Changes and clinical significance of serum IFN-γ and H<sub>2</sub>S levels in children with benign infantile convulsion associated with mild gastroenteritis

ZHANG Ling; TU You-quan; FANG Chun-yan; HUANG Ming-hai

doi:10.16766/j.cnki.issn.1674-4152.001780

Volume 19 Issue 2

Feb. 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(2): 252-255

ZHANG Ling, TU You-quan, FANG Chun-yan, HUANG Ming-hai. Changes and clinical significance of serum IFN-γ and H2S levels in children with benign infantile convulsion associated with mild gastroenteritis[J]. Chinese Journal of General Practice, 2021, 19(2): 252-255. doi: 10.16766/j.cnki.issn.1674-4152.001780

Citation:

ZHANG Ling, TU You-quan, FANG Chun-yan, HUANG Ming-hai. Changes and clinical significance of serum IFN-γ and H₂S levels in children with benign infantile convulsion associated with mild gastroenteritis[J]. Chinese Journal of General Practice, 2021, 19(2): 252-255. doi: 10.16766/j.cnki.issn.1674-4152.001780

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Changes and clinical significance of serum IFN-γ and H₂S levels in children with benign infantile convulsion associated with mild gastroenteritis

doi: 10.16766/j.cnki.issn.1674-4152.001780

Department of Pediatric Neurology, Women and Children's Hospital in Ningbo, Ningbo, Zhejiang 315000, China

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2020KY883

Received Date: 2020-08-06
Available Online: 2022-02-19

Abstract

Abstract

Objective To explore the changes and clinical significance of serum interferon-γ (IFN-γ) and hydrogen sulfide (H₂S) levels in children with benign infantile convulsion associated with mild gastroenteritis (BICE), as well as to explore their roles in the occurrence and development of BICE. Methods A total of 83 BICE children who were treated in Women and Children's Hospital in Ningbo from March 2017 to July 2019 were enrolled as observation group, whereas another 65 healthy controls during the same period were enrolled as control group. The levels of serum IFN-γ and H₂S were detected by ELISA and spectrophotometry. The correlation between serum IFN-γ and H₂S levels and the correlation between the two indices and severity of BICE were analysed by Pearson and Spearman tests. The diagnostic value of serum IFN-γ and H₂S levels for BICE was analysed by ROC curves. Results The levels of serum H₂S and IFN-γ in the observation group were significant different from those in the control group [(30.15±6.09) μmol/L, (5.68±1.13) μg/L vs. (43.28±8.34) μmol/L, (4.25±0.92) μg/L, t=11.066, 8.277, all P < 0.001].They were also correlated with the severity of BICE (all P < 0.05). The AUC values of serum IFN-γ and H₂S levels for diagnosis of BICE were 0.785 and 0.895, respectively. Conclusion The levels of serum IFN-γ and H₂S are relevant in BICE children and associated with disease severity. The serum IFN-γ and H₂S levels are of diagnostic value for BICE.
- Benign infantile convulsion associated with mild gastroenteritis,
- Interferon-γ,
- Hydrogen sulfide,
- Disease severity

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Changes and clinical significance of serum IFN-γ and H₂S levels in children with benign infantile convulsion associated with mild gastroenteritis

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Changes and clinical significance of serum IFN-γ and H2S levels in children with benign infantile convulsion associated with mild gastroenteritis

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Changes and clinical significance of serum IFN-γ and H₂S levels in children with benign infantile convulsion associated with mild gastroenteritis