Volume 19 Issue 2
Feb.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(2): 221-223, 273
ZHANG Li-yuan, CHEN Xiang-yi, WU Hui-ming. Effects of Shujin Songjian topical liniment on the prevention and treatment of advanced knee osteoarthritis and its influence on serum bFGF level and knee joint function recovery[J]. Chinese Journal of General Practice, 2021, 19(2): 221-223, 273. doi: 10.16766/j.cnki.issn.1674-4152.001772
Citation: ZHANG Li-yuan, CHEN Xiang-yi, WU Hui-ming. Effects of Shujin Songjian topical liniment on the prevention and treatment of advanced knee osteoarthritis and its influence on serum bFGF level and knee joint function recovery[J]. Chinese Journal of General Practice, 2021, 19(2): 221-223, 273. doi: 10.16766/j.cnki.issn.1674-4152.001772
shu

Effects of Shujin Songjian topical liniment on the prevention and treatment of advanced knee osteoarthritis and its influence on serum bFGF level and knee joint function recovery

doi: 10.16766/j.cnki.issn.1674-4152.001772
  • 1.

    Department of Orthopaedics and Orthopaedics, Wenzhou Traditional Chinese Medicine Hospital, Wenzhou, Zhejiang 325000, China

Funds:

 ZX-01-C2016036

  • Received Date: 2020-05-26
    Available Online: 2022-02-19
    Abstract
  •   Objective  To investigate the effects of Shujin Songjian topical liniment on the treatment of advanced knee osteoarthritis (KOA).  Methods  Seventy-four patients with advanced KOA who were diagnosed and treated between January 2017 and June 2019 were divided into a treatment group (n=37) and a control group (n=37) via the random number table method. The control group was treated with total knee arthroplasty (TKA) and given routine treatment after surgery. On the 7th day after surgery, the treatment group was externally applied with Shujin Songjian topical liniment. The curative effect of this agent was evaluated after 28 days of medication. Scores of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Rasmussen grading were calculated and statistically analysed before and after treatment. Levels of serum bone gla protein (BGP), vascular endothelial cell growth factor (VEGF) and basic fibroblast growth factor (bFGF) were determined via enzyme-linked immunosorbent assay.  Results  The total effective rate in the treatment group (97.30%) was significantly higher than that in the control group (78.38%, P < 0.05). The WOMAC scores, serum VEGF and bFGF levels in the two groups significantly decreased after treatment (all P < 0.05), whereas serum BGP levels and Rasmussen grading scores significantly increased (all P < 0.05). After treatment, WOMAC scores, serum VEGF and bFGF levels of the treatment group were significantly lower, whereas serum BGP levels and Rasmussen grading scores were significantly higher than those of the control group (all P < 0.05).  Conclusion  External application of Shujin Songjian topical liniment can effectively improve the effects of TKA on patients with advanced KOA, reduce the symptoms of osteoarthritis and the level of bFGF and improve knee joint functions.

     

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