Volume 19 Issue 2
Feb.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(2): 248-251
GUO Li-min, MA Jin, CHEN Ming-wu. A comparative study of paracetamol and ibuprofen on patent ductus arteriosus in preterm infants at different stages of gestational age[J]. Chinese Journal of General Practice, 2021, 19(2): 248-251. doi: 10.16766/j.cnki.issn.1674-4152.001779
Citation: GUO Li-min, MA Jin, CHEN Ming-wu. A comparative study of paracetamol and ibuprofen on patent ductus arteriosus in preterm infants at different stages of gestational age[J]. Chinese Journal of General Practice, 2021, 19(2): 248-251. doi: 10.16766/j.cnki.issn.1674-4152.001779
shu

A comparative study of paracetamol and ibuprofen on patent ductus arteriosus in preterm infants at different stages of gestational age

doi: 10.16766/j.cnki.issn.1674-4152.001779
  • 1.

    Department of Pediatrics, Third Affiliated Hospital of Bengbu Medical College, Suzhou, Anhui 234000, China

Funds:

 1608085MH196

  • Received Date: 2020-05-15
    Available Online: 2022-02-19
    Abstract
  •   Objective  To observe the efficacy and safety of paracetamol and ibuprofen in the treatment of patent ductus arteriosus (PDA) in preterm infants of different gestational ages.  Methods  Total 110 preterm infants with gestational age ≤37 weeks, birthweight ≤2 500 g confirmed PDA were enrolled, including group Ⅰ (ibuprofen group, from January 2016 to January 2018, a total of 56 preterm infants received oral ibuprofen) and group Ⅱ (paracetamol group, from January 2018 to January 2020, a total of 54 preterm infants received oral paracetamol). According to gestational age, all the infants were divided into three groups: 28-30+6 weeks group, 31-33+6 weeks group, 34-36+6 weeks group. The efficacy and safety of the two drugs and the difference of PDA closure rate among the three groups were observed and compared.  Results  There was no significant difference in PDA closure rate between group Ⅰ (78.57%) and Ⅱ (79.63%), P>0.05. The closure rate of PDA were 62.5%, 84.2% and 87.5%, respectively, in 28-30+6 weeks group, 31-33+6 weeks group and 34-36+6 weeks. In addition, oral paracetamol was as safe as oral ibuprofen in terms of gastrointestinal bleeding, retinopathy of prematurity, necrotizing enterocolitis, bronchopulmonary dysplasia, intraventricular hemorrhage, hyperbilirubinemia, uri nary output (all P>0.05).  Conclusion  The efficacy and safety of paracetamol and ibuprofen on PDA are similar. There was no significant difference in the incidence of adverse reactions between the two drugs. The closure rate of patent ductus arteriosus is not equal in different gestational age and is inversely proportional to gestational age.

     

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