Objective To observe on the clinical effect of Qianzhi capsule combined with Gynecological Qianjin capsule on the treatment of abnormal vaginal bleeding after IUD implantation.
Methods A total of 135 patients with abnormal vaginal bleeding after IUD implantation were researched from February 2016 to February 2018. All the patients were divided into the control group(
n=45), the study group 1(
n=45) and the study group 2(
n=45). The control group were not given medication. The study group 1 were given Gongxuening capsule orally. The study group 2 were given Qianzhi capsule and Gynecological Qianjin capsule orally. The levels of hemoglobin and serum TNF-α, IL-6 and IL-8 were compared between the different groups before and after treatment. The adverse drug reactions during treatment were recorded and the improvement of abnormal vaginal bleeding and the removal of IUD were observed.
Results The serum levels of TNF-α, IL-6 and IL-8 in study group 2 were significantly lower than those in study group 1 and control group after treatment (
P<0.05). The level of hemoglobin in study group 2 was significantly higher than those in study group 1 and control group after treatment (
P<0.05). After treatment, the duration of menstruation was significantly shorter than those of study group 1 and control group, and the amount of menstrual bleeding was significantly less than those of study group 2 and control group (
P<0.05). The improvement rates of abnormal vaginal bleeding (100.00% and 97.78%) in study group 1 and study group 2 were significantly higher than that in control group (80.00%),
P<0.05, and the removal rate of IUD (0.00% and 2.22%) was significantly lower than that in control group (20.00%),
P<0.05. There was no significant difference in the overall incidence of adverse drug reactions among the groups (
P>0.05).
Conclusion Qianzhi capsule combined with Gynecological Qianjin capsule can significantly reduce the intensity of inflammation in patients with abnormal vaginal bleeding after IUD implantation, increase the content of hemoglobin, shorten the improvement cycle of abnormal vaginal bleeding symptoms, improve the continuation rate of patients with IUD, and do not increase adverse drug reactions.
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