Volume 19 Issue 1
Jan.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(1): 99-102
ZHANG Dao-chun, HUANG Jin-biao, LIU Zi-shan, ZHOU Kai, ZHANG Min-ge, PAN Shan-jun, YU Hai-yan, CHEN Wei-cui. Relationship between the quantitative parameters of diffusion kurtosis imaging and the Ki-67 expression level in rectal adenocarcinoma[J]. Chinese Journal of General Practice, 2021, 19(1): 99-102. doi: 10.16766/j.cnki.issn.1674-4152.001741
Citation: ZHANG Dao-chun, HUANG Jin-biao, LIU Zi-shan, ZHOU Kai, ZHANG Min-ge, PAN Shan-jun, YU Hai-yan, CHEN Wei-cui. Relationship between the quantitative parameters of diffusion kurtosis imaging and the Ki-67 expression level in rectal adenocarcinoma[J]. Chinese Journal of General Practice, 2021, 19(1): 99-102. doi: 10.16766/j.cnki.issn.1674-4152.001741
shu

Relationship between the quantitative parameters of diffusion kurtosis imaging and the Ki-67 expression level in rectal adenocarcinoma

doi: 10.16766/j.cnki.issn.1674-4152.001741
  • 1.

    Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Taizhou, Zhejiang 317000, China

Funds:

 2019RC089

  • Received Date: 2020-09-24
    Available Online: 2022-02-19
    Abstract
  •   Objective  To explore the relationship between quantitative parameters of diffusion kurtosis imaging (DKI) and the molecular markers Ki-67 in patients with rectal adenocarcinoma.  Methods   A total of 43 patients with rectal adenocarcinoma who underwent surgery and did not receive chemoradiotherapy were selected in this retrospective study. The image data included high-resolution MRI, conventional diffusion-weighted imaging and DKI, Mean kurtosis (MK), mean diffusivity (MD) and apparent diffusion coefficient (ADC) were calculated. The patients were divided into the low-Ki-67 group (Ki-67 ≤ 25%) and high-Ki-67 group (Ki-67>25%) on the basis of the Ki-67 level. The difference of each parameter between the two groups was compared. Spearman correlation analysis was applied to confirm the correlation between each parameter value and Ki-67 expression level. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of each parameter.  Results  In the high-Ki-67 group, MK and MD were significantly different compared with those in the low-Ki-67 group [0.88(0.81, 0.94) vs. 1.22(1.06, 1.34), P < 0.01; 1.20(1.12, 1.30)×10-3 mm2/s vs. 1.10(0.94, 1.15)×10-3 mm2/s, P < 0.01]. However, MD showed no difference between the two groups [1.20(1.12, 1.30)×10-3 mm2/s vs. 1.20(1.10, 1.30)×10-3 mm2/s, P>0.05]. MK showed a positive association with the Ki-67 expression level (r=0.523, P < 0.001), whereas ADC showed a negative association with the Ki-67 expression level (r=-0.467, P < 0.01). Compared with MD and ADC, MK showed relatively higher area under the ROC curve of 0.906, sensitivity of 0.97 and specificity of 0.75.  Conclusion  MK and ADC are related to Ki-67 expression, which can indirectly evaluate the proliferation of rectal adenocarcinoma cells. However, MK is superior to ADC in diagnosis efficiency, and can better reflect the invasion and molecular biological characteristics of rectal adenocarcinoma.

     

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