Volume 19 Issue 3
Mar.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(3): 383-386
RAO Min-jie, LI Yi-nan, ZHANG Gong-heng, YUAN Xiao-jun, GAN Xin-rong, XU Wen-hua, CAO Sheng-sheng. Effect of zoledronic acid combined with percutaneous vertebroplasty on osteoporotic compression fractures in the elderly patients[J]. Chinese Journal of General Practice, 2021, 19(3): 383-386. doi: 10.16766/j.cnki.issn.1674-4152.001816
Citation: RAO Min-jie, LI Yi-nan, ZHANG Gong-heng, YUAN Xiao-jun, GAN Xin-rong, XU Wen-hua, CAO Sheng-sheng. Effect of zoledronic acid combined with percutaneous vertebroplasty on osteoporotic compression fractures in the elderly patients[J]. Chinese Journal of General Practice, 2021, 19(3): 383-386. doi: 10.16766/j.cnki.issn.1674-4152.001816
shu

Effect of zoledronic acid combined with percutaneous vertebroplasty on osteoporotic compression fractures in the elderly patients

doi: 10.16766/j.cnki.issn.1674-4152.001816
  • 1.

    Department of Orthopaedics, the People's Hospital of Yichun City, Yichun, Jiangxi 336000, China

Funds:

 20197495

  • Received Date: 2020-04-26
    Available Online: 2022-02-19
    Abstract
  •   Objective  To explore the effect of zoledronic acid on bone mineral density and bone metabolism in elderly patients with osteoporotic vertebral compression fracture after vertebroplasty providing basis for clinical treatment.  Methods  From January 2019 to December 2019, a total of 92 elderly patients with osteoporotic vertebral compression fractures in the People's Hospital of Yichun City were selected, and divided into treatment group (44 cases) and control group (48 cases) according to the random number table method. All the patients in the two groups received percutaneous vertebroplasty treatment. The patients in the control group were treated with calcitriol and vitamin D after the percutaneous vertebroplasty, and the patients in the treatment group were additionally given zoledronic acid. The visual analogue scale (VAS) and Oswestry disability index score (ODI) were recorded. Bone mineral density and serum bone Gla-protein (BGP) were assessed before and after the treatment.  Results  All patients successfully completed the percutaneous vertebroplasty operation. The VAS, ODI, lumbar vertebral bone density and serum osteocalcin were not significantly different between the two groups before the treatment (all P>0.05). The VAS and ODI scores of patients in the two groups after the treatment were all improved (all P < 0.05), the difference between the two groups was statistically significant (all P < 0.05). At the last follow-up, lumbar vertebral bone density and serum osteocalcin were significantly increased in both groups (all P < 0.05), and the treatment group was significantly better than the control group (all P < 0.05).  Conclusion  The application of zoledronic acid combined with percutaneous vertebroplasty has favorable curative effect on osteoporotic vertebral compression fractures in elderly patients, and could improve the symptoms of osteoporosis, the bone density and bone metabolism indexes of patients.

     

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