A study on predicting indicators for complicating pregnancy in the pregnancy women with early-onset pre-eclampsia

Objective To investigate the significances of Serum cystatin C(CYS-C), Uric Acid (UA), Creatinine (CREA) and Urea Nitrogen (BUN) and the change and correlation of the numerical for complicating pregnancy with early-onset preeclampsia. Methods Total of 64 cases of mild early-onset with preeclampsia (mild group), 55 cases of severe early-onset with preeclampsia (severe group) and 55 cases of healthy pregnant women randomly selected in the same period (28-34 weeks, normal group) admitted in the Zhangqiu District People's Hospital Affiliated to Jining Medical University from January 2015 to December 2016 was enrolled for the study. Results There was no statistical significant difference in age and gestational age (P>0.05). Serum Cystatin C(CYS-C), Uric Acid (UA), Creatinine (CREA) and Urea Nitrogen (BUN) in case group were significantly higher than the control group, differences were all statistical significant (P<0.01). ROC curve indicated that the best critical value of predictors in Early- onset Pre- eclampsia for complicating pregnancy were Serum CYS-C≥1.29 mg/L, UA≥420.00 μmol/L, CREA≥59.10 μmol/L, BUN≥5.94 mmol/L; their sensitivity were 90.1%, 73.4%, 68.3% and 42.3%, respectively; specificity were 99.8%, 99.8%, 88.2%, and 77.8%, respectively; Youden index maximum were 89.9%, 73.2%, 56.5%, and 20.1%, respectively; OR value were 16.50, 1.05, 1.25 and 18.67, respectivel; r value were 0.841, 0.741, 0.751, 0.413, 0.118, 0.345 and 0.112, respectively (all P<0.01). Conclusion Serum CYS-C, UA, CREA and BUN may reflect the progression of the disorder of severity in Early-onset Pre-eclampsia. Serum CYS-C, UA, CREA have best diagnostic efficiency. Serum BUN has poor diagnostic efficiency. There is a positive correlation between them. It is the risk factor respectively and combined the predictors have a higher predictive value. In Sever Early-onset Pre-eclampsia, the number CYS-C≥1.29 mg/L, UA≥420.00 μmol/L, CREA≥59.10 μmol/L, BUN≥5.94 mmol/L, can serve as good indicators for complicating pregnancy. Complicating pregnancy at the right time by clinical comprehensive assessment is necessary.