Volume 19 Issue 1
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LIAO Zhao-liang, DONG Hai-yan, LU Zhen-chan. Clinical factors of the collateral formation of unilateral atherosclerotic middle cerebral artery occlusion[J]. Chinese Journal of General Practice, 2021, 19(1): 59-61. doi: 10.16766/j.cnki.issn.1674-4152.001730
Citation: LIAO Zhao-liang, DONG Hai-yan, LU Zhen-chan. Clinical factors of the collateral formation of unilateral atherosclerotic middle cerebral artery occlusion[J]. Chinese Journal of General Practice, 2021, 19(1): 59-61. doi: 10.16766/j.cnki.issn.1674-4152.001730
shu

Clinical factors of the collateral formation of unilateral atherosclerotic middle cerebral artery occlusion

doi: 10.16766/j.cnki.issn.1674-4152.001730
  • 1.

    Department of Neurology, Cangnan People's Hospital, Wenzhou, Zhejiang 325800, China

Funds:

 2018RC070

  • Received Date: 2020-03-12
    Available Online: 2022-02-19
    Abstract
  •   Objective  To explore the effect of clinical factors and biochemical indexes on the formation of unilateral large-artery atherosclerotic middle cerebral artery occlusion (MCAO) collaterals and to provide basis for its treatment.  Methods  A total of 198 unilateral aortic atherosclerotic patients with MCAO who were hospitalised in the Department of Neurology at Cangnan People's hospital from February 2016 to September 2019 were selected as the research subjects. They were divided into the good collateral (GC) and poor collateral (PC) groups on the basis of the formation of collaterals. The baseline data, medication data and biochemical tests of the two groups were compared. Multivariate logistic regression analysis was used to analyse the independent factors that affected the formation of unilateral aortic MCAO collaterals.  Results  Forty-eight cases were included in the GC group, and 150 cases were included in the PC group. The high-density lipoprotein (HDL) level in the GC group was (1.21±0.14) mmol/L, which was higher than that in the PC group [(0.94±0.11) mmol/L, t=13.810, P < 0.05]; the low-density lipoprotein (LDL), homocysteine (Hcy) and fasting blood glucose levels in the GC group were (2.41±0.85) mmol/L, (11.52±4.20) mmol/L and (5.45±1.84) mmol/L, respectively, whereas those in the PC group were (2.93±0.89) mmol/L, (13.71±4.06) mmol/L and (6.02±1.39) mmol/L, respectively, and the difference was statistically significant (t=3.560, 3.226, 2.276, respectively, P < 0.05). The National Institutes of Health Stoke Scale (NIHSS) in the GC group was lower than that in the PC group (t=3.201, P < 0.05), and the proportion of statins was higher than that in the PC group (χ2=6.406, P < 0.05). Hypertension, HDL, Hcy, NIHSS and statins affected the formation of collateral circulation of unilateral large-artery atherosclerotic MCAO independently.  Conclusion  Statins and high HDL levels can promote the formation of unilateral aortic MCAO collateral circulation, but high Hcy level and high NIHSS are not conducive to good collateral establishment.

     

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