Effect of inflammatory media on bone marrow mesenchymal stem cell transplantation in leukemia patients

Objective To investigate the effect of proinflammatory cytokines on the outcome and prognosis of bone marrow mesenchyma stem cells (BMSCs) transplantation in leukemia patients. Methods A total of 82 patients with leukemia who underwent treatment from our hospital from 3 November, 2015 to 3 May, 2017 were randomized to A (conventional supportive therapy) according to the random number table method. IL-1, IL-6, IL-4 and IL-12 were detected by ELISA before and after treatment, and the levels of IL-1, IL-1, IL-6, IL-6 and IL-12 were detected by ELISA And the changes of bone marrow hyperplasia before and after treatment in group B patients. Results The levels of IL-1 and TNF-α in the serum of the two groups were significantly lower than those in the control group (P<0.001), and the difference was statistically significant (t=13.652, P<0.001). IL-1, TNF-α, IL-6, IL-4 and IL-12 were significantly decreased in the B group after treatment, and the expression of IL-1 was significantly lower than that of IL-6 (t=12.247, P<0.001). The percentage of active myeloproliferation in group B was significantly higher than that before treatment (before treatment vs. before treatment:43.9% vs. 2.4%), and the difference was significant (χ²=6.276, P=0.022); the percentage of myeloproliferation was significantly reduced after treatment (before treatment vs. 19.5% vs. 43.9%), the difference was statistically significant (χ²=5.632, P=0.032). Conclusion Bone marrow mesenchymal stem cell transplantation can effectively reduce the inflammatory response, enhance myeloproliferative activity, improve the hematopoietic environment, and can be used as an adjunctive treatment for leukemia.