Analysis of clinical and laboratory characteristics of ocular damage in patients with Behcet's syndrome

Objective To understand the clinical and laboratory characteristics of ocular damage in patients with Behcet' s syndrome. Methods The patients admitted to the Department of Rheumatology and Immunology of Peking University People's Hospital from May 2008 to May 2018 were collected to analyze the features of ocular damage and the relationship with other systemic involvement and laboratory indicators. Results Among 101 patients, 35(34.6%) had ocular damage, among which uveitis was the most common(22/35, 62%), followed by cataract(6/35, 17%), conjunctivitis(12%) and keratitis(3/35, 9%). Compared with the group without ocular damage, ocular damage occurred more in men(all P<0.05), and the incidence of heart valve disease and aneurysms was lower(P<0.05). There was no significant difference between the two groups in mucocutaneous, skin, gastrointestinal, nervous system, joint involvement and thrombosis(all P<0.05). The positive rate of anti-endothelial cell antibody(AECA) was lower in the patients with ocular damage group(P<0.05).There was no significant difference between the two groups in increasing of IgG, d-dimmer, ESR, CRP, decreasing of complement, and positive rate of anti-phospholipid antibody(all P<0.05). Conclusion The incidence of ocular damage in patients with Behcet's syndrome is higher in male than female. Among ocular damage, uveitis is most common. Ocular damage is negatively correlated with valvular heart disease and aneurysm, the positive rate of AECA is lower in the patients with ocular damage than those without. Glucocorticoid, immunosuppressants and biological agents can get better results.