Correlation research between serum hs-CRP, Hcy, UA and carotid atherosclerosis of patients with essential hypertension

Objective To investigate the correlation between serum hs-CRP, Hcy, UA and carotid atherosclerosis in patients with hypertension. Methods Total 120 patients with hypertensive in our hospital from January 2015 to August 2017 were selected as research object and divided into carotid atherosclerosis group (60 cases, IMT>0.9 mm) and normal group (60 cases, IMT≤0.9 mm) according to carotid artery intima-media thickness (IMT). The carotid atherosclerosis group was divided into intimal thickening group (30 cases, 0.9 mm Results The blood glucose, TG, TC, HDL and LDL levels of carotid atherosclerosis group were not significantly different compared with those of normal group (P>0.05). The hs-CRP, Hcy, UA levels of carotid atherosclerosis group were significantly higher than those of normal group (P<0.05).The levels of hs-CRP, Hcy and UA in intimal thickening group were significantly lower than those of intimal plaque group (P<0.05). The hs-CRP, Hcy and UA levels of intimal stable plaque group were significantly lower than those of intimal unstable plaque group (P<0.05). Conclusion Serum hs-CRP, Hcy and UA levels could reflect the carotid atherosclerosis severity of patients with hypertension. The higher the serum hs-CRP, Hcy and UA levels, the severer carotid atherosclerosis in patients. The three indexes have predictive value on the hypertensive neck.