Volume 19 Issue 2
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CHEN Chun-mian, LIN Chong-guang, JIANG De-guo. Predictive effect of subjective experience of antipsychotic side effects on medication compliance in schizophrenia[J]. Chinese Journal of General Practice, 2021, 19(2): 274-276, 279. doi: 10.16766/j.cnki.issn.1674-4152.001786
Citation: CHEN Chun-mian, LIN Chong-guang, JIANG De-guo. Predictive effect of subjective experience of antipsychotic side effects on medication compliance in schizophrenia[J]. Chinese Journal of General Practice, 2021, 19(2): 274-276, 279. doi: 10.16766/j.cnki.issn.1674-4152.001786
shu

Predictive effect of subjective experience of antipsychotic side effects on medication compliance in schizophrenia

doi: 10.16766/j.cnki.issn.1674-4152.001786
  • 1.

    Nursing Department, The Seventh Hospital of Wenzhou, Wenzhou, Zhejiang 325005, China

Funds:

 2018KY764

 Y20180557

  • Received Date: 2020-11-05
    Available Online: 2022-02-19
    Abstract
  •   Objective  To examine the predictive value of subjective experience of antipsychotic side effects on medication compliance in patients with schizophrenia.  Methods  One hundred and twenty-three patients with schizophrenia completed the Glasgow Antipsychotics Side-effect Scale (GASS) at discharge, and medication compliance follow-up was completed 4-5 weeks after discharge. In the receiver operating curve, the total GASS score was used as the independent variable. The area under the curve was calculated, and the sensitivity and specificity were predicted.  Results  Fifty-two patients (42.3%) were defined as medication non-compliance. The total score of GASS (OR=1.105, 95% CI=1.041-1.173) and the score of extrapyramidal side effect of GASS (OR=7.965, 95% CI=2.371-26.754) were significantly associated with medication non-compliance (all P < 0.01). Receiver operating characteristic curve analysis indicated that the suitable cut-off points on total score of GASS for identifying medication non-compliance was ≥20 (sensitivity and specificity were 92.3% and 66.2%, respectively).  Conclusion  The subjective experience of antipsychotic side effects can be used to predict medication non-compliance in patients with schizophrenia.

     

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