Volume 19 Issue 2
Feb.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(2): 236-240
WANG Wei, WU Wei, GAO Feng, WANG Bin. Changes and clinical significance of serum STREM-1 and sCD163 levels in patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Chinese Journal of General Practice, 2021, 19(2): 236-240. doi: 10.16766/j.cnki.issn.1674-4152.001776
Citation: WANG Wei, WU Wei, GAO Feng, WANG Bin. Changes and clinical significance of serum STREM-1 and sCD163 levels in patients with acute exacerbation of chronic obstructive pulmonary disease[J]. Chinese Journal of General Practice, 2021, 19(2): 236-240. doi: 10.16766/j.cnki.issn.1674-4152.001776
shu

Changes and clinical significance of serum STREM-1 and sCD163 levels in patients with acute exacerbation of chronic obstructive pulmonary disease

doi: 10.16766/j.cnki.issn.1674-4152.001776

  • Department of Respiratory, Wangjing Hospital of CACMS, Beijing 100102, China

Funds:

 Z181100001718114

  • Received Date: 2020-07-06
    Available Online: 2022-02-19
    Abstract
  •   Objective  To investigate the changes of serum soluble myeloid cell trigger receptor 1 (sTREM-1) and soluble hemoglobin scavenger receptor (sCD163) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and analyze their diagnostic value for the prognosis of patients with AECOPD.  Methods  Total 124 AECOPD patients admitted to our hospital from May 2017 to August 2019 were selected and divided into deterioration group (32 cases) and good conversion group (92 cases) according to the clinical outcome after 28 d of hospitalization. Another 50 healthy people were selected as the control group. Serum sTREM-1 and sCD163 levels were detected by enzyme linked immunosorbent assay. Clinical data of the patients were collected, and factors affecting the prognosis of AECOPD patients were analyzed by Logistic stepwise regression. The prognostic value of STREM-1 and sCD163 in AECOPD patients was analyzed by receiver operator characteristics curve (ROC).  Results  Serum STREM-1 and sCD163 levels in the deterioration group were higher than that in the good conversion group and control group (all P < 0.05), and the good conversion group was higher than control group (all P < 0.05). Logistic stepwise regression analysis results showed that the acute physiology and chronic health conditions (APACHE Ⅱ) score, number of acute hospital nearly 1 years, combined shock, sTREM-1, sCD163 were risk factors for poor prognosis of AECOPD patients (all P < 0.01). ROC analysis results showed that the area under curve (AUC) of sTREM-1, sCD163 and combined sTREM-1+sCD163 in the diagnosis of AECOPD patients were 0.727, 0.730, 0.910, the sensitivity were 68.75%, 62.50%, 84.38%, the specificity were 78.26%, 82.61%, 92.39%.  Conclusion  Elevated sTREM-1 and sCD163 levels may be risk factors for poor prognosis in AECOPD patients, and combined detection of sTREM-1 and sCD163 may help improve the accuracy of prognosis prediction.

     

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