Volume 19 Issue 3
Mar.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(3): 354-357,462
SONG Yang, XIA Bing, WU Yue-guang. Analysis of related clinical risk factors of lung infection in patients with lung cancer[J]. Chinese Journal of General Practice, 2021, 19(3): 354-357,462. doi: 10.16766/j.cnki.issn.1674-4152.001808
Citation: SONG Yang, XIA Bing, WU Yue-guang. Analysis of related clinical risk factors of lung infection in patients with lung cancer[J]. Chinese Journal of General Practice, 2021, 19(3): 354-357,462. doi: 10.16766/j.cnki.issn.1674-4152.001808
shu

Analysis of related clinical risk factors of lung infection in patients with lung cancer

doi: 10.16766/j.cnki.issn.1674-4152.001808

  • Oncology Surgery, Hangzhou Cancer Hospital, Hangzhou, Zhejiang 310003, China

Funds:

 81301927

  • Received Date: 2020-06-27
    Available Online: 2022-02-19
    Abstract
  •   Objective   To explore the relevant risk factors for lung infection.   Methods   We conducted a retrospective study of 156 lung cancer patients admitted to Hangzhou Cancer Hospital from January 2014 to December 2016. Pulmonary infection was defined as a chest radiograph showing the presence of new or ongoing infiltrating lesions combined with any of the following: new purulent sputum, changes chronic sputum, or fever. Multivariate cox regression analysis was used to explore the risk factors that were significantly related to lung infection.   Results   A total of 60 cases (38.5%) of all study subjects developed pulmonary infections. Until the end of follow-up, the average overall survival rate of patients in the pneumonia group was significantly shorter than that of patients in the non-pneumonia group (48.5% vs. 74.2%, P < 0.05). The overall survival rate of smoking patients was significantly lower than that of never-smokers (32.8% vs. 19.6% vs. 75.4%, P < 0.001). Multivariate analysis showed that age (P=0.001), clinical stage Ⅳ (P=0.045), neutropenia (P < 0.001), and smoking (P=0.020) were independent risk factors for lung infection in patients with lung cancer. A subgroup analysis of patients receiving chemotherapy showed that age (P=0.006), neutral granulocytopenia (P < 0.001), smoking (P=0.030), and second-line therapy (P=0.004) were independent risk factors for the development of pneumonia.   Conclusion   For lung cancer patients, old age, smoking, and neutropenia are significant risk factors affecting their lung infections.

     

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