Volume 19 Issue 1
Jan.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(1): 38-41
LIU Shi-hua, ZHANG Chao, TIAN Zhi-gang, HOU Wen-zhe, ZHONG Ping. Expression and clinical significance of serum S-100β protein in patients with white matter ischaemic lesions[J]. Chinese Journal of General Practice, 2021, 19(1): 38-41. doi: 10.16766/j.cnki.issn.1674-4152.001724
Citation: LIU Shi-hua, ZHANG Chao, TIAN Zhi-gang, HOU Wen-zhe, ZHONG Ping. Expression and clinical significance of serum S-100β protein in patients with white matter ischaemic lesions[J]. Chinese Journal of General Practice, 2021, 19(1): 38-41. doi: 10.16766/j.cnki.issn.1674-4152.001724
shu

Expression and clinical significance of serum S-100β protein in patients with white matter ischaemic lesions

doi: 10.16766/j.cnki.issn.1674-4152.001724

  • Department of Neurology, Suzhou Municipal Hospital, Affiliated of Anhui Medical University, Suzhou, Anhui 234000, China

Funds:

 1804h08020258

 SZ2017GG43

  • Received Date: 2020-07-24
    Available Online: 2022-02-19
    Abstract
  •   Objective  To explore the expression level of serum S-100β protein in patients with white matter ischaemic lesions (WMIL) and its relationship with WMIL.  Methods  Patients with WMIL, as confirmed by craniocerebral magnetic resonance, from June 2017 to September 2019 were selected as the research subjects, and the degree of white matter lesions was evaluated on the basis of the Fazekas rating scale. Those with normal craniocerebral magnetic resonance matched with age and sex during the same period were selected as the control group. Serum S-100β protein concentrations were detected with enzyme-linked immunosorbent assays. The general clinical data and S-100β protein levels were compared between the two groups. Spearman rank correlation was used to analyse the relationship between the serum S-100β protein level and degree of white matter lesions, and multivariate Logistic regression was used to analyse the influencing factors of WMIL.  Results  Compared with the control group, the proportion of patients with hypertension (79.1% vs. 42.0%, P < 0.001), the proportion of patients with diabetes (34.8% vs. 15.9%, P=0.006) and the level of S-100β protein [(1.414±0.260) pg/mL vs. (0.961±0.316) pg/mL, P < 0.001] in the WMIL group were significantly higher, and the differences were statistically significant. The serum S-100β protein level of patients in WMIL group was significantly and positively correlated with the Fazekas score (r=0.736, P < 0.001). Multivariate logistic regression analysis showed that hypertension, diabetes and elevated S-100β protein levels were independent risk factors for WMIL (all P < 0.01).  Conclusion  The expression level of serum S-100β protein is increased in WMIL patients and positively correlated with the severity of WMIL. The elevated serum S-100β protein level might be an independent risk factor for WMIL, which might be an effective biological marker of chronic white matter damage.

     

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