Volume 19 Issue 1
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(1): 77-79, 119
YE Ying-ying, WANG Jin-hui, WANG Li-jun, GONG Ai-min. Study on the relationship between serum vitamin D level and gestational diabetes mellitus in pregnant women[J]. Chinese Journal of General Practice, 2021, 19(1): 77-79, 119. doi: 10.16766/j.cnki.issn.1674-4152.001735
Citation: YE Ying-ying, WANG Jin-hui, WANG Li-jun, GONG Ai-min. Study on the relationship between serum vitamin D level and gestational diabetes mellitus in pregnant women[J]. Chinese Journal of General Practice, 2021, 19(1): 77-79, 119. doi: 10.16766/j.cnki.issn.1674-4152.001735
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Study on the relationship between serum vitamin D level and gestational diabetes mellitus in pregnant women

doi: 10.16766/j.cnki.issn.1674-4152.001735

  • Gynaecology, Yuhuan People's Hospital of Zhejiang Province, Yuhuan, Zhejiang 317600, China

Funds:

 2018KY922

  • Received Date: 2019-10-21
    Available Online: 2022-02-19
    Abstract
  •   Objective  To investigate the relationship between serum 25-hydroxyvitamin D [25-(OH)D] level and gestational diabetes mellitus (GDM) in pregnant women, and to analyze the influencing factors of serum 25-hydroxyvitamin D level in pregnant women.  Methods   A random number table was used to select 300 pregnant women who were examined in Yuhuan People's Hospital from September 2017 to December 2018. The levels of 25-(OH)D were detected in the early, middle and late stages of pregnancy. According to the serum levels of 25-(OH)D, the pregnant women were divided into two groups: lack group and no lack group, and the incidence of gestational diabetes was compared between the two groups. According to the serum 25-(OH)D level in the third trimester, the influencing factors of serum 25-(OH)D level in pregnant women were analyzed.  Results   The incidence of gestational diabetes was 26.32% in the lack group and 12.50% in the no lack group, with no statistically significant difference (P>0.05). The incidence of gestational diabetes in the second trimester deficiency group and the no deficiency group were 28.65% and 9.80%, respectively, with statistically significant differences (P < 0.05). The incidence of gestational diabetes was 27.47% and 10.00% in the lack group and no lack group, respectively, with statistically significant differences (P < 0.05). On the basis of univariate analysis, multivariate logistic regression analysis showed that the independent risk factors of serum 25-(OH)D deficiency in pregnant women were less time spent in outdoor activities, winter and spring, no regular vitamin D supplementation, and no timely vitamin D supplementation (all P < 0.05).  Conclusion   Decreased serum 25-(OH)D level in pregnant women may increase the risk of gestational diabetes. Reasonable vitamin D supplementation in early pregnancy can effectively prevent vitamin D deficiency in pregnant women and help reduce the risk of gestational diabetes.

     

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    • References(20)
  • [1]
    谢幸, 孔北华, 段涛. 妇产科学[M]. 9版. 北京: 人民卫生出版社, 2018: 105-109.
    [2]
    ZHU Y Y, ZHANG C L. Prevalence of gestational diabetes and risk of progression to type 2 diabetes: a global perspective[J]. Curr Diab Rep, 2016, 16(1): 7-18. doi: 10.1007/s11892-015-0699-x
    [3]
    ZHANG C L, RAWAL S, CHONG Y S. Risk factors for gestational diabetes: is prevention possible?[J]. Diabetologia, 2016, 59(7): 1385-1390. doi: 10.1007/s00125-016-3979-3
    [4]
    LI Y X, ZHOU L. Vitamin D deficiency, obesity and diabetes[J]. Cell Mol Biol(Noisy-le-grand), 2015, 61(3): 35-38. http://www.researchgate.net/profile/Lei_Zhou62/publication/280033254_Vitamin_D_Deficiency_Obesity_and_Diabetes/links/5959e1ae0f7e9ba95e126c9c/Vitamin-D-Deficiency-Obesity-and-Diabetes.pdf
    [5]
    ANGELLOTTI E, PITTAS A G. The Role of Vitamin D in the prevention of Type 2 diabetes: to D or Not to D?[J]. Endocrinology, 2017, 158(7): 2013-2021. doi: 10.1210/en.2017-00265
    [6]
    刘冰, 洪旭. 血清25羟基维生素D与初诊2型糖尿病患者血糖控制及酮症酸中毒的关系[J]. 中华实用诊断与治疗杂志, 2018, 32(5): 480-482. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZD201805019.htm
    [7]
    HOU W, YAN X T, BAI C M, et al. Decreased serum vitamin D levels in early spontaneous pregnancy loss[J]. Eur J Clin Nutr, 2016, 70(9): 1004-1008. doi: 10.1038/ejcn.2016.83
    [8]
    KIELY M, HEMMINGWAY A, O'CALLAGHAN KM. Vitamin D in pregnancy: current perspectives and future directions[J]. Ther Adv Musculoskelet Dis, 2017, 9(6): 145-154. doi: 10.1177/1759720X17706453
    [9]
    周建烈, 王山米. 孕产妇补充维生素D的研究进展[J]. 中国妇产科临床杂志, 2018, 19(3): 277-279. https://www.cnki.com.cn/Article/CJFDTOTAL-FKLC201803036.htm
    [10]
    冯钰婷, 盛少琴. 妊娠期糖尿病的发病现状及影响因素[J]. 浙江临床医学, 2017, 19(3): 520-521. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGCW201905015.htm
    [11]
    高建瓴, 刘洪. 妊娠中期维生素D水平降低与妊娠期糖尿病相关性研究进展[J]. 陕西医学杂志, 2019, 48(7): 954-957. doi: 10.3969/j.issn.1000-7377.2019.07.041
    [12]
    裴晶晶, 廖祥鹏, 肖建平, 等. 妊娠期妇女维生素D状况与血糖水平关系的分析[J]. 中国妇幼保健, 2016, 31(4): 716-718. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB201604019.htm
    [13]
    韦叙, 莫竞华. 某院妊娠早中期妇女418例维生素D及微量元素状况分析[J]. 现代医药卫生, 2017, 33(3): 424-425. doi: 10.3969/j.issn.1009-5519.2017.03.038
    [14]
    ZHANG M X, PAN G T, GUO J F, et al. Vitamin D deficiency increases the risk of gestational diabetes mellitus: a meta-analysis of observational studies[J]. Nutrients, 2015, 7(10): 8366-8375. doi: 10.3390/nu7105398
    [15]
    BOUCHER B J. Early pregnancy maternal vitamin D concentrations and risk of gestational diabetes mellitus[J]. Paediatr Perinat Epidemiol, 2015, 29(3): 196-199. doi: 10.1111/ppe.12187
    [16]
    BOYLE V T, THORSTENSEN B E, MOURATH D, et al. The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort[J]. Br J Nutr, 2016, 116(8): 1409-1415. doi: 10.1017/S0007114516003202
    [17]
    XIA J, SONG Y, RAWAL S, et al. Vitamin D status during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study in a multiracial cohort[J]. Diabetes Obes Metab, 2019, 21(8): 1895-1905. doi: 10.1111/dom.13748
    [18]
    尹万军, 金丹, 姚梦楠, 等. 维生素D补充对妊娠期糖尿病预防和治疗作用的Meta分析[J]. 卫生研究, 2019, 48(5): 811-816, 821. https://www.cnki.com.cn/Article/CJFDTOTAL-WSYJ201905024.htm
    [19]
    应一樱, 陈洁, 包蓓艳. 维生素D联合西格列汀对2型糖尿病肾病患者尿蛋白水平、骨密度和骨代谢的影响[J]. 中华全科医学, 2019, 17(5): 797-800, 840. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201905026.htm
    [20]
    潘晨萍, 管金丽, 祁玲娥. 妊娠早期25-羟维生素D不足对妊娠期糖尿病的预测价值[J]. 中国计划生育学杂志, 2017, 25(4): 260-262, 266. https://www.cnki.com.cn/Article/CJFDTOTAL-JHSY201704012.htm
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