Objective To investigate the effect of Sevoflurane inhalation in different time history on liver ischemia-reperfusion injury in patients with partial liver resection.
Methods Ninety cases of partial hepatectomy in our hospital from January, 2016 to December, 2017 were divided into Sevoflurane pre-treatment group, Sevoflurane after-treatment group and Sevoflurane whole course inhalation group, with 30 cases in each group. Blood samples were taken at preoperative (T0), end (T1), postoperative 24 h (T2), postoperative 3 D (T3), and postoperative 5 D (T4) and postoperative 8 D (T5). Serum SOD, MDA, IL-6, IL-10 and TNF-alpha were detected, and the number of interruption, blocking time, bleeding volume and postoperative hospitalization time were recorded.
Results ALT, AST, IL-6, TNF-alpha, IL-10 and SOD levels of pre-treatment group at different time points of T2, T3, T4 and T5 were higher than those of after-treatment group and while course inhalation group (
P<0.05); ALT, AST, IL-6 and TNF-alpha levels of after-treatment group at different time points of T2, T3, T4 and T5 were lower than those of while course inhalation group (
P<0.05); IL-10 and SOD levels of while course inhalation group at different time points of T2, T3, T4 and T5 were lower than those of after-treatment group (
P<0.05). MDA levels of pre-treatment group at different time points of T2, T3, T4 and T5 were lower than those of after-treatment group and while course inhalation group (
P<0.05); MDA levels of while course inhalation group at different time points of T2, T3, T4 and T5 were lower than those of after-treatment group (
P<0.05).
Conclusion The Sevoflurane pre-treatment can reduce hepatic ischemia reperfusion injury in patients with liver resection, probably through the IL-6 and TNF- alpha activation and release to inhibit the production of free radicals and lipid peroxidation, activate and release IL-10, and reduce the liver organ and tissue damage.
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