Volume 19 Issue 1
Jan.  2021
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ZHANG Jun, LIU Juan, HU Jin-hui, WU Rong. Changes in plasma odendmcyte-myelin glycoprotein levels for the diagnosis of brain injury in premature infants[J]. Chinese Journal of General Practice, 2021, 19(1): 69-72. doi: 10.16766/j.cnki.issn.1674-4152.001733
Citation: ZHANG Jun, LIU Juan, HU Jin-hui, WU Rong. Changes in plasma odendmcyte-myelin glycoprotein levels for the diagnosis of brain injury in premature infants[J]. Chinese Journal of General Practice, 2021, 19(1): 69-72. doi: 10.16766/j.cnki.issn.1674-4152.001733
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Changes in plasma odendmcyte-myelin glycoprotein levels for the diagnosis of brain injury in premature infants

doi: 10.16766/j.cnki.issn.1674-4152.001733

  • Department of Paediatrics, Huai'an Maternity and Child Health Care Hospital, Yangzhou University, Huai'an, Jiangsu 223002, China

Funds:

 H2018009

  • Received Date: 2020-06-25
    Available Online: 2022-02-19
    Abstract
  •   Objective  To investigate the relationship between brain injury and plasma odendmcyte-myelin glycoprotein (Omgp) levels and neuron-specific enolase (NSE) in premature infants, and analyze its clinical significance in premature infants with brain injury.  Methods  Total 80 cases of premature infants who were hospitalized in the Neonatal Medical Centre of Huai'an Maternal and Child Health Hospital from January 2019 to December 2019 were included in the study. According to the results of craniocerebral imaging, all infants were divided into brain injury group and non-brain injury group. Blood samples were obtained at 6, 72 and 168 h after birth. Levels of NSE and Omgp were detected via ELISA. The predictive value of plasma NSE and Omgp for brain injury in premature infants (BIPI) was analysed.  Results  (1) The NSE and Omgp levels in the brain injury group were significantly higher than that in the non-brain injury group at 6, 72 and 168 h after birth. (2)The area under ROC curve of OMgp level at 6 h after birth was the largest, which was 0.952, Yoden index was 0.813, sensitivity was 87.50%, specificity was 93.75%. The corresponding optimal threshold was 57.971, positive predictive value was 97.22%, and negative predictive value was 75.03%, which was higher than NSE. (3)The levels of Omgp at 6, 72 and 168 h were significantly negatively correlated with the NBNA score at 40 weeks of corrected gestational age (r=-0.728, -0.732 and -0.752, respectively; all P < 0.01). Levels of NSE had no significant correlation with prognosis at 6, 72 and 168 h after birth (all P>0.05) but could predict the prognosis.  Conclusion  Levels of NSE and Omgp at 6 h after birth are all correlated with BIPI and can be used as potential diagnostic markers. The diagnostic accuracy of Omgp level is higher. The Omgp levels at 6, 72 and 168 h after birth may be a good biomarker for predicting BIPI prognosis.

     

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