Interaction of household passive smoking with pickiness on hyperactivity behavior among preschool children

Objective To explore the interaction between household passive smoking and pickiness on hyperactivity behavior in preschool children. Methods A total of 15 291 parents of preschool children from 91 kindergartens were investigated by self-designed questionnaire from May, 2014 to June, 2015. A "Conners abbreviated symptom questionnaire" was used to rate hyperactivity behavior. The multivariate logistic regression and the relative excess risk due to interaction (RERI) were performed to assess the interaction of household passive smoking with pickiness on hyperactivity behavior. Results In our study, the detection rate of hyperactivity behavior was 8.6%. The household passive smoking and pickiness were significantly associated with hyperactivity behavior[OR=1.24(1.10-1.39), P<0.001; OR=2.11(1.88-2.37), P<0.001]. The results of stratified analysis showed that household passive smoking was related with hyperactivity behavior in the children without pickiness[OR=1.45(1.24-1.69), P<0.001]; but whether or not with household passive smoking, the pickiness was associated with hyperactivity behavior[OR=2.60(2.19-3.10), P<0.001; OR=1.79(1.53-2.09), P<0.001]. The multiplicative interaction of household passive smoking and pickiness on hyperactivity behavior was statistically significant[OR=0.69(0.54-0.87), P<0.01], but the additive interaction was not (RERI=0.60, 95%CI=-0.14-1.34). Conclusion The household passive smoking and pickiness were significantly associated with hyperactivity behavior and had a multiplicative interaction on hyperactivity behavior.