Volume 19 Issue 2
Feb.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(2): 302-304
WU Xu-jie, ZHAO Na, WANG Yi-ru, ZHU Zheng-yu. Clinical curative effect of Shugan Xiehuo Decoction in treating Qiyu Huahuo type post-stroke depression[J]. Chinese Journal of General Practice, 2021, 19(2): 302-304. doi: 10.16766/j.cnki.issn.1674-4152.001794
Citation: WU Xu-jie, ZHAO Na, WANG Yi-ru, ZHU Zheng-yu. Clinical curative effect of Shugan Xiehuo Decoction in treating Qiyu Huahuo type post-stroke depression[J]. Chinese Journal of General Practice, 2021, 19(2): 302-304. doi: 10.16766/j.cnki.issn.1674-4152.001794
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Clinical curative effect of Shugan Xiehuo Decoction in treating Qiyu Huahuo type post-stroke depression

doi: 10.16766/j.cnki.issn.1674-4152.001794

  • Department of Neurology, Wenzhou Hospital of Traditional Chinese medicine, Wenzhou, Zhejiang 325000, China

Funds:

 2017ZB087

  • Received Date: 2020-07-03
    Available Online: 2022-02-19
    Abstract
  •   Objective  To explore the clinical efficacy of Shugan Xiehuo Decoction in treating Type of stagnated qi turning to fire post-stroke depression (PSD).  Methods  A total of 120 patients with Type of stagnated qi turning to fire PSD treated in Wenzhou Hospital of Traditional Chinese Medicine of Zhejiang University from August 2017 to December 2019 were included in this study. According to the random-number table method, the observation and control groups had 60 patients each. Patients in the control group were treated with sertraline hydrochloride tablets, whereas patients in the observation group were treated with Shugan Xiehuo Decoction for 6 weeks. Patients in the two groups were followed-up, and their HAMD score, NIHSS score, Barthel Index score, and TCM syndrome score were observed. The occurrence of adverse reactions during treatment was compared and analysed.  Results  (1) No statistically significant difference in HAMD score, NIHSS score, Barthel index score, and TCM syndrome score was observed between the two groups before treatment (all P>0.05). Improvement was observed after treatment, and this improvement was significantly higher in the observation group than in the control group (tHAMD score=-2.467, P=0.015; tNIHSS score=-5.707, P < 0.001; tBarthel index score=36.258, P < 0.001; tTCM syndrome score=-7.267, P < 0.001). (2) The incidence of adverse reactions was 8.33% in the observation group and 10.00% in the control group, with no significant difference between both groups (χ2=0.100, P=0.752).  Conclusion  Shugan Xiehuo Decoction has a definite effect on the treatment of Type of stagnated qi turning to fire PSD. On the basis of improving patients' depressive symptoms, it has a certain effect on their neurological rehabilitation and further improves patients' quality of life. No serious adverse drug reactions or drug addiction is observed during treatment.

     

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