The value of different inflammatory indicators in children with Kawasaki disease

Objective To analysis the results of white blood cell count(WBC), C-reactive protein(CRP), procalcitonin(PCT) and erythrocyte sedimentation rate(ESR) in children with Kawasaki disease(KD), and to explore its value in diagnosis of KD and prediction of KD with coronary artery injury(CAL) damage. Methods From July to December 2018, 56 children with KD in our Hospital were selected as KD group, including 31 children with coronary artery lesion(CAL) and 25 children with non coronary artery lesion(NCAL). Children with pneumonia who had a fever for 5-7 days in the same period were selected as the infection group(40 cases), and 32 healthy children received health screening were selected as the health group. The levels of WBC, CRP, PCT and ESR were measured by automatic white blood cell count、immunofluorescence dry quantitative method and Westergren, respectively. The relationships between those indicators and CAL were analyzed. Results The levels of WBC, CRP, PCT and ESR in children of KD group were significantly higher than those in infection group and health group[WBC(×10⁹/L):19.22±6.43 vs. 10.89±4.56, 8.48±2.15; CRP(mg/L):100.29±75.86 vs. 17.03±18.79, 3.94±1.91; PCT(g/L):3.22±6.83 vs. 0.69±1.06, 0.14±0.25; ESR(mm/h):73.36±28.57 vs. 27.45±13.37, 8.59±4.32, all P<0.05]. The levels of WBC, CRP, PCT and ESR in CAL group were significantly higher than those in NCAL group[WBC(×10⁹/L):23.26±6.19 vs. 15.96±4.53; CRP(mg/L):161.11±73.15 vs. 51.24±26.45; PCT(g/L):5.59±9.54 vs. 1.30±2.06; ESR(mm/h):95.20±23.23 vs. 55.74±18.62, all P<0.05]. Conclusion The early elevation of WBC, CRP, PCT and ESR are closely related to KD. The detections of those inflammatory indicators are of important value for predicting CAL, and have great guiding role in early clinical treatment and prognosis evaluation.