Effect of Shenmai injection with hemoperfusion in treatment of myocardial depression in septic shock

LU Di; YU Guo-feng; LÜ Tie; YING Li-jun

doi:10.16766/j.cnki.issn.1674-4152.000255

Volume 16 Issue 6

Jul. 2022

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Article Navigation > Chinese Journal of General Practice > 2018 > 16(6): 929-931,973

LU Di, YU Guo-feng, LÜ Tie, YING Li-jun. Effect of Shenmai injection with hemoperfusion in treatment of myocardial depression in septic shock[J]. Chinese Journal of General Practice, 2018, 16(6): 929-931,973. doi: 10.16766/j.cnki.issn.1674-4152.000255

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LU Di, YU Guo-feng, LÜ Tie, YING Li-jun. Effect of Shenmai injection with hemoperfusion in treatment of myocardial depression in septic shock[J]. Chinese Journal of General Practice, 2018, 16(6): 929-931,973. doi: 10.16766/j.cnki.issn.1674-4152.000255

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Effect of Shenmai injection with hemoperfusion in treatment of myocardial depression in septic shock

doi: 10.16766/j.cnki.issn.1674-4152.000255

Department of Critical Care Medicine, Shaoxing People' Hospital(Shaoxing Hospital of Zhejiang University), Shaoxing, Zhejiang 312000, China

Received Date: 2017-01-05
Available Online: 2022-07-29

Abstract

Abstract

Objective To investigate the effect of Shenmai injection with hemoperfusion on myocardial depressant factor(MDF) and cardiac function in septic shock. Methods In this study, 60 patients with septic shock in our Department were randomly divided into 3 groups with 20 cases in each group:the control group, the Shenmai injection group and the Shenmai injection with hemoperfusion group. All the patients received regular therapy. The patients in the Shenmai injection group were treated with Shenmai injection on the basis of the control group. The patients in the Shenmai injection with hemoperfusion group were treated with hemoperfusion(HA330) on the basis of the Shenmai injection group. The levels of APACHEⅡ score, cardiac index(CI), brain natriuretic peptide(BNP), high mobility group protein B1(HMGB-1), leukotriene(LT) and endothelin1(ET-1) before treatment and after seven days of treatment were observed. Results APACHEⅡ score, CI, BNP, HMGB-1, LT and ET-1 among the three groups were not significantly different from each other before the treatment(P>0.05). Compared with those before the treatment, APACHEⅡ score, BNP, HMGB-1, LT and ET-1 in all the three groups decreased after the treatment, CI increased after the treatment, and it was statistically significant(P<0.05). Compared with the control group and the Shenmai injection group, APACHE Ⅱ score, BNP, HMGB-1, LT and ET-1 in the Shenmai injection group were decreased after treatment, and CI was increased, and it was statistically significant(P<0.05). Compared with the Shenmai injection group and the Shenmai injection with hemoperfusion group, APACHE Ⅱ score, BNP, HMGB-1, LT and ET-1 in the Shenmai injection with hemoperfusion group were decreased after the treatment, and CI was increased, and it was statistically significant(P<0.05). Conclusion Shenmai injection with hemoperfusion can reduce the level of myocardial depressant factors, improve the ability of cardiac function and the survival rate of patients in septic shock.
- Septic Shock,
- Myocardial depressant factor,
- Shenmai injection,
- Hemoperfusion

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Effect of Shenmai injection with hemoperfusion in treatment of myocardial depression in septic shock

doi: 10.16766/j.cnki.issn.1674-4152.000255

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Effect of Shenmai injection with hemoperfusion in treatment of myocardial depression in septic shock

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