Volume 19 Issue 3
Mar.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(3): 347-350
ZHAO Xiao-ming, SU Chen-chen, LOU Xiao-xiao, ZHANG Yin-gang. Clinical efficacy of animal bone peptides in promoting fracture healing after PFNA operation[J]. Chinese Journal of General Practice, 2021, 19(3): 347-350. doi: 10.16766/j.cnki.issn.1674-4152.001806
Citation: ZHAO Xiao-ming, SU Chen-chen, LOU Xiao-xiao, ZHANG Yin-gang. Clinical efficacy of animal bone peptides in promoting fracture healing after PFNA operation[J]. Chinese Journal of General Practice, 2021, 19(3): 347-350. doi: 10.16766/j.cnki.issn.1674-4152.001806
shu

Clinical efficacy of animal bone peptides in promoting fracture healing after PFNA operation

doi: 10.16766/j.cnki.issn.1674-4152.001806
  • 1.

    Department of Orthopedics, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China

Funds:

 81371987

  • Received Date: 2020-08-18
    Available Online: 2022-02-19
    Abstract
  •   Objective  To explore the effect of animal bone polypeptide injection on the postoperative fracture healing of senile osteoporosis intertrochanteric fracture after proximal femoral nail antirotation (PFNA).   Methods   A total of 104 senile osteoporotic femoral intertrochanteric fractures admitted to the Department of Orthopedics, the First Affiliated Hospital of Xi'an Jiaotong University from December 2018 to June 2019 were selected. According to the method of random number table, all the patients were divided into the control group (52 cases) and the observation group (52 cases). PFNA surgery was performed in both groups. Patients in the observation group used animal bone polypeptide after surgery, while patients in the control group were treated with conventional basic drug after surgery for comparison. Postoperative pain relief (VAS score), hip fracture healing, postoperative joint function recovery (Harris score), excellent and good fracture healing rate and bone mineral density deposition improvement were compared between the two groups. Adverse complications during follow-up treatment were recorded and the rate was calculated.   Results   All 104 cases were followed up. Compared with the control group, the clinical healing time of postoperative fracture in the observation group was obviously shorter [(11.37±1.35) weeks vs. (12.85±1.76) weeks], the degree of relief of postoperative pain symptoms [(0.21±0.11) vs. (0.83±0.13)] and the degree of functional recovery of hip joint [(86.35±10.51) vs. (75.61±11.32)] in the observation group were also better than those in the control group. Meanwhile, the bone mineral density of different parts in the observation group was higher than that in the control group, and the incidence of postoperative complications was also significantly lower (3.8% vs. 7.7%), all P < 0.05).   Conclusion  Animal bone polypeptide drugs can effectively promote fracture healing, reduce swelling and pain, facilitate the postoperative rehabilitation of hip function, and effectively decrease adverse complications during follow-up treatment such as re-fracture and intramedullary nail loosening. It can be used as a good postoperative supplement for PFNA fixation of intertrochanteric fractures and has extensive clinical value.

     

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