans. Retrospective analysis of clinical data of 2 cases of CPSS in children seen and treated at Anhui Chil...

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2023 Vol. 21, No. 12

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