中华全科医学

Strengthen the mechanism to encourage general hospitals to participate in the family doctor contract service

CHEN Siyu, MA Li

2025, 23(1): 1-4. doi: 10.16766/j.cnki.issn.1674-4152.003824

151 19

Abstract:
The advancement of high-quality contracted family doctor services is an inevitable consequence of the need to fully mobilize the strength of general practitioners in order to continuously increase the supply capacity and connotation construction of contracted services in the new era. This is also on...

Clinical practice guidelines for the diagnosis and treatment of osteoporosis secondary to ankylosing spondylitis

2025, 23(1): 5-16. doi: 10.16766/j.cnki.issn.1674-4152.003825

144 12

Abstract:
Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton, including the spine and sacroiliac joints. AS can lead to multi-system complications, with secondary osteoporosis being common. Currently, there are no relevant consensus or guidelines on diagnosis ...

Analysis of the efficacy of combined immunotherapy and radiotherapy in patients with brain metastasis from driver-gene negative non-small cell lung cancer

ZHANG Qun, ZHOU Shixiang, SHI Xueling, YU Dingyue, ZHOU Ying, YU Jiaqi, LI Duojie

2025, 23(1): 17-20. doi: 10.16766/j.cnki.issn.1674-4152.003826

129 6

Abstract:
Objective Exploring the efficacy and safety of combined immunotherapy and radiotherapy in patients with brain metastasis from driver-gene negative non-small cell lung cancer (NSCLC). Methods A total of 108 NSCLC patients with brain metastasis, admitted to the First Affiliated Hospital of Bengbu Medi...

Construction and validation for a prognostic model of pyroptosis from lung adenocarcinoma based on machine learning

CHEN Shaoming, HU Yan, HONG Xudong, ZHENG Wei, HU Xugang

2025, 23(1): 21-25. doi: 10.16766/j.cnki.issn.1674-4152.003827

83 8

Abstract:
Objective To construct a prognostic model for lung adenocarcinoma (LUAD) based on pyroptosis related genes (PRGs) and evaluate its association with immune regulation. Methods LUAD gene expression and clinicopathological data were obtained from the TCGA database, and differentially expressed PRGs wer...

Prevalence and risk factors of pulmonary nodules among the occupational population in Anshun

FENG Ying, HU Meigui, CHENG Yiju, FAN Maofei

2025, 23(1): 26-30. doi: 10.16766/j.cnki.issn.1674-4152.003828

70 4

Abstract:
Objective As the most common clinical indicator of early lung cancer, the early detection of pulmonary nodules is crucial for lung cancer prevention and treatment. Based on the screening cohort of respiratory diseases in Anshun city, this study analyzed the characteristics of pulmonary nodules in th...

Screening novel targets for combination immunotherapy of colorectal cancer based on cancer immune cycle

ZENG Wei, TANG Jubin, CHEN Xiangzhou, CHEN Wei, YANG Dan, ZHU Jinfeng

2025, 23(1): 31-35. doi: 10.16766/j.cnki.issn.1674-4152.003829

95 2

Abstract:
Objective At this stage, immune checkpoint inhibitors (ICIs) are approved for the treatment of colorectal cancer. However, about 50% of dMMR/MSI-H-type patients are primarily resistant to ICIs, and MSS/pMMR-type patients have limited response to single-agent ICIs; therefore, there is an urgent need ...

Analysis of 25-hydroxyvitamin D levels and its association with bone turnover markers and bone mineral density in Xiangshan County adults

BAO Hongdan, ZHOU Yafen, SHI Qiongyao, GUO Jingyi, ZHANG Zhenlin, GAO Chao

2025, 23(1): 36-39. doi: 10.16766/j.cnki.issn.1674-4152.003830

64 6

Abstract:
Objective To investigate the level and deficiency of 25-hydroxyvitamin D [25(OH)D] in adults living in Xiangshan County, Ningbo City, and to analyze the association between 25(OH)D levels with bone turnover markers (BTMs) and bone mineral density (BMD). Methods From August to November 2020, 3 117 vo...

Abnormal expression and clinical significance of CABYR in gastric cancer

ZHAO Hao, ZHANG Wenjing, YANG Zi, ZHANG Xiaofeng, NIU Jiaqi, SONG Xue

2025, 23(1): 40-44. doi: 10.16766/j.cnki.issn.1674-4152.003831

76 2

Abstract:
Objective To investigate the expression of calciumbinding tyrosine phosphorylation-regulated gene (CABYR) in gastric cancer tissues and its relationship with clinicopathological parameters, and to explore its relationship with the long-term prognosis of gastric patient. Methods The expression level ...

Analysis of the safety and efficacy of proximal gastrectomy of esophageal-jejunal π-type anastomosis and circular anastomosis

WANG Mingqing, SHENG Weiwei, CAO Guodong, XIA Guozhi, GENG Qilong, XIONG Maoming, HU Kongwang

2025, 23(1): 45-49. doi: 10.16766/j.cnki.issn.1674-4152.003832

62 3

Abstract:
Objective Compare the perioperative and postoperative outcomes of two different digestive reconstructions: improved endoscopic esophago-jejunal π-anastomosis and open circular anastomosis in proximal gastrectomy. We investigated the safety and effectiveness of improved π-anastomosis combined with du...

Causal relationship between fasting plasma glucose and coronary heart disease based on two-sample mendelian randomization

LI Yan, ZHANG Yuxia, SHAN Haiyan

2025, 23(1): 50-54. doi: 10.16766/j.cnki.issn.1674-4152.003833

96 5

Abstract:
Objective Using two-sample mendelian randomization analysis to investigate the causal relationship between fasting plasma glucose and coronary heart disease, and to provide a basis for clinical prevention and treatment of coronary heart disease. Methods The causal relationship between fasting plasma...

Relationship of perineural invasion with clinicopathological features and prognosis in breast cancer patients

PENG Puchao, CHEN Lijie, XUAN Haojun, YAO Min, DENG Zaixing, ZHANG Xin, DING Xiufang

2025, 23(1): 55-58. doi: 10.16766/j.cnki.issn.1674-4152.003834

95 1

Abstract:
Objective The prognostic and survival significance of perineural invasion in breast cancer was not clear, the relationship of perineural invasion with clinicopathological characteristics and the effect on the prognosis of breast cancer were analyzed, so as to provide a basis for accurate evaluation ...

A study on clinical characteristics and prognostic factors of HFpEF patients using ARNI based on latent class analysis

HE Wenchao, ZHU Mucheng, SU Quanbin, ZHANG Qi, ZENG Wenbao, YAO Siqi, ZHANG Zhengyi

2025, 23(1): 59-64. doi: 10.16766/j.cnki.issn.1674-4152.003835

65 5

Abstract:
Objective This study applied the potential category analysis method with the aim of observing the efficacy of angiotensin receptor enkephalinase inhibitors in patients with HFpEF and analyzing the factors affecting the prognosis of the patients and the related different characteristic subtypes. Meth...

Analysis of factors influencing high risk of type 2 diabetes mellitus combined with malnutrition and sarcopenia in elderly patients

XIE Minghui, LIANG Bing, JIN Guoxi, WEI Nana, LIU Yurun

2025, 23(1): 65-68. doi: 10.16766/j.cnki.issn.1674-4152.003836

72 8

Abstract:
Objective This study aims to investigate the high risk of sarcopenia in elderly patients with type 2 diabetes mellitus complicated with malnutrition, and analyze underlying causes of sarcopenia. Methods A total of 212 elderly patients with type 2 diabetes mellitus and malnutrition (aged≥60 years old...

Curative effect observation of donepezil combined with calcitriol in the treatment of mild cognitive impairment

SHEN Jiaying, FAN Jiajia, ZHANG Chen, WANG Xiaoyan, ZHU Mengna, REN Jingjing

2025, 23(1): 69-72. doi: 10.16766/j.cnki.issn.1674-4152.003837

89 5

Abstract:
Objective The present study aims to compare and analyze the clinical efficacy of donepezil monotherapy versus the combination therapy of donepezil and calcitriol in treating mild cognitive impairment (MCI), with the intention of providing a scientific basis and guidance for therapeutic regimens for ...

Influence of disease perception and treatment confidence on treatment compliance of adolescents with non-suicidal self-injury tendency

SHEN Qinwei, LUO Ping, ZHENG Jifeng

2025, 23(1): 73-76. doi: 10.16766/j.cnki.issn.1674-4152.003838

70 1

Abstract:
Objective To investigate the treatment compliance of adolescent patients with non-suicidal self-injury tendency and its related influencing factors, and analyze the effects of disease perception and treatment confidence on treatment compliance. Methods A total of 113 adolescent patients with non-sui...

Analysis of the influence of remazolam on delirium risk in elderly surgical patients

HUANG Changjun, XIE Xiuxiu, GUO Shaohui, SHI Siren

2025, 23(1): 77-80. doi: 10.16766/j.cnki.issn.1674-4152.003839

89 2

Abstract:
Objective Elderly patients undergoing hip replacement surgery are at high risk of postoperative delirium. The rational selection of anesthetic drugs is crucial to reducing this risk. A new type of ultra-short-acting benzodiazepine intravenous sedative, remazolam, offers advantages such as quick onse...

Investigation and analysis of problems related to clinical application of hypoglycemic drugs in diabetic patients

LI Yang, HU Xiaolei, ZHU Yuehao

2025, 23(1): 81-84. doi: 10.16766/j.cnki.issn.1674-4152.003840

115 4

Abstract:
Objective Based on the Spanish classification (GRANADA-Ⅱ), drug-related problems (DRPs) in the clinical application of hypoglycemic drugs in inpatients with diabetes is investigated and analyzed. Methods A retrospective study was conducted to select 400 hospitalized patients with diabetes admitted t...

Effects of hand, foot, and mouth disease on oral microbiota in children

JIANG Yazhou, ZHU Suyue, QIAO Jibing, SHEN Nan, WU Rang, LIU Feng

2025, 23(1): 85-88. doi: 10.16766/j.cnki.issn.1674-4152.003841

66 2

Abstract:
Objective To detect and analyze the changes in oral microbiota of children with hand, foot, and mouth disease (HFMD) by high-throughput sequencing technology. Methods A total of 86 children diagnosed with HFMD in Suqian Hospital Affiliated to Xuzhou Medical University from April 2021 to September 20...

A study on the temporal and spatial differences in refractive progression among children aged 3-16 in Shanghai

SHAO Jie, HUANG Jiaoling, CHEN Jinzhi, GAO Zitian, HUANG Qian, ZHANG Yi, WANG Yulin

2025, 23(1): 89-93. doi: 10.16766/j.cnki.issn.1674-4152.003842

80 2

Abstract:
Objective Explore the characteristics and influencing factors of refractive development in children of different ages and refractive states in urban and suburban areas, and provide the scientific basis for precise prevention and control of myopia. Methods Using cluster sampling, a total of 10 652 ch...

Dynamic changes in metabolic indexes following organophosphorus poisoning and their correlation with prognosis in hospital

XU Xunhong, XU Maohua, LI Xiaohong

2025, 23(1): 94-97. doi: 10.16766/j.cnki.issn.1674-4152.003843

97 3

Abstract:
Objective Organophosphorus poisoning has an acute onset and progresses rapidly. Without timely treatment, it may lead to coma or even death. Metabolic indexes change dynamically following acute organophosphorus poisoning, which have the potential value to predict the prognosis of organophosphorus po...

Application of Skinner' s procedural teaching theory in health education for high-risk patients with diabetic foot

SU Qiaodan, ZHUGE Fuyuan, WANG Jun, TU Xin

2025, 23(1): 98-102. doi: 10.16766/j.cnki.issn.1674-4152.003844

64 3

Abstract:
Objective Health education plays an important role in preventing diabetic foot. This study discusses the application of Skinner' s procedural teaching theory in the health education of high-risk patients with diabetic foot, aiming to reduce the risk of diabetic foot occurrence and improve the qualit...

The effect of problem-solving therapy on depressive symptoms and cognitive flexibility in patients with primary moderate to severe depression

FAN Yadan, CHEN Jing, YU Xiaoding, LUO Ping

2025, 23(1): 103-106. doi: 10.16766/j.cnki.issn.1674-4152.003845

90 4

Abstract:
Objective To analyze the application effect of problem-solving therapy intervention on the basis of routine nursing in patients with first-episode depression, and its impact on patients' depressive symptoms and cognitive flexibility. Methods A total of 126 patients with first-episode moderate to sev...

Study on the pelvic floor ultrasound for evaluating the therapeutic effect level of mixed urinary incontinence in women

LIU Shanshan, FANG Yue, ZHOU Yibo

2025, 23(1): 107-110. doi: 10.16766/j.cnki.issn.1674-4152.003846

91 1

Abstract:
Objective To improve the clinical treatment level of mixed urinary incontinence (MUI) and enrich the monitoring pathways of MUI condition, the feasibility of using pelvic floor ultrasound for the diagnosis and efficacy monitoring of MUI is explored. Methods A total of 170 female patients with MUI ad...

Correlation between the dynamic analysis of D-dimer levels and post-treatment ultrasonic characteristics in patients with venous thrombosis of lower limbs

JIANG Junjie, SHENG Chenwei

2025, 23(1): 111-114. doi: 10.16766/j.cnki.issn.1674-4152.003847

67 1

Abstract:
Objective To detect the level of D-dimer in patients with venous thrombosis of lower limbs and analyze the relationship between the ultrasonic characteristics of patients after treatment and the dynamic changes in D-dimer level. Methods One hundred and twenty-seven patients with deep venous thrombos...

A systematic evaluation of theories and research on self-health management interventions for community populations

LI Wanyu, GU Chao, ZHANG Min, JIN Hua, YU Dehua

2025, 23(1): 115-121. doi: 10.16766/j.cnki.issn.1674-4152.003848

117 9

Abstract:
Based on the current increase in the number of patients with chronic diseases and the growing demand for health management, the importance of self-health management is becoming more and more prominent, and the implementation of effective self-management by community residents can help to improve the...

Research progress of exosome-deriveds non-coding RNA in osteosarcoma metastasis

HU Xuemei, PAN Baolong, BAI Yingying, YANG Yang

2025, 23(1): 122-126. doi: 10.16766/j.cnki.issn.1674-4152.003849

69 4

Abstract:
Osteosarcoma (OS) is a malignant bone tumor primarily affects in children and adolescents, characterized by rapid progression, high malignancy, and easy metastasis. Metastasis of osteosarcoma often occurs in the early stage of the disease, with the lungs being the primary site of spread, contributin...

Study on the clinical effect of manual lymphatic drainage combined with intramuscular sticking on postoperative rehabilitation of breast cancer patients

HE Ximei, CAO Yachen, ZHOU Xiang, YE Zhiqiang

2025, 23(1): 127-130. doi: 10.16766/j.cnki.issn.1674-4152.003850

93 3

Abstract:
Objective In order to improve the postoperative rehabilitation level of breast cancer patients, to explore the clinical effect of manual lymphatic drainage combined with intramuscular plaster in such patients. Methods A total of 130 patients who underwent breast cancer surgery in the First Affiliate...

The treatment of third lumbar transverse process syndrome by ultrasound visualization injection and acupotomy based on holistic mechanics

XU Qianlan, WANG Huayan, ZHAN Jingjing, WU Dan, DU Fenfei

2025, 23(1): 131-134. doi: 10.16766/j.cnki.issn.1674-4152.003851

69 2

Abstract:
Objective To observe the effect and safety of acupotomy release under ultrasound visualization injection based on global mechanics in patients with third lumbar transverse process syndrome. Methods A total of 90 patients with third lumbar transverse process syndrome admitted to Dongyang People' s Ho...

A survey on the research thinking and writing skills of clinical medicine postgraduate students

ZHONG Jianhong, HUO Rongrui, CHEN Kang, YOU Xuemei, MA Liang, NING Ruiling

2025, 23(1): 135-139. doi: 10.16766/j.cnki.issn.1674-4152.003852

80 5

Abstract:
Objective To investigate the research thinking, paper writing and publication status, writing challenges, and guidance expectations of clinical medicine postgraduate students, with the goal of optimizing the teaching model for postgraduate research courses. Methods A questionnaire survey method was ...

Effectiveness of an intelligent warning system in bundle therapy for septic shock patients

CHEN Xiaolei, WU Huihui, ZHANG Qixia, MU Jingjing, WU Xiaoxiao

2025, 23(1): 140-142. doi: 10.16766/j.cnki.issn.1674-4152.003853

86 2

Abstract:
Objective To explore the effect of an intelligent warning system on the management of Intensive Care Unit (ICU) patients with septic shock and to improve the treatment effect. Methods A total of 129 patients with septic shock in the ICU of the First Affiliated Hospital of Wenzhou Medical University ...

Meta-analysis of preoperative oral carbohydrate effects in patients with thyroidectomy

LIU Jie, HAN Peng, SUI Fang, YAN Jinfeng, ZHANG Xiping, HOU Huan, BI Ying

2025, 23(1): 143-147. doi: 10.16766/j.cnki.issn.1674-4152.003854

60 2

Abstract:
Objective To evaluate the efficacy and safety of preoperative oral carbohydrate in patients with thyroidectomy during the perioperative period by meta-analysis, and to guide the clinical implementation. Methods CNKI, VIP, Wanfang, PubMed, Embase, Web of Science, Wiley Online Library, and other Chine...

Difference of fall risk and risk perception in elderly patients with hip fracture after operation in rehabilitation period

YANG Chang, ZHOU Minjie, LING Lejie, LUO Guogang

2025, 23(1): 148-152. doi: 10.16766/j.cnki.issn.1674-4152.003855

68 2

Abstract:
Objective To explore the present situation of fall risk of elderly patients with hip fracture in rehabilitation period after operation and the difference of risk perception level among patients with different fall risk levels. Methods A total of 356 elderly patients with hip fracture in rehabilitati...

Integrating HFEMA and the CATCH model to develop a fall safety management system for elderly patients

JIAO Jianhui, HU Lanying, ZHANG Yu, LI Zhiping, SHAN Qing, ZHANG Xiao, YANG Yan, YUAN Yuan

2025, 23(1): 153-156. doi: 10.16766/j.cnki.issn.1674-4152.003856

88 3

Abstract:
Objective To explore the effectiveness of combing the healthcare failure mode and effect analysis (HFEMA) with the CATCH fall management model in constructing a fall management system for elderly hospitalized patients. Methods A total of 36 888 elderly patients hospitalized at our hospital from Janu...

Effects of 6S+X management on hospital services in public hospitals under the mode of one hospital and two districts

LIU Yuan, YANG Xuezhi, LIU Xiaoju, SU Xun, YUAN Ting

2025, 23(1): 157-161. doi: 10.16766/j.cnki.issn.1674-4152.003857

77 5

Abstract:
Objective To explore the practice effects of 6S+X management on deepening high-quality hospital services in public hospitals under the mode of one hospital and two districts so as to improve the quality of medical services. Methods A total of 30 nursing staff from Chengdu 363th Hospital Affiliated t...

The impact of risk grading nursing combined with closed-loop management on clinical symptoms, functional recovery, and psychological status of children with bacterial pneumonia

LIN Xiaomin, CAI Yuanyuan, QIAN Jinji, LIN Xiaoqing

2025, 23(1): 162-166. doi: 10.16766/j.cnki.issn.1674-4152.003858

78 4

Abstract:
Objective The present study will discuss the effect of combining risk grading nursing with closed-loop management in children with bacterial pneumonia. The impact on the clinical symptoms, functional recovery, and psychological state of the children will be observed. The study will provide a new the...

Effects of Habilitation nursing model on glycemic control and cognitive function in patients with diabetic encephalopathy

WANG Xue, DONG Binglun, LU Yang, LIU Yu, ZHAO Xin

2025, 23(1): 167-171. doi: 10.16766/j.cnki.issn.1674-4152.003859

65 3

Abstract:
Objective To investigate the efficacy of Habilitation nursing model in patients with diabetic encephalopathy (DE) and its influence on glycemic control and cognitive function. Methods From January 2021 to June 2023, a total of 398 patients with DE were selected from Qinhuangdao Hospital of Tradition...

Perioperative anesthesia management for scoliosis correction in a patient with severe pulmonary insufficiency: a case report

ZHU Xurui, HAO Jing, ZHANG Wei, DONG Yuanyuan, GU Xiaoping

2025, 23(1): 172-174. doi: 10.16766/j.cnki.issn.1674-4152.003860

80 10

Abstract:
Patients with combined thoracic deformities due to spinal scoliosis often suffer severe lung function impairment, posing a high risk for anesthesia during surgery. Shortly after spinal orthopaedic surgery, their lung function typically deteriorates further. Therefore, implementing appropriate periop...

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2025 Vol. 23, No. 1

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