The level change of FIB, HbA1c in acute cerebral infarction aged patients with different cognitive functions and their correlation with cognitive function

Objective To explore the level change of fibrinogen (FIB), glycosylated hemoglobin (Hb A1c) in acute cerebral infarction aged patients with different cognitive functions and their correlation with cognitive function. Methods A total of 237 acute cerebral infarction aged patients in our hospital were selected from March 2017 to June 2017. There were 114 cases in normal cognition group and 123 cases in cognitive dysfunction group according to the Montreal cognitive assessment scale (MoCA) score. The level of FIB and Hb A1c and the cognitive situation were compared between the two groups, and the relationship between FIB, Hb A1c and cognition were analyzed. Results The level of FIB and Hb A1c in the cognitive impairment group was significantly higher than those in the normal group (P < 0.05). The naming, language, attention and calculation, abstract thinking, visual-spatial and executive ability, delayed recall, and directional score in normal group was (2.75 ±0.21) points, (2.61 ±0.52) points, (5.63 ±0.29) points, (1.68 ±0.31) points, (4.17 ±0.76) points, (4.52 ±0.36) points, (5.28 ±0.54) points, respectively, the naming, language, attention and calculation, abstract thinking, visual-spatial and executive ability, delayed recall, and directional score in cognitive dysfunction group was (2.26 ±0.31) points, (1.57 ±0.48) points, (3.04 ±0.38) points, (1.19 ±0.36) points, (3.28 ±0.37) points, (2.38 ±0.31) points, (5.03 ±0.46) points, respectively, the naming, language, attention and calculation force, abstract thinking, visual space and executive ability, delayed recall and directional cognition of the cognitive dysfunction group were significantly lower than the normal group (all P < 0.05). FIB and Hb A1c were negatively correlated with naming, language, attention and computational power, visual space and executive ability, delayed recall, and total score of MoCA (all P < 0.05), but there is no correlation with abstract thinking and orientation (all P >0.05). Conclusion The level of FIB and Hb A1c can reflect the cognitive function of acute cerebral infarction aged patients, and they can be used as a basis for evaluating the progression of senile acute cerebral infarction.