Volume 19 Issue 2
Feb.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(2): 179-181, 331
WU An-qi, WANG Lin, YANG Yan-ru. Clinical study of liver cancer resection combined with splenectomy in the treatment of liver cancer complicated with hypersplenism[J]. Chinese Journal of General Practice, 2021, 19(2): 179-181, 331. doi: 10.16766/j.cnki.issn.1674-4152.001761
Citation: WU An-qi, WANG Lin, YANG Yan-ru. Clinical study of liver cancer resection combined with splenectomy in the treatment of liver cancer complicated with hypersplenism[J]. Chinese Journal of General Practice, 2021, 19(2): 179-181, 331. doi: 10.16766/j.cnki.issn.1674-4152.001761
shu

Clinical study of liver cancer resection combined with splenectomy in the treatment of liver cancer complicated with hypersplenism

doi: 10.16766/j.cnki.issn.1674-4152.001761
  • 1.

    Surgical Operation Room, First Affiliated Hospital of Air Force Military Medical University, Xi'an, Shaanxi 710032, China

Funds:

 2018ZDXM-SF-061

  • Received Date: 2020-06-18
    Available Online: 2022-02-19
    Abstract
  •   Objective  To investigate the clinical effect of liver cancer resection combined with splenectomy in patients with liver cancer complicated with hypersplenism.  Methods  Total 118 patients with primary liver cancer with spleen hypersplenism were Selected from February 2015 to February 2017 in our hospital, according to the operation method, who were divided into joint resection of liver and spleen group (observation group, 66 cases) and simple hepatic resection group (control group, 52 cases). Intraoperative blood loss and transfusion volume, red blood cell (RBC), white blood cell (WBC), platelet (PLT), CD4+, CD8+, CD4+/CD8+ and other T cell subtypes before and after surgery were compared between the two groups. Postoperative complications were compared between the two groups, and survival of the two groups was compared after 3 years of follow-up.  Results  There was no significant difference in intraoperative blood loss and blood transfusion between the two groups (all P>0.05). There were no statistically significant differences in RBC, WBC, PLT, CD4+, CD8+, CD4+/CD8+ and other indicators between the two groups 1 week before surgery (all P>0.05). The WBC and PLT indicators in the observation group were significantly higher than those in the control group 2 weeks after surgery (all P < 0.01), and the CD4+ and CD4+/CD8+ indicators in the observation group were significantly higher than those in the control group 2 months after surgery (all P < 0.01). The incidence of pulmonary infection, pleural effusion, biliary leakage, gastrointestinal bleeding and other complications in the observation group was 15.15%(10/66), while that in the control group was 11.54%(6/52). The incidence of postoperative complications in the two groups was not statistically significant (χ2=0.324, P=0.569). After 3 years of postoperative follow-up, the tumor-free survival rate of the observation group was 40.91%(27/66) and that of the control group was 21.15%(11/52), and the tumor-free survival rate of the observation group was significantly higher than that of the control group (χ2=5.199, P=0.023).  Conclusion  Combined splenectomy for hepatocellular carcinoma with hypersplenism can effectively promote the rise of WBC and PLT, enhance the immune function of the body, improve the long-term treatment effect, and is relatively safe, which is worthy of clinical promotion and use.

     

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