Objective To investigate the effect of Shenqijianwei Granule on chronic atrophic gastritis of motilin and gastrin and immune function.
Methods Sixty-eight patients with chronic atrophic gastritis were divided into observation group and control group, each group of 34 cases. The control group was given conventional western medicine symptomatic treatment. The observation group in the control group based on the given Shenqijianwei granules. Comparison of the two groups before and after treatment of TCM symptom score. Changes of motilin and gastrin and T lymphocytes in the two groups before and after treatment were detected.
Results The curative effect of the observation group was significantly better than that of the control group.The difference was statistically significant (
Z=2.421,
P<0.05). Two groups after the treatment of epigastric pain, epigastric fullness distension, lassitude,anorexia, total score decreased significantly (
P<0.05). After treatment,the observation group of epigastric pain, epigastric fullness distension, lassitude, anorexia, the total score was significantly lower than the control group. The difference was statistically significant (
P<0.05). After treatment, CD4 and CD4/CD8 in the observation group were significantly increased, CD8 was significantly lower (
P<0.05). After treatment, the CD4 and CD4/CD8 in the observation group were significantly higher than those in the control group, CD8 was significantly lower than that in the control group. The difference was statistically significant (
P<0.05). The two groups after treatment of motilin and gastrin increased significantly (
P<0.05). After treatment, the observation group of motilin and gastrin was significantly higher than the control group. The difference was statistically significant (
P<0.05).
Conclusion Shenqijianwei granule can improve the patients of chronic atrophic gastritis of motilin and gastrin levels, improve immune function.
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