Volume 19 Issue 1
Jan.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(1): 49-51,136
TONG Xi, DING Cheng, PU Li-li, LYU Chen-yi, ZHANG Lei, LI Xiao-fang, MA Qiu-jun. Correlation between gingival crevicular fluid adiponectin level, inflammation and periodontal index in patients with periodontitis and type 2 diabetes[J]. Chinese Journal of General Practice, 2021, 19(1): 49-51,136. doi: 10.16766/j.cnki.issn.1674-4152.001727
Citation: TONG Xi, DING Cheng, PU Li-li, LYU Chen-yi, ZHANG Lei, LI Xiao-fang, MA Qiu-jun. Correlation between gingival crevicular fluid adiponectin level, inflammation and periodontal index in patients with periodontitis and type 2 diabetes[J]. Chinese Journal of General Practice, 2021, 19(1): 49-51,136. doi: 10.16766/j.cnki.issn.1674-4152.001727
shu

Correlation between gingival crevicular fluid adiponectin level, inflammation and periodontal index in patients with periodontitis and type 2 diabetes

doi: 10.16766/j.cnki.issn.1674-4152.001727
  • 1.

    Department of Stomatology, Jinhua Central Hospital, Jinhua, Zhejiang 321000, China

Funds:

 2019KY497

  • Received Date: 2020-07-30
    Available Online: 2022-02-19
    Abstract
  •   Objective  To investigate the correlation of the adiponectin (APN) level in gingival crevicular fluid, inflammation response and periodontal index in patients with periodontitis and type 2 diabetes (T2DM).  Methods  Fifty healthy patients from January 2018 to December 2019 were selected as group A. At the same period, 50 patients with simple periodontitis admitted to the Department of Stomatology, Jinhua Central Hospital, and Department of Stomatology, Hangzhou Second People's Hospital, were selected as group B, and 50 patients with periodontitis and T2DM were selected as group C. The blood glucose, APN, periodontal index and inflammatory factor level of the three groups were compared, and the correlation between the inflammatory factor level and periodontal index of the gingival crevicular fluid APN level in patients with periodontitis and T2DM was analysed by the Pearson method.  Results  The blood glucose level of gingival crevicular fluid in group C was significantly higher than that in groups A and B (all P < 0.05); the APN level of gingival crevicular fluid in groups B and C was significantly lower than that in group A (all P < 0.05), and the APN level in group C was significantly lower than that in group B (P < 0.05); the levels of monocyte chemotactic protein-1 (MCP-1), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in groups B and C were significantly higher than those in group A (all P < 0.05), and group C was significantly higher than group B (all P < 0.05); plaque index (PLI), bleeding index (SBI), loss of attachment (AL) and depth of exploration (PD) in groups B and C were significantly higher than those in group A (all P < 0.05), and group C was significantly higher than group B (all P < 0.05); the level of gingival crevicular fluid APN in patients with periodontitis and T2DM was negatively correlated with MCP-1, TNF-α, IL-6, PLI, SBI, AL and PD (r=-0.464, -0.471, -0.571, -0.319, -0.518, -0.515, -0.430, all P < 0.05).  Conclusion  The level of APN increases in patients with periodontitis, and its level further increases in patients with periodontitis and T2DM, and the APN level is closely related to inflammation and periodontal symptoms in patients with periodontitis and T2DM.

     

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