Volume 19 Issue 1
Jan.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(1): 116-119
SUN Mu-yan, LOU Min-fang, ZHENG Yun-hua, ZHOU Jiang-wen, MAO Zhi-yuan, ZHOU Xiao-hua. Effect of Chaihu Guizhi Decoction on somatoform pain disorder and its effect on 5-HT and PGE2[J]. Chinese Journal of General Practice, 2021, 19(1): 116-119. doi: 10.16766/j.cnki.issn.1674-4152.001745
Citation: SUN Mu-yan, LOU Min-fang, ZHENG Yun-hua, ZHOU Jiang-wen, MAO Zhi-yuan, ZHOU Xiao-hua. Effect of Chaihu Guizhi Decoction on somatoform pain disorder and its effect on 5-HT and PGE2[J]. Chinese Journal of General Practice, 2021, 19(1): 116-119. doi: 10.16766/j.cnki.issn.1674-4152.001745
shu

Effect of Chaihu Guizhi Decoction on somatoform pain disorder and its effect on 5-HT and PGE2

doi: 10.16766/j.cnki.issn.1674-4152.001745
  • 1.

    Quzhou Hospital of Traditional Chinese Medicine, Quzhou, Zhejiang 324002, China

Funds:

 浙中医药[2017]22号

 2017ZA143

 2019B092

  • Received Date: 2019-11-07
    Available Online: 2022-02-19
    Abstract
  •   Objective   To explore the clinical effect of Chaihu Guizhi Decoction on patients with somatoform pain disorder and the effect of 5-HT and PGE2 in blood.   Methods  A total of 64 patients with somatoform pain disorder admitted to Quzhou Hospital of Traditional Chinese Medicine and Quhua hospital from January 2017 to February 2019 were selected and randomly divided into study group given Chaihu Guizhi Decoction orally and control group given duloxetine with 32 cases each by numerical table method. Both groups were treated with psychotherapy, the cured duration was 8 weeks. Depressive symptom severity scale (PHQ-9), Generalized anxiety inventory (GAD-7), McGill pain scale (SF-MPQ), comprehensive assessment of quality of life (GQOLI-74) and effective rate were used to evaluate depression, anxiety, pain levels, and quality of life improvement of the 2 groups before and after treatment. The blood levels of 5-HT and PGE2 were monitored before and 8 weeks after treatment. All patients were followed up for 6 months.   Results  The scores of PRI, VAS, PPI, PHQ-9, GAD-7 and GQOLI-74 of 2 groups were not statistically significant (all P>0.05) before treatment and 8 weekends after treatment. The scores of PRI, VAS, PPI, GQOLI-74 total score of 2 groups were statistically significant (all P < 0.05), study group was superior to control group. At the end of 8 weeks, there was no significant difference in efficiency between the two groups (χ2=0.172, P=0.679), no significant adverse reactions occurred in the study group. The serum PGE2 level in the study group was statistically different from that in the control group, while 5-HT level was not statistically different from that before treatment.   Conclusion  Chaihu Guizhi Decoction has the same short-term effect as duloxetine in the treatment of SPD, and the long-term effect is significant.

     

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    • References(21)
  • [1]
    王永芳. 文拉法辛缓释剂治疗躯体形式疼痛障碍疗效观察[J]. 中国药物与临床, 2019, 19(18): 3148-3150. https://www.cnki.com.cn/Article/CJFDTOTAL-YWLC201918037.htm
    [2]
    潘江艳, 杨盼, 韦鑫, 等. 度洛西汀联合加巴喷丁治疗躯体形式疼痛障碍疗效分析[J]. 国际精神病学杂志, 2017, 44(1): 75-78. https://www.cnki.com.cn/Article/CJFDTOTAL-GWYJ201701021.htm
    [3]
    陈国统, 何杨伟, 汪碧云. 柴胡龙骨牡蛎汤加减结合抗焦虑抑郁药物对躯体化焦虑、抑郁状态的疗效及机制分析[J]. 中华中医药学刊, 2017, 35(3): 758-760. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201703070.htm
    [4]
    孙沐炎, 楼敏芳, 汪军华. 柴胡加龙骨牡蛎汤治疗广泛性焦虑症临床观察[J]. 浙江中医药大学学报, 2019, 43(6): 595-598. https://www.cnki.com.cn/Article/CJFDTOTAL-BHON201906019.htm
    [5]
    陈俊名, 徐皓, 赵盛男, 等. 解读躯体症状——重新认识躯体症状障碍[J]. 医学与哲学(B), 2018, 39(9): 63-65. https://www.cnki.com.cn/Article/CJFDTOTAL-YXZL201809021.htm
    [6]
    李欣, 王立伟, 李敬伟, 等. 基于抑郁、焦虑、躯体形式障碍的郁证特质研究[J]. 北京中医药大学学报, 2019, 42(3): 226-234. doi: 10.3969/j.issn.1006-2157.2019.03.008
    [7]
    任婉文, 周志英, 徐密密, 等. 浮针疗法与度洛西汀治疗持续的躯体形式疼痛障碍的临床研究[J]. 中国中西医结合杂志, 2016, 36(2): 166-171. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXJ201602009.htm
    [8]
    符少剑, 姚乾坤, 卓东炳, 等. 度洛西汀肠溶胶囊联合艾司西酞普兰片治疗老年躯体形式障碍的临床研究[J]. 中国临床药理学杂志, 2019, 35(22): 2840-2843. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ201922018.htm
    [9]
    吴江, 贾建平. 神经病学[M]. 北京: 人民卫生出版社, 2015: 481-483.
    [10]
    林炽甄, 郑义侯. 郑义侯教授从肝论治躯体化障碍经验[J]. 四川中医, 2017, 35(5): 8-10. https://www.cnki.com.cn/Article/CJFDTOTAL-SCZY201705004.htm
    [11]
    李永乐. 论《黄帝内经》中肝与情志的多重关系[J]. 中国中医基础医学杂志, 2016, 22(2): 154-155. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJC201602004.htm
    [12]
    尹湘君, 程发峰, 穆杰, 等. 王庆国教授应用柴胡桂枝汤治疗杂病五则[J]. 环球中医药, 2019, 12(7): 1105-1107. doi: 10.3969/j.issn.1674-1749.2019.07.034
    [13]
    王小勇. 柴胡桂枝汤临床新应用[J]. 中国民间疗法, 2018, 26(5): 42. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMJL201805037.htm
    [14]
    丁玲, 崔向宁. 柴胡桂枝汤临床应用及研究概述[J]. 辽宁中医药大学学报, 2018, 20(10): 212-216. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB201810069.htm
    [15]
    查政. 柴胡桂枝汤在神志病治疗中的运用及机理探讨[J]. 国医论坛, 2017, 32(2): 4-7. https://www.cnki.com.cn/Article/CJFDTOTAL-GYLT201702004.htm
    [16]
    王振亮. 张仲景理法方药临床应用[M]. 北京: 中国中医药出版社, 2018: 276-277.
    [17]
    邓玮瑜, 曾胜田, 庄纯. 度洛西汀联合加巴喷丁治疗老年患者躯体形式疼痛障碍的效果[J]. 中国老年学杂志, 2018, 38(11): 2662-2664. doi: 10.3969/j.issn.1005-9202.2018.11.042
    [18]
    李乾元, 周秀扣, 方征宇. 自拟中药汤剂对早期低位肛周脓肿患者临床症状以及炎症反应的改善作用分析[J]. 中华全科医学, 2019, 17(7): 1191-1193, 1217. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201907037.htm
    [19]
    金建峰, 张经纬. 扎冲十三味丸对肩周炎气滞血瘀证的疗效及血清前列腺素E2(PGE2)和缓激肽水平的影响[J]. 中华中医药学刊, 2019, 37(4): 999-1002. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201904055.htm
    [20]
    郦铮铮, 丛文杰, 郑晓露, 等. 脑卒中后抑郁患者交感神经皮肤反应与血浆多巴胺、5-羟色胺及HAMD评分的相关性分析[J]. 中华全科医学, 2019, 17(3): 384-387. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201903013.htm
    [21]
    马铭婕, 许琪. 抑郁症患者中升高的前列腺素E1与抑郁样行为相关[J]. 基础医学与临床, 2019, 39(4): 483-488. doi: 10.3969/j.issn.1001-6325.2019.04.007
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