Volume 19 Issue 1
Jan.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(1): 14-16,92
WANG Xian-ni, REN Ting-ting, SUN Tang-na, GUO Jun, ZHU Xiao-yu, FAN Shan-hong. Effect of systemic interventions on compliance of patients with neuromyelitis optica spectrum disorder treated with low-dose rituximab[J]. Chinese Journal of General Practice, 2021, 19(1): 14-16,92. doi: 10.16766/j.cnki.issn.1674-4152.001717
Citation: WANG Xian-ni, REN Ting-ting, SUN Tang-na, GUO Jun, ZHU Xiao-yu, FAN Shan-hong. Effect of systemic interventions on compliance of patients with neuromyelitis optica spectrum disorder treated with low-dose rituximab[J]. Chinese Journal of General Practice, 2021, 19(1): 14-16,92. doi: 10.16766/j.cnki.issn.1674-4152.001717
shu

Effect of systemic interventions on compliance of patients with neuromyelitis optica spectrum disorder treated with low-dose rituximab

doi: 10.16766/j.cnki.issn.1674-4152.001717

  • Department of Neurology, Tangdu Hospital, the Air Force Military Medical University, Xi'an, Shaanxi 710038, China

Funds:

 2016JM8033

  • Received Date: 2020-01-18
    Available Online: 2022-02-19
    Abstract
  •   Objective  To investigate the effect of systematic intervention on treatment compliance of patients with neuromyelitis optica spectrum disorder (NMOSD) treated with low-dose rituximab, and to provide evidence to reduce the recurrence rate and improve the treatment effect.   Methods  Eighty-nine NMOSD patients treated in Tangdu Hospital of Air Force Military Medical University from September 2014 to September 2019 were selected and randomly divided into observation group (46 cases) and control group (43 cases). Routine treatment and nursing were given to the control group, and systematic intervention measures were implemented to the observation group. Treatment compliance, annual recurrence rate (ARR) and number of recurrent patients in the 2 groups were compared. The improved neurological function of the patients was evaluated by the Clinical Extended Disability Scale (EDSS) and the Daily Living Ability Scale (ADL).   Results  The treatment compliance of patients in the observation group was 100.00%, significantly higher than that of the control group (81.40%), and the difference was statistically significant (P=0.002). The annual recurrence rate in the observation group was 0.23±0.16, lower than that in the control group (0.56±0.15, P=0.002). The EDSS score of the observation group at 1 year after the induction period was (1.71±0.69) points, which was significantly lower than that of the control group [(2.36±1.25) points, P=0.017]. At 1 year after the induction period, the ADL score of patients in the observation group was (78.25±10.83) points, which was significantly higher than that of the control group [(71.12±10.12) points, P=0.046].   Conclusion  Systematic intervention can effectively improve the disease awareness and treatment compliance of NMOSD patients, and has positive clinical significance for reducing disease recurrence, improving neurological function and improving quality of life.

     

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