Clinical observation on 38 cases of postmenopausal osteoporosis treated with Jinggu Bugu granule

Objective Previous experimental studies have confirmed the therapeutic effect of Jinggu Bugu granule on dexamethasone-induced osteoporosis in rats. The study aims to verify the clinical value of the drug, and observe the clinical effect of Jinggu Bugu granule on postmenopausal osteoporosis. Methods A total of 80 patients with postmenopausal osteoporosis were collected from May, 2016 to April, 2017 in the Department of traditional Chinese Medicine of the second affiliated Hospital of Bengbu Medical College. With the informed consent of the patients,they were randomly divided into control group (40 patients in basic treatment group) and observation group (40 patients in Jinggu Bugu granule group). There was no statistical difference in the age and course of the two groups. Both groups were given 0.50 μg/d of oscitictriol in two doses. The observation group was treated with Jinggu Bugu granule once a day for 6 months. Bone pain score was observed by visual method, bone mineral density was measured by BMD and estradiol was measured by chemiluminescence. The changes in the values of the two groups were recorded and the traditional Chinese medicine score was recorded to judge the curative effect. We used SPSS 23.0 software to carry on statistics. Results One case was lost in the control group and 2 cases in the observation group. In both groups, the bone pain score decreased and the bone mineral density increased significantly. The bone pain score and bone mineral density in the observation group were significantly better than those in the control group (P<0.001). The estradiol in the observation group was significantly higher than that before the treatment (P<0.001), but the improvement of estradiol was not obvious in the control group. In improving the curative effect of TCM syndromes, the total effective rate of Jinggu Bugu granule group was 94.7% and that of the basic treatment group was 74.4%. The difference between the two groups was statistically significant (P<0.05). Conclusion Jinggu Bugu granule has good therapeutic effect on postmenopausal osteoporosis of liver and kidney yin deficiency type.