Efficacy analysis of recombinant human interferon α-2b spray combined with Reduning injection in the treatment of children with hand, foot and mouth Disease

Objective To investigate the effect of recombinant human interferon α-2 b spray combined with Reduning injection on immune function and serum inflammatory factors in children with hand, foot and mouth disease. Methods A total of 340 children with hand, foot and mouth disease admitted to Zhengzhou Central Hospital from February 2016 to August 2018 were randomly divided into two groups according to random number method, each group of 170 cases. The control group was treated with recombinant human interferon α-2 b spray(20 mL, 3 times/day), and the observation group was treated with Reduning injection on the basis of the control group(0.6-0.8 mL/kg, 1 time/day). SPSS 23.0 statistical software was used to process the data and compare the clinical signs, immune function and serum inflammatory factors of the two groups before and after treatment. Results After treatment, the antipyretic time of the observation group(0.97±0.16) d was lower than that of the control group(1.75±0.39) d(t=-24.125, P<0.001), and the time of rash regression, healing time of oral ulcer and hospitalization time were shorter than those of the control group(all P<0.05). The levels of CD4⁺, CD4⁺/CD8⁺, and CD8⁺ were improved in the two groups(all P<0.05), but the improvement effect was better in the observation group than those in the control group(all P<0.05). The IgM, IgG and IgA levels in the two groups were significantly increased(all P<0.05), but the levels in the observation group were significantly higher than those in the control group(all P<0.05). The serum levels of CRP, IL-4 and IL-6 in the two groups were significantly reduced(all P<0.05), but the levels in the observation group were significantly lower than those in the control group(all P<0.05). Conclusion Recombinant human interferon alpha-2 b spray combined with Reduning injection in the treatment of pediatric hand, foot and mouth disease can significantly improve the clinical signs, enhance the immune function of children, and reduce the level of serum inflammatory factors. The curative effect is significant, conducive to the recovery of children.