Volume 19 Issue 1
Jan.  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(1): 83-85, 123
LUO Xiao-dong, LYU Yue-zhong, JIA Xue-zhen, ZHANG Chen. Efficacy and safety of aripiprazole combined with buspirone in the treatment of schizophrenia[J]. Chinese Journal of General Practice, 2021, 19(1): 83-85, 123. doi: 10.16766/j.cnki.issn.1674-4152.001737
Citation: LUO Xiao-dong, LYU Yue-zhong, JIA Xue-zhen, ZHANG Chen. Efficacy and safety of aripiprazole combined with buspirone in the treatment of schizophrenia[J]. Chinese Journal of General Practice, 2021, 19(1): 83-85, 123. doi: 10.16766/j.cnki.issn.1674-4152.001737
shu

Efficacy and safety of aripiprazole combined with buspirone in the treatment of schizophrenia

doi: 10.16766/j.cnki.issn.1674-4152.001737
  • 1.

    Jinhua Second Hospital, Psychiatry Department, Jinhua, Zhejiang 321016, China

Funds:

 81771450

  • Received Date: 2020-05-22
    Available Online: 2022-02-19
    Abstract
  •   Objective   To analyse the efficacy and safety of aripiprazole and buspirone in the treatment of schizophrenia and to explore the effective treatment to improve clinical efficacy.  Methods   A total of 102 schizophrenic patients from April 2019 to April 2020 in the Department of Psychiatry of Jinhua Second Hospital were selected and randomly divided into group A (n=51) and group B (n=51). Groups A and B were treated with aripiprazole and aripiprazole combined with buspirone, respectively. The symptom score (PANSS), cognitive function score (MCCB) and quality of life (SF-36) of the two groups were compared to evaluate clinical efficacy and adverse reactions.  Results   The total score of PANSS in group B (48.81±7.66) was lower than that in group A (64.13±9.55), and the difference was statistically significant (t=8.937, P < 0.001); the MCCB score in group B (48.43±5.09) was higher than that in group A (40.72±5.27), and the difference was statistically significant (t=7.515, P < 0.001); the SF-36 score in group B (77.90±4.13) was higher than that in group A (65.84±4.77), and the difference was statistically significant (t=13.650, P < 0.001); the total effective rate in group B (94.12%) was higher than that in group A (80.39%), and the difference was statistically significant (χ2=4.320, P=0.038); the incidence of adverse reactions in group B (11.76%) was similar to that of group A (9.80%), thereby showing no significant difference (χ2=0.102, P=0.750).  Conclusion   Aripiprazole combined with buspirone is effective in the treatment of schizophrenia. It can reduce the clinical symptoms and improve the cognitive function and quality of life. The total clinical effective rate is high, and it has a certain degree of safety.

     

    • FullText(HTML)
  • loading
    • References(22)
  • [1]
    周聪, 鄢传东, 王鹏. 氯氮平与阿立哌唑治疗精神分裂症的疗效及对肝功能的影响[J]. 中华实用诊断与治疗杂志, 2020, 34(5): 517-519. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZD202005025.htm
    [2]
    孙健, 史丽娜, 胡媛媛. 阿立哌唑联合治疗对奥氮平治疗后体重增加的精神分裂症患者的影响[J]. 现代医药卫生, 2020, 36(7): 1023-1025. doi: 10.3969/j.issn.1009-5519.2020.07.019
    [3]
    汤姿瑛, 凤燕琼, 乔惠君, 等. 丁螺环酮增效治疗慢性精神分裂症阴性症状的随机双盲对照研究[J]. 山西医药杂志, 2020, 49(7): 793-797. doi: 10.3969/j.issn.0253-9926.2020.07.006
    [4]
    戚敏恒, 李立群, 李祎鋆. 小剂量阿立哌唑治疗利培酮所致女性精神分裂症患者高催乳素血症的效果分析[J]. 中国实用医药, 2020, 15(9): 136-138. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSSA202009060.htm
    [5]
    DISANTOSTEFANO J. International Classification of Diseases 10th Revision (ICD-10)[J]. Journal for Nurse Practitioners, 2009, 5(1): 56-57. doi: 10.1016/j.nurpra.2008.09.020
    [6]
    丁亚媛. 首发精神分裂症以阿立哌唑、氨磺必利联用治疗前后的PANSS评分变化分析[J]. 中西医结合心血管病电子杂志, 2019, 7(30): 29, 36. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXJH201930017.htm
    [7]
    程秋霞, 赵徽. 奥氮平、利培酮以及阿立哌唑治疗慢性精神分裂症的临床效果及对患者认知功能的影响[J]. 临床医学研究与实践, 2020, 5(7): 56-57. https://www.cnki.com.cn/Article/CJFDTOTAL-YLYS202007023.htm
    [8]
    梁忠新, 秦轶灵, 严文琼, 等. 阿立哌唑联合认知行为治疗对慢性精神分裂症患者生活质量的影响[J]. 中国医药科学, 2020, 10(5): 287-290. doi: 10.3969/j.issn.2095-0616.2020.05.083
    [9]
    苏晨. 丁螺环酮、阿立哌唑合并利培酮治疗精神分裂症的疗效及对阴性症状及认知功能的影响分析[J]. 现代诊断与治疗, 2019, 30(21): 3750-3751. https://www.cnki.com.cn/Article/CJFDTOTAL-XDZD201921026.htm
    [10]
    苗贞勇. 不同剂量阿立哌唑对首发精神分裂症女性患者服用抗精神病药物致高泌乳素血症的治疗效果[J]. 当代医学, 2020, 26(7): 49-51. doi: 10.3969/j.issn.1009-4393.2020.07.017
    [11]
    唐本玲, 沈尤兰, 田雪入, 等. 利培酮联合盐酸丁螺环酮片改善精神分裂症患者康复期认知功能[J]. 神经损伤与功能重建, 2019, 14(3): 153-155. https://www.cnki.com.cn/Article/CJFDTOTAL-GWKF201903016.htm
    [12]
    张京涛, 刘西和, 王玲玲, 等. 阿立哌唑对女性精神分裂症患者服用奥氮平引起的代谢综合征的临床效果分析[J]. 中国社区医师, 2020, 36(9): 23-24. doi: 10.3969/j.issn.1007-614x.2020.09.012
    [13]
    张长春, 王绍礼, 程伟, 等. 丁螺环酮、阿立哌唑合并利培酮治疗精神分裂症患者的疗效分析[J]. 国际精神病学杂志, 2019, 46(3): 460-462. https://www.cnki.com.cn/Article/CJFDTOTAL-GWYJ201903023.htm
    [14]
    曹峰, 谢渭根. 奥氮平与齐拉西酮治疗精神分裂症的疗效及对糖脂代谢的影响[J]. 中华全科医学, 2020, 18(2): 217-219, 232. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY202002014.htm
    [15]
    陈明菊, 米莉, 罗明, 等. 阿立哌唑联合奥氮平对老年精神分裂症患者临床疗效糖脂代谢的影响[J]. 河北医学, 2020, 26(2): 248-252. doi: 10.3969/j.issn.1006-6233.2020.02.018
    [16]
    孙俊伟, 任虹. 氨磺必利合并丁螺环酮治疗老年痴呆精神行为症状的疗效和安全性回顾性分析[J]. 中国药物与临床, 2019, 19(1): 101-103. https://www.cnki.com.cn/Article/CJFDTOTAL-YWLC201901052.htm
    [17]
    赵云东, 孙连峰, 李士龙, 等. 分析奥氮平联合丁螺环酮治疗精神分裂症阴性症状的疗效及安全性[J]. 北方药学, 2018, 15(10): 158-159. https://www.cnki.com.cn/Article/CJFDTOTAL-BFYX201810128.htm
    [18]
    范连梅, 张美春, 王建勋, 等. 阿立哌唑联合丁螺环酮治疗精神分裂症的临床疗效[J]. 现代医学与健康研究电子杂志, 2018, 2(22): 96-97. https://www.cnki.com.cn/Article/CJFDTOTAL-XYJD201822044.htm
    [19]
    王娟, 王丹, 刘旭恩, 等. 丁螺环酮联合阿立哌唑治疗精神分裂症焦虑症状的临床疗效和安全性[J]. 药物评价研究, 2018, 41(8): 1499-1503. https://www.cnki.com.cn/Article/CJFDTOTAL-YWPJ201808026.htm
    [20]
    王程, 林红, 黄杨梅. 丁螺环酮联合利培酮与劳拉西泮联合利培酮治疗精神分裂症伴有焦虑症状的临床对照研究[J]. 世界最新医学信息文摘, 2017, 17(95): 259-260. https://www.cnki.com.cn/Article/CJFDTOTAL-WMIA201795142.htm
    [21]
    苏明兵, 赵霞, 张璐平, 等. 非典型抗精神病药合并丁螺环酮治疗精神分裂症患者的对照研究[J]. 临床精神医学杂志, 2017, 27(5): 337-339. doi: 10.3969/j.issn.1005-3220.2017.05.017
    [22]
    王海燕. 精神分裂症治疗中阿立哌唑联合丁螺环酮应用效果分析[J]. 人人健康, 2019(9): 228-229. https://www.cnki.com.cn/Article/CJFDTOTAL-RRJK201909236.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(5)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (381) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return