Volume 19 Issue 3
Mar.  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(3): 354-357,462
SONG Yang, XIA Bing, WU Yue-guang. Analysis of related clinical risk factors of lung infection in patients with lung cancer[J]. Chinese Journal of General Practice, 2021, 19(3): 354-357,462. doi: 10.16766/j.cnki.issn.1674-4152.001808
Citation: SONG Yang, XIA Bing, WU Yue-guang. Analysis of related clinical risk factors of lung infection in patients with lung cancer[J]. Chinese Journal of General Practice, 2021, 19(3): 354-357,462. doi: 10.16766/j.cnki.issn.1674-4152.001808
shu

Analysis of related clinical risk factors of lung infection in patients with lung cancer

doi: 10.16766/j.cnki.issn.1674-4152.001808

  • Oncology Surgery, Hangzhou Cancer Hospital, Hangzhou, Zhejiang 310003, China

Funds:

 81301927

  • Received Date: 2020-06-27
    Available Online: 2022-02-19
    Abstract
  •   Objective   To explore the relevant risk factors for lung infection.   Methods   We conducted a retrospective study of 156 lung cancer patients admitted to Hangzhou Cancer Hospital from January 2014 to December 2016. Pulmonary infection was defined as a chest radiograph showing the presence of new or ongoing infiltrating lesions combined with any of the following: new purulent sputum, changes chronic sputum, or fever. Multivariate cox regression analysis was used to explore the risk factors that were significantly related to lung infection.   Results   A total of 60 cases (38.5%) of all study subjects developed pulmonary infections. Until the end of follow-up, the average overall survival rate of patients in the pneumonia group was significantly shorter than that of patients in the non-pneumonia group (48.5% vs. 74.2%, P < 0.05). The overall survival rate of smoking patients was significantly lower than that of never-smokers (32.8% vs. 19.6% vs. 75.4%, P < 0.001). Multivariate analysis showed that age (P=0.001), clinical stage Ⅳ (P=0.045), neutropenia (P < 0.001), and smoking (P=0.020) were independent risk factors for lung infection in patients with lung cancer. A subgroup analysis of patients receiving chemotherapy showed that age (P=0.006), neutral granulocytopenia (P < 0.001), smoking (P=0.030), and second-line therapy (P=0.004) were independent risk factors for the development of pneumonia.   Conclusion   For lung cancer patients, old age, smoking, and neutropenia are significant risk factors affecting their lung infections.

     

    • FullText(HTML)
  • loading
    • References(21)
  • [1]
    王鹏, 张东, 郭学光, 等. 老年非小细胞肺癌患者肺部感染病原学分布与耐药性分析[J]. 现代生物医学进展, 2017, 17(32): 6260-6266. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201732012.htm
    [2]
    郝名浩, 吴畴斌, 石荣跃, 等. 老年中心型肺癌并发阻塞性肺炎的病原学特点及耐药性分析[J]. 现代肿瘤医学, 2018, 26(14): 2203-2205. doi: 10.3969/j.issn.1672-4992.2018.14.015
    [3]
    彭武君, 张文林, 刘君德, 等. 气道定植菌对肺癌患者术后肺部感染的影响因素分析[J]. 中华医院感染学杂志, 2019, 29(4): 508-511. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201904007.htm
    [4]
    XU M Y, CAO B, CHEN Y, et al. Association between Helicobacter pylori infection and tumor markers: an observational retrospective study[J]. BMJ Open, 2018, 8(8): e022374. doi: 10.1136/bmjopen-2018-022374
    [5]
    吴海玲, 刘宁红. 老年肺癌患者医院获得性肺炎临床分析[J]. 中华老年多器官疾病杂志, 2017, 16(1): 43-46. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLQG201701013.htm
    [6]
    YAMAGUCHI F, MINAKATA T, MIURA S, et al. Heterogeneity of latent tuberculosis infection in a patient with lung cancer[J]. J Infect Public Health, 2020, 13(1): 151-153. doi: 10.1016/j.jiph.2019.07.009
    [7]
    LEE P H, LEE T Y, CHANG G C. Hepatitis B flare during osimertinib targeted therapy in a lung cancer patient with a resolved hepatitis B virus infection[J]. Eur J Cancer, 2020, 130: 272-274. doi: 10.1016/j.ejca.2020.02.026
    [8]
    李啸, 徐静. 肺癌与肺炎合并伴胸腔积液患者的急诊疗效及血浆B型钠尿肽、降钙素原水平的变化比较[J]. 中国医药导报, 2018, 15(26): 121-124. https://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201826031.htm
    [9]
    XIONG W M, XU Q P, LI X, et al. The association between human papillomavirus infection and lung cancer: a system review and meta-analysis[J]. Oncotarget, 2017, 8(56): 96419-96432. doi: 10.18632/oncotarget.21682
    [10]
    NAGY A, MULLER V, KOLONICS-FARKAS A M, et al. Worse lung cancer outcome in patients with lower respiratory tract infection confirmed at time of diagnosis[J]. Thorac Cancer, 2019, 10(9): 1819-1826. doi: 10.1111/1759-7714.13153
    [11]
    孙燕, 胡予. 合并症对老年肺癌患者化疗耐受性及生存期的影响[J]. 中国临床医学, 2018, 25(3): 333-339. https://www.cnki.com.cn/Article/CJFDTOTAL-LCYX201803004.htm
    [12]
    KRELING G A D, DAGOSTIN M A, PARK M. Empyema caused by infection with Clostridium septicum in a patient with lung cancer[J]. J Bras Pneumol, 2018, 44(6): 529-531. doi: 10.1590/s1806-37562017000000466
    [13]
    MERCIER T, DESLYPERE G, NACKAERTS K. Ramsay Hunt syndrome: a rare complication of herpes zoster infection in a lung cancer patient[J]. Acta Clin Belg, 2019, 74(5): 355-358. doi: 10.1080/17843286.2018.1517076
    [14]
    高珂, 赖玉田, 黄健, 等. 肺癌肺叶切除患者术前存在气道定植菌与术后肺炎的发生有相关性吗?[J]. 中国肺癌杂志, 2017, 20(4): 239-247. https://www.cnki.com.cn/Article/CJFDTOTAL-FAIZ201704005.htm
    [15]
    GARG N, PUNCH C, STEIN M, et al. When occam's razor can fail- active mycobacteria infection and lung cancer: a case of neuroendocrine lung cancer diagnosed in the setting of refractory mycobacterium avium-intracellulare[J]. Clin Case Rep, 2018, 6(11): 2156-2159. doi: 10.1002/ccr3.1813
    [16]
    CHEN S, LI X, LV H, et al. Prognostic dynamic nomogram integrated with inflammation-based factors for non-small cell lung cancer patients with chronic hepatitis B viral infection[J]. Int J Biol Sci, 2018, 14(13): 1813-1821. doi: 10.7150/ijbs.27260
    [17]
    叶红英, 应俊, 方和敬, 等. 慢性肾衰竭维持性血液透析患者肺部感染的危险因素分析[J]. 中华全科医学, 2018, 16(6): 932-934. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201806023.htm
    [18]
    YAMASAKI M, FUNAISHI K, SAITO N, et al. Small-cell lung cancer comorbid with pulmonary mycobacterium avium infection: a case report[J]. Chemotherapy, 2018, 63(5): 257-261. doi: 10.1159/000494504
    [19]
    彭伟, 陈津, 魏伟, 等. 血清KL-6预测肺癌患者放疗后发生放射性肺炎风险的研究[J]. 中华放射医学与防护杂志, 2017, 37(12): 891-895. doi: 10.3760/cma.j.issn.0254-5098.2017.12.002
    [20]
    TAMURA A, FUKAMI T, HEBISAWA A, et al. Recent trends in the incidence of latent tuberculosis infection in Japanese patients with lung cancer: A small retrospective study[J]. J Infect Chemother, 2020, 26(3): 315-317. doi: 10.1016/j.jiac.2019.10.018
    [21]
    WANG Y H, SHEN X D. Human immunodeficiency virus infection and mortality risk among lung cancer patients: a systematic review and meta-analysis[J]. Medicine(Baltimore), 2018, 97(15): e0361. http://europepmc.org/abstract/MED/29642182
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(5)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (205) PDF downloads(7) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return