Volume 19 Issue 1
Jan.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(1): 73-76,107
LIN Yi-he, ZHUANG Xiao-ping, JIN Wei-wei. Expression of miR-30b and miR-96 in endometrial carcinoma and their relationship with prognosis[J]. Chinese Journal of General Practice, 2021, 19(1): 73-76,107. doi: 10.16766/j.cnki.issn.1674-4152.001734
Citation: LIN Yi-he, ZHUANG Xiao-ping, JIN Wei-wei. Expression of miR-30b and miR-96 in endometrial carcinoma and their relationship with prognosis[J]. Chinese Journal of General Practice, 2021, 19(1): 73-76,107. doi: 10.16766/j.cnki.issn.1674-4152.001734
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Expression of miR-30b and miR-96 in endometrial carcinoma and their relationship with prognosis

doi: 10.16766/j.cnki.issn.1674-4152.001734

  • Western medicine gynecology of Western medicine Wenzhou integrated Chinese and Western medicine hospital, Wenzhou, Zhejiang 325000, China

Funds:

 2017KY630

  • Received Date: 2019-09-09
    Available Online: 2022-02-19
    Abstract
  •   Objective  The levels of miR-30b and miR-96 in peripheral blood mononuclear cells (PBMC) in patients with endometrial carcinoma (EC) were detected to explore their relationship with clinicopathology and prognosis.  Methods  A total of 76 EC patients and healthy outpatients(control group)admitted to Wenzhou hospital of integrated traditional Chinese and western medicine were selected. The expression levels of miR-30b and miR-96 in PBMC were detected by fluorescence quantitative PCR, the correlation was analyzed by Pearson method, the relationships between miR-30b and miR-96 expression levels in PBMC and 5-year survival rate of EC patients were analyzed by Kaplan-Meier method, and the risk factors affecting the prognosis of EC patients were analyzed by Cox regression.  Results  The expression levels of miR-30b and miR-96 in PBMC of EC patients were higher than those of control group (t=21.913, 24.188, all P < 0.05). They were positively correlated (r=0.553, P < 0.05), and correlated with pathological grade, FIGO stage, depth of muscle invasion and lymph node metastasis (P < 0.05). The 5-year overall survival rate of patients with high expression of miR-30b (16.13%) was lower than that of patients with low expression (66.67%, χ2=16.890, P < 0.05). The 5-year overall survival rate of patients with high expression of miR-96 (18.18%) was lower than that of patients with low expression (67.44%, χ2=16.307, P < 0.05). Levels of miR-30b and miR-96, FIGO stage and lymph node metastasis in PMBC were independent risk factors affecting the prognosis of EC patients (HR=2.861, 95% CI: 1.427-5.736; HR=1.973, 95% CI: 1.462-2.663; HR=2.235, 95% CI: 1.491-3.350; HR=2.439, 95% CI: 1.365-4.358; all P < 0.05).  Conclusion  The miR-30b and miR-96 are highly expressed in PMBC, which are related to pathological grade, FIGO stage, muscle invasion, lymph node metastasis and 5-year survival rate of EC patients, and are independent risk factors for adverse prognosis of EC patients.

     

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