Clinical observation on treatment of active ulcerative colitis with Chinese herbal decoction for oral taking and enema

Objective To observe the patients’ clinical symptoms and histopathological changes of Chinese herbal decoction for oral taking and enema in the treatment of active ulcerative colitis(UC), and evaluate the clinical efficacy and safety. Methods The 68 cases of UC were selected from January 2014 to June 2016 in the first affiliated hospital of Heilongjiang university of TCM department of Gastroenterology. The 68 patients with active ulcerative colitis were randomly divided into control group and treatment group with 34 cases in each group. Two groups of patients were given the necessary routine medical treatment. On these, the treatment group was treated with Chinese herbal decoction for oral taking and enema. Oral Chinese medicine were given 1 dose daily, 2 times/day, half an hour after breakfast and dinner. Enema Chinese medicine were given every night 1 dose daily. The control group was given Mesalazin Enteric-coated tablets orally, 1 g/times, 4 times/day. The two groups were treated for 1 months.After treatment, we observed the improvement of three main symptoms and colonic mucosal scores of two groups. We compared the clinical effect and observed the adverse reactions. We used statistics software SPSS 19.0 for the research of statistical data. Results After treatment, the total clinical efficiency of the treatment group was 85.29%, significantly better than 61.77% in the control group, and the difference between the two groups was statistically significant (P<0.05). After treatment, the symptoms of abdominal pain, diarrhea, pus and blood stool and mucous abscess and the internal mirror score of the colonic mucosa was significantly lower than before of two groups (all P<0.05). The improvement rate of the treatment group was significantly better than the control group after treatment (all P<0.05). Conclusion It was effective in the treatment of active ulcerative colitis with Chinese herbal decoction for oral taking and enema. It can obviously improve the main symptoms like abdominal pain, diarrhea, pus and blood stool. After that, it can repair mucosal injury and promote ulcer healing, and no obvious adverse reactions.