Effect of application of preoperative drug intervention on rapid recovery and serum inflammatory factor of total laparoscopic hysterectomy patients

Objective To investigate the effect of application of dezocine combined with glucocorticoid on rapid recovery and serum inflammatory factor of total laparoscopic hysterectomy patients. Methods From July 2016 to July 2017 in The first affiliated hospital of Xi' an medical university (School of General Medicine), 50 total laparoscopic hysterectomy patients were involved and randomly divided into experimental group and control group (n=25). Patients in the experimental group were given taking orally with dezocine and glucocorticoid at 2 h before surgery. Patients in the control group were given taking orally with placebo at the same time. After surgery 1, 6, 12 and 24 h to record visual analogue scale of the two groups; To record the first use time of PCIA and the 24 h cumulative usage amount of PCIA drugs of each groups.To record the first time to get out of bed, gut exhaust time, hospitalization time and the incidence of nausea and vomiting of each group. The venous blood when entering the operation room, 2, 4 and 12 h after operation was extracted. The inflammatory factors (IL-6 and TNF-α) in serum were detected by ELISA. Results Compared with the control group, the VAS after surgery 1, 6 h of experimental group were lower than the control group, and the differences were statistically significant (P < 0.05). The first use time of PCIA and the 24 h cumulative usage amount of PCIA drugs of the experimental group were lower (P < 0.05). The first time to get out of bed, gut exhaust time, hospitalization time and the incidence of nausea and vomiting of the experimental group were lower (P < 0.05). The inflammatory factors (IL-6 and TNF-α) in serum of experimental group were lower than the control group (P < 0.05), and all the differences were statistically significant. Conclusion Application of dezocine combined with glucocorticoid could could reduce surgical stress and inflammatory factors, as well as the incidence of adverse reactions after surgery and promote rapid recovery of total laparoscopic hysterectomy patients.