Study on the correlation between spontaneous abortion and thyroid autoantibody

Objective To investigate the correlation between spontaneous abortion and thyroid autoantibody. Methods Seventy cases of primary abortion were selected as primary abortion group, seventy cases of recurrent miscarriage were selected as recurrent miscarriage group treated in department of Obstetrics and Gynecology of Central Hospital of Huzhou, and seventy cases of healthy subjects were selected as control group from January, 2012 to December, 2016. The serum TSH, FT3, FT4, TPO-Ab, TG-Ab levels were determined. Results The positive rate of TA, TPO-Ab and TG-Ab in patients of recurrent spontaneous abortion group were higher than those in control group (P<0.05). There were no significant difference in the positive rate of TA, TPO-Ab and TG-Ab between recurrent spontaneous abortion group and the primary abortion group (P>0.05). The positive rate of TG-Ab in primary abortion group was higher than that in control group (P<0.05); the positive rate of TA and TPO-Ab showed no significant difference compared with the control group (P>0.05). The lg (TPO-Ab) in the recurrent abortion group was higher than that in the control group (P<0.05). There was no significant difference in the lg (TPO-Ab) between recurrent abortion group and primary abortion group (P>0.05). There was no significant difference in the lg (TPO-Ab) between the primary abortion group and the control group (P>0.05). There was no significant difference in lg (TG-Ab) among three groups (P>0.05). In the recurrent abortion patients, there was no significant difference in TA, TPO-Ab and TG-Ab positive rate between secondary abortion group and secondary abortion group (P>0.05); there was no significant difference in TA, TPO-Ab and TG-Ab positive rate between early abortion group and advanced abortion group (P>0.05). There was no significant difference in TA, TPO-Ab and TG-Ab positive rates between primary abortion group and secondary abortion group (P>0.05). Conclusion The positive rate and levels of serum TA, TPO-Ab and TG-Ab in patients with recurrent spontaneous abortion increase. Thyroid autoantibody is related to recurrence abortion.