中华全科医学

Practice of family physician contracted service under the whole process health management model in tertiary a-level hospital

MU Xingyu, ZHANG Lin, AN Kang, SHI Yi, LI Caizheng, SHE Yi, LI Shuangqing, SU Qiaoli

2023, 21(7): 1085-1088. doi: 10.16766/j.cnki.issn.1674-4152.003055

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Objective The family physician contracted service has carried out beneficial practices in China's community health service centers. Most of the tertiary A-level hospitals take community health service centers as the main body, and cooperate with community units to provide technical guidance and know...

The effect and significance of cerebral infarction location on cognitive function

ZHAO Jianhua, ZHANG Jing, CAI Mengmeng, CHAO Linlin, SHI Jingjing, BAO Jieyu

2023, 21(7): 1089-1092. doi: 10.16766/j.cnki.issn.1674-4152.003056

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Objective To analyze the changes of clinical data and cognitive impairment in patients with cerebral infarction, and to evaluate the effect and significance of infarction location on cognitive function. Methods A total of 316 patients with acute cerebral infarction admitted to People's Hospital of Z...

Study on the correlation between miR-184 expression levels and disease severity, inflammatory factors in patients with acute cerebral infarction

SU Yan, LIU Kai, DU Yuanyuan, XIONG Bochao, LIANG Lei, LUO Song, QU Hongdang

2023, 21(7): 1093-1096. doi: 10.16766/j.cnki.issn.1674-4152.003057

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Objective To investigate the correlation between serum miR-184 levels and severity of disease and with inflammatory factors in patients with acute cerebral infarction (ACI). Methods A total of 74 ACI patients and 41 healthy individuals were included in the Neurology Department of the First Affiliate...

Effects of edaravone dexborneol combined with tirofiban on cerebral hemodynamics and oxidative stress in patients with acute cerebral infarction

HUANG Liangtong, XU Lingyan

2023, 21(7): 1097-1100. doi: 10.16766/j.cnki.issn.1674-4152.003058

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Objective In recent years, the incidence of acute cerebral infarction has been increased year by year. In order to find more effective methods for the treatment of acute cerebral infarction, this study used edaravone dexborneol combined with tirofiban in the treatment of patients with acute cerebral...

Analysis of circRNA and mRNA expression profiles in Alzheimer's disease mice treated with islet amyloid polypeptide

LI Xiaoxiong, LI Jinping, HUANG Jie, MA Jingjing, HOU Mingliang, MA Linqiu, WANG Congguo, ZHOU Huadong

2023, 21(7): 1101-1104. doi: 10.16766/j.cnki.issn.1674-4152.003059

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Objective To investigate the changes of circulating RNA (circRNA) and messenger RNA (mRNA) expression profiles in brain tissue of mice with Alzheimer's disease (AD) treated with islet amyloid polypeptide (IAPP) and the molecular mechanisms. Methods According to the number table method, 6 APP/PS1 mic...

Efficacy of cyclophosphamide combined with glucocorticoids therapy with different degrees of hematuria IgA nephropathy

SU Jili, ZHOU Xiaoshuang, FAN Xiuzhao, HAO Huiqiang, TIAN Shuangshuang, HUI Dongna, HAN Xiutao

2023, 21(7): 1105-1108. doi: 10.16766/j.cnki.issn.1674-4152.003060

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Objective To evaluate the effect of cyclophosphamide (CTX) combined with glucocorticoids (GS) in the treatment of primary IgA nephropathy (IgAN) with different degrees of hematuria, and provide reference for therapy of IgAN. Methods The clinical data of the primary IgAN patients treated with CTX and...

Expression of KLHL7 in non-small cell lung cancer and its clinical significance

HUANG Ting, GONG Huiyuan, TANG Zhen, LI Wei, ZHANG Lei, LI Xiaojun, GAO Xiong

2023, 21(7): 1109-1112. doi: 10.16766/j.cnki.issn.1674-4152.003061

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Objective To investigate the correlation between the expression of Kelch-like family member 7 (KLHL7) in non-small cell lung cancer (NSCLC) tissue and paracancerous tissue and the prognosis of NSCLC patients. Methods The difference of KLHL7 expression in NSCLC tissue and paracancerous tissue was ana...

Study on the changes of cortical excitability in patients with postherpetic neuralgia evaluated by transcranial magnetic stimulation

YANG Yiling, LI Yuee, ZHANG Junfeng, ZHANG Yun

2023, 21(7): 1113-1116. doi: 10.16766/j.cnki.issn.1674-4152.003062

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Objective To explore differences of cortical excitability assessed by transcranial magnetic stimulation (TMS) between patients with postherpetic neuralgia (PHN) and healthy controls, and to examine their relationships with pain symptoms severity. Methods A total of 30 PHN patients and 30 age-and sex...

Knockdown of EPHA2 regulates autophagy and biological behavior of bladder cancer cell through mTOR phosphorylation

ZHANG Yongqi, ZOU Zhenhai, WU Mengqi, LIU Beibei, GUO Yuanyuan, LIU Jianmin

2023, 21(7): 1117-1120. doi: 10.16766/j.cnki.issn.1674-4152.003063

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Objective To explore the molecular mechanism by which Si-EPHA2 interferes with the biological behaviour of bladder cancer cells by targeting mTOR autophagy pathways. Methods The expression levels of EPHA2 in bladder cancer tissues and paracancerous tissues, as well as bladder cancer cells (T24) and ...

Predictive value of NRS2002 and PNI nutritional screening methods in the prognosis of patients with gastric cancer

BA Minqing, CHEN Liu, ZHU Xiaoqiong, HU Kongwang, ZHAO Cunxi

2023, 21(7): 1121-1124. doi: 10.16766/j.cnki.issn.1674-4152.003064

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Objective To compare the predictive value of nutritional risk screening 2002 (NRS2002) and prognostic nutritional index (PNI) in the short-term prognosis of gastric cancer. Methods A total of 381 gastric cancer patients who attended Anhui Cancer Hospital and underwent surgery from April 2021 to May ...

Application of ultrasound measurement of inferior vena cava collapse index in evaluating pre-anesthesia blood volume in critically ill pregnant women

GAO Jiaojiao, LI Xiaohong, TAO Jing, DAI Wentao

2023, 21(7): 1125-1129. doi: 10.16766/j.cnki.issn.1674-4152.003065

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Objective To explore the clinical value of ultrasound measurement of inferior vena cava collapse index (IVC-CI) in critically ill pregnant women for evaluating their pre-anesthesia blood volume. Methods A total of 90 critically ill pregnant women who underwent elective cesarean section at the First ...

Clinical experience of intravenous removal of lead electrodes in middle-aged and elderly patients with delayed infection of cardiac implantable electronic device

WU Mengwei, HU Yidong, YANG Liu, HU Kai, SU Hao

2023, 21(7): 1130-1133. doi: 10.16766/j.cnki.issn.1674-4152.003066

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Objective To retrospectively analyze the safety and feasibility of transvenous lead extraction (TLE) in middle-aged and elderly with delayed infection of cardiac implantable electronic device (CIED). Methods A total of 60 TLE patients with delayed infection of CIED hospitalized at the First Hospital...

Clinical features, treatment and prognosis of vaginal intraepithelial neoplasia

WANG Yafei, WANG Liqun, YE Guoliu

2023, 21(7): 1134-1137. doi: 10.16766/j.cnki.issn.1674-4152.003067

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Objective To study the general clinical characteristics, treatment and prognosis of vaginal intraepithelial neoplasia (VAIN). Methods The clinical data of 168 patients with histologically confirmed VAIN admitted to the First Affiliated Hospital of Bengbu Medical College from January 2019 to February...

Clinical efficacy of sacubitril/valsartan in the treatment of hypertension with left ventricular hypertrophy research

ZHANG Tingting, GE Huijuan, ZHUANG Xiaosai, REN Lei, NING Bin

2023, 21(7): 1138-1142. doi: 10.16766/j.cnki.issn.1674-4152.003068

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Objective To explore the role of sacubitril/valsartan in reversing hypertension with left ventricular hypertrophy. Methods Ninety patients with hypertension and left ventricular hypertrophy who visited the Department of Cardiology of Fuyang People's Hospital from February to August 2021 were selecte...

Changes of peripheral blood miR-145 level and its effect on PAI-1 in patients with repeated implantation failure

DU Dan, YANG Fan, HE Ping, CHEN Hui, ZHAO Yan, WANG Jing, LIU Haipeng, PENG Shuming

2023, 21(7): 1143-1146. doi: 10.16766/j.cnki.issn.1674-4152.003069

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Objective To investigate the changes of serum miR-145 levels and their impact on plasminogen activator inhibitor 1 (PAI-1) in patients with repeated implantation failure before egg retrieval and embryo transfer. Methods A total of 71 cases of repeated implantation failure (RIF) in the Reproductive M...

Correlation between frailty and self-efficacy in patients with type 2 diabetes and its influencing factors

ZHANG Ying, ZHENG Jing, GUAN Yuxiang, XU Juan, WANG Chao

2023, 21(7): 1153-1156. doi: 10.16766/j.cnki.issn.1674-4152.003072

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Objective To investigate the current status of frailty in patients with type 2 diabetes mellitus (T2DM) and analyze the related factors of frailty, and explore the relationship between frailty and self-efficacy in patients with T2DM. Methods This study was a cross-sectional study. Patients with T2DM...

Study on the variability curve of family mode pulmonary rehabilitation compliance in patients with chronic obstructive pulmonary disease

ZHAI Wenshuang, CAI Hanjiong, QIAN Jia, GUO Liqin

2023, 21(7): 1157-1160. doi: 10.16766/j.cnki.issn.1674-4152.003073

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Objective To study the variety rule of family mode pulmonary rehabilitation compliance in patients with chronic obstructive pulmonary disease (COPD), find influencing factors, and identify intervention nodes. Methods Eighty-two COPD patients who were hospitalized in the Department of Respiratory and...

Predictive role of peripheral blood cell parameters in the cancer development of hydatidiform moles

LI Mingwei, WU Fang, CHENG Jin, ZHOU Ping

2023, 21(7): 1161-1164. doi: 10.16766/j.cnki.issn.1674-4152.003074

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Objective To investigate the clinical value of red blood cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), platelet count (PLT) and absolute neutrophil count (N) in predicting malignant transformation of hydatidiform mole prior to the initial curettage. Methods A total of 88 hydatidi...

Genotypic characteristics and clinical significance of cytomegalovirus infection in children with thrombocytopenia under 12 months old

LIU Hui, SANG Xu, WANG Lei, ZHOU Rui, DONG Huaifu

2023, 21(7): 1165-1168. doi: 10.16766/j.cnki.issn.1674-4152.003075

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Objective To collect clinical cases of cytomegalovirus (CMV) related thrombocytopenia in infants and study the relationship between glycoprotein B, H (gB, gH) genotypes and CMV related thrombocytopenia. Methods A total of 697 CMV-positive cases treated at the First Affiliated Hospital of Bengbu Medi...

The necessity for a prenatal diagnosis of isolated fetal choroid plexus cyst

SUN Yuxiu, TANG Junxiang, WANG Chaohong, WANG Yaqun, WANG Senlin, ZHU Jiansheng

2023, 21(7): 1169-1171. doi: 10.16766/j.cnki.issn.1674-4152.003076

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Objective Karyotype analysis and chromosomal microarray analysis were used to explore the necessity of prenatal diagnosis of choroid plexus cyst (CPC), to provide a basis for prenatal consultation. Methods A total of 276 pregnant women who were diagnosed as fetal choroid plexus cysts by ultrasound a...

Study on the effect of self-made traditional Chinese medicine formula combined with far infrared therapeutic instrument in the treatment of drug exudation or extravasation in children

LI Na, LI Nan, WEI Xueyan, SHI Junran, WANG Jingjun, ZHOU Xiumin, LIU Yanxia

2023, 21(7): 1172-1174. doi: 10.16766/j.cnki.issn.1674-4152.003077

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Objective To explore the clinical efficacy of self-made traditional Chinese medicine prescription combined with far infrared therapeutic instrument in the treatment of drug exudation in children and its impact on the levels of serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in p...

Study on the correlation between micronutrient intake during pregnancy and glycemic control outcomes in patients with gestational diabetes

ZHANG Changying, CHEN Xueli, FENG Yunren, SHI Liang, HE Yuan

2023, 21(7): 1175-1178. doi: 10.16766/j.cnki.issn.1674-4152.003078

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Objective To analyze the correlation between micronutrients intake during pregnancy and the effect of blood glucose control in patients with gestational diabetes (GDM), and to provide a basis for clinical supplementation of micronutrients. Methods From May 2020 to January 2023, 100 GDM patients who ...

Analysis of the demand and influencing factors of community home combined medical and health care services in the elderly based on the Anderson model

TAN Mei, ZHANG Yuting, ZHANG Yan, BAI Simin, ZHANG Min, CHEN Yu

2023, 21(7): 1179-1183. doi: 10.16766/j.cnki.issn.1674-4152.003079

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Objective To understand the current situation of the demand for community home combined medical and health care services for the elderly in Shaanxi Province and analyze its influencing factors, in order to provide a theoretical basis for the construction of a multi-level combined medical and health ...

Prevalence and associated factors of chronic orthostatic intolerance in communities

LI Guanfei, ZHANG Xunjuan, PANG Meng, LI Song

2023, 21(7): 1184-1187. doi: 10.16766/j.cnki.issn.1674-4152.003080

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Objective To investigate the prevalence and associated factors of chronic orthostatic intolerance (OI) in community-dwelling middle-aged and elderly people. Methods From January to September 2021, a random cluster sample of 546 registered residents aged ≥40 years in three community health services i...

Construction and application of health management program based on HAPA for elderly patients with sarcopenia

SHA Wenna, CHEN Meihong, NING Li, JIN Jianfen, FU Qiuyan, ZHANG Qixiu

2023, 21(7): 1188-1191. doi: 10.16766/j.cnki.issn.1674-4152.003081

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Objective To construct health management program based on health action process approach (HAPA) for elderly patients with sarcopenia, and explore its application effects through prospective and randomized studies. Methods A total of 100 participants were recruited in the Geriatric Department of Hang...

Survey on mobile phone dependency among medical students and analysis of its influencing factors

ZHANG Ziyao, LU Qiao, LIU Weihao, CHEN Zeliang, CHENG Chi, ANG Shaojia, JIANG Yuzhou, PAN Mengdie

2023, 21(7): 1192-1196. doi: 10.16766/j.cnki.issn.1674-4152.003082

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Objective To investigate the current situation of mobile phone use among medical students at universities, to explore the relationship between medical students ' sense of purpose in life, coping styles and mobile phone addiction, and to analyze the mental health problems of mobile phone addicts. Met...

CT imaging diagnosis of primary pulmonary mucinous adenocarcinoma

CHEN Wu, SONG Biao, WANG Bin, LI Yuan, SONG Qilong, WANG Zhaohua, MIN Xuhong

2023, 21(7): 1197-1201. doi: 10.16766/j.cnki.issn.1674-4152.003083

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Objective To investigate and summarize the CT imaging characteristics of primary pulmonary mucinous adenocarcinoma, diagnose the disease early through its imaging characteristics, and select appropriate treatment methods, so as to improve survival. Methods A total of 62 cases of pathologically confi...

Application value of superb microvascular imaging-based vascular index to quantitatively assess liver fibrosis

HE Yadong, SUN Yixue, PANG Qing, LI Dongdong, LI Yang

2023, 21(7): 1202-1205. doi: 10.16766/j.cnki.issn.1674-4152.003084

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Objective The Superb microvascular imaging (SMI) -based vascular index (SMI-VI) technique was applied to evaluate neovascularization in patients with hepatic fibrosis, to provide a new repeatable and quantitative assessment of the extent of liver fibrosis. Methods The SMI technique was used to measu...

Research progress on correlations between CD36 and type 2 diabetes mellitus

HUANG Qian, LIU Deliang, LI Huilin

2023, 21(7): 1206-1210. doi: 10.16766/j.cnki.issn.1674-4152.003085

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With the rapid development of the global economy, the improvement of people's living standards and the changes of their life style, diabetes has become one of the most severe noncommunicable diseases threatening the life and health of the whole of humanity, among which type 2 diabetes mellitus (T2DM...

Research progress of alternative splicing in autoimmune diseases

CHU Yiran, XU Shengqian

2023, 21(7): 1211-1214. doi: 10.16766/j.cnki.issn.1674-4152.003086

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Alternative splicing (AS) is a general mechanism for regulating gene expression, and up to 95% of human genes experience AS, meaning that this post-transcriptional regulatory mechanism is critical for almost all cellular processes. The general function of AS is to increase the diversity of mRNA expr...

Reliability and validity test and application value of hierarchical diagnosis and treatment rating scale in rehabilitation medicine in stroke patients

XUE Kaiwen, LYU Xing, WANG Yulong

2023, 21(7): 1215-1219. doi: 10.16766/j.cnki.issn.1674-4152.003087

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Objective To evaluate the reliability, validity and cut-off points of version A and B of the hierarchical diagnosis and treatment rating scale, and to determine a more applicable version. Methods The study was conducted in four rehabilitation facilities in Shenzhen in April 2022, and the scales were...

Epidemiological investigation and correlation analysis of enuresis in children and adolescents aged 5-18 years in Pudong New District of Shanghai

WANG Zhangjuan, SHEN Xiaoyu, YIN Lei, SHA Sha, ZHOU Wei, ZHAO Li, GONG Lixia

2023, 21(7): 1220-1223. doi: 10.16766/j.cnki.issn.1674-4152.003088

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Objective To investigate the prevalence and related factors of nocturnal enuresis in children and adolescents aged 5-18 years in Pudong New Area of Shanghai, and to provide evidence for clinical prevention and treatment. Methods Using a cross-sectional survey research method, a questionnaire survey ...

Exploration the optimization of the special interests training program for general practitioners based on grounded theory

MENG Jia, GUO Meng, WANG Junying, JIANG Lihong

2023, 21(7): 1224-1228. doi: 10.16766/j.cnki.issn.1674-4152.003089

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Objective To comprehensively explore the factors influencing the special interests training program for general practitioners from a grounded theory perspective, and to provide empirical support for optimizing the implementation of the special interests training program. Methods The semi-structured ...

Analysis of the application effect in teaching introduction to general practice by teaching mode through integration of Face-to-face Learning and E-learning into Five-steps

WANG Changhong, BAI Zhifeng, CHEN Liqiao, SONG Xiangquan, FU Hua, WEI Shuangping, LI Weiming

2023, 21(7): 1229-1233. doi: 10.16766/j.cnki.issn.1674-4152.003090

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Objective To explore the application effect in the teaching of Introduction to General Practice by the teaching mode of integrating face-to-face learning and e-learning into five-step (learning, speaking, doing, using and thinking). To provide references for the teaching of Introduction to General P...

The study on the structural characteristics of spatial association network of hospital knowledge collaborative innovation in Henan Province

JI Ruirui, LYU Benyan, REN Wenjie

2023, 21(7): 1234-1237. doi: 10.16766/j.cnki.issn.1674-4152.003091

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Objective To study the spatial association network of knowledge collaborative innovation of hospitals in urban agglomeration of Henan Province, and to provide decision-making reference for promoting hospital innovation collaboration, medical and health technology innovation and high-quality developm...

Norm construction of scores for patient reported outcomes of hypertension

WANG Han, TANG Shunding, DENG Li, ZHANG Wen, ZHANG Xiaoqing

2023, 21(7): 1238-1242. doi: 10.16766/j.cnki.issn.1674-4152.003092

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Objective To establish the demarcation norm of the patient-reported outcomes of hypertension, and provide evidence for clinical treatment. Methods Patients with hypertension diagnosed in 4 counties of 2 cities in Yunnan Province who were single-drug patients were randomly selected from April to June...

Expression and clinical significance of CPT2 in renal clear cell carcinoma

GAO Xingfu, GUAN Han, YAN Ruilian, LING Nengyong, LUO Wenhao, WANG Sheng

2023, 21(7): 1243-1247. doi: 10.16766/j.cnki.issn.1674-4152.003093

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Objective To investigate the differential expression of carnitine palmitoyltransferase 2 (CPT2) in renal clear cell carcinoma (ccRCC) and its correlation with clinical prognosis, in order to provide a new biological therapy target and theoretical basis for the diagnosis and treatment of ccRCC. Metho...

Effect of video based finger exercises on postoperative limb symptoms and sleep quality in patients undergoing coronary intervention therapy

ZHOU Jing, LI Miaonan, ZHAO Na, WANG Dongmei, XIE Ying, WANG Jiaoshu, CAO Jiayu

2023, 21(7): 1248-1250. doi: 10.16766/j.cnki.issn.1674-4152.003094

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Objective To explore the effect of video based finger exercises on patients after coronary intervention therapy. Methods A total of 83 patients with coronary heart disease who were hospitalized in the Department of Cardiovascular, the First Affiliated Hospital of Bengbu Medical College from June 202...

Effects of Manchester pain management model on postoperative pain and negative emotions of patients with thoracic tumor

HU Xiaoqing, YING Huajuan, REN Jiawei, RUAN Guodong

2023, 21(7): 1251-1254. doi: 10.16766/j.cnki.issn.1674-4152.003095

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Objective To analyze the influence of Manchester pain management mode on the pain degree of patients with chest tumor, and provide a basis for clinical pain management. Methods Using the convenient sampling method, 120 patients with thoracic tumor who were treated in Hospital from February 2021 to O...

Analysis of influencing factors of self-perceived burden in children with Henoch-Schoenlein purpura

NIAN Hongyan, YANG Congyan, XU Bing

2023, 21(7): 1255-1258. doi: 10.16766/j.cnki.issn.1674-4152.003096

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Objective To investigate the status of self-perceived burden in children with Henoch-Schoenlein purpura, analyze the relationship with family care, mental toughness and self-perceived burden, and explore the influencing factors of self-perceived burden. Methods A total of 133 children with Henoch-Sc...

Stanford type A aortic dissection complicated with acute ST-segment elevation myocardial infarction: A case report

WANG Baoguo, WANG Lin, LIU Yuan, LIU Jingwei, ZHANG Weihua

2023, 21(7): 1259-1262. doi: 10.16766/j.cnki.issn.1674-4152.003097

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Stanford type A aortic dissection is a severe cardiovascular emergency with the hematoma forming in the media layer due to the rupture of the ascending aortic intima. When the dissection involves the coronary ostium, it may be complicated by acute myocardial infarction, which significantly increases...

A case study of squamous cell carcinoma of the vulva in complete remission after radical radiotherapy

YANG Xiaoting, CAI Mei, LI Nan

2023, 21(7): 1263-1266. doi: 10.16766/j.cnki.issn.1674-4152.003098

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The patient is a female, 80-year old, with vulvar discomfort for 2 years, with bilateral labia majora plaques and ulcers for more than 3 months. Histopathological examination of tissue biopsies showed irregular epidermal hyperplasia with infiltration into the dermis, formation of squamous cell masse...

Efficacy of self-designed Shufeng Jiedu formula combined with calcipotriol on psoriasis and its influence on immune function

DING Rong, HUANG Qiaoling, CHEN Zhiwei, PAN Qianxiong

2023, 21(7): 1147-1149. doi: 10.16766/j.cnki.issn.1674-4152.003070

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Objective To observe the efficacy of self-designed Shufeng Jiedu formula combined with calcipotriol on psoriasis and its influence on immune function, and provide theoretical reference for clinical treatment of psoriasis. Methods A total of 60 patients with psoriasis treated in Ruian Hospital of Tra...

Efficacy of anlotinib in the third-line treatment of advanced ovarian cancer

LI Chengbiao, GU Gangshou

2023, 21(7): 1150-1152. doi: 10.16766/j.cnki.issn.1674-4152.003071

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Objective To observe the clinical efficacy and toxicity of anlotinib as a third-line treatment for advanced ovarian cancer, and to evaluate the clinical value of this treatment. Methods A total of 60 patients with advanced ovarian cancer who were treated in Wuwei People's Hospital from May 1, 2020 t...

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2023 Vol. 21, No. 7

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