Volume 19 Issue 3
Mar.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(3): 402-404,440
ZHENG Qing-rui, ZHOU Mei-yun, HAN Ying-ying, WANG Qian-qian, XU Jin-cheng. Expression of SOX6 in oral mucoepidermoid carcinoma and its clinical significance[J]. Chinese Journal of General Practice, 2021, 19(3): 402-404,440. doi: 10.16766/j.cnki.issn.1674-4152.001821
Citation: ZHENG Qing-rui, ZHOU Mei-yun, HAN Ying-ying, WANG Qian-qian, XU Jin-cheng. Expression of SOX6 in oral mucoepidermoid carcinoma and its clinical significance[J]. Chinese Journal of General Practice, 2021, 19(3): 402-404,440. doi: 10.16766/j.cnki.issn.1674-4152.001821
shu

Expression of SOX6 in oral mucoepidermoid carcinoma and its clinical significance

doi: 10.16766/j.cnki.issn.1674-4152.001821

  • Department of Stomatology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2016A480

  • Received Date: 2020-10-20
    Available Online: 2022-02-19
    Abstract
  •   Objective  To detect the expression of transcription factor sex-determining region Y-box 6 (SOX6) in mucoepidermoid carcinoma (MEC) of salivary gland and adjacent normal tissues, as well as to explore the relationship between the expression difference and clinicopathological features and prognosis of patients.  Methods  The immunohistochemical EnVision method was used to detect the expression of SOX6 protein in 55 cases of salivary gland mucoepidermoid carcinoma and the corresponding normal tissues adjacent to the cancer. The relationship between the expression of SOX6 and the clinicopathological characteristics (gender, age, pathological grade, TNM staging, and lymph-node metastasis) and prognosis of salivary gland mucoepidermoid carcinoma was analysed by statistical methods.  Results  The positive expression rate of SOX6 in mucoepidermoid carcinoma was 62.3% (37/55), and the positive expression rate of SOX6 in the corresponding normal tissues adjacent to the cancer was 36.4% (20/55). The positive expression rate of SOX6 in mucoepidermoid carcinoma was significantly higher than that of the corresponding normal tissues (P < 0.05). The difference of SOX6 expression in mucoepidermoid carcinoma was related to pathological grade and clinical stage (all P < 0.05). With decreased pathological grade of MEC patients and increased TNM stage, the expression of SOX6 increased. But there was no statistical significance between gender, age and SOX6 positive expression rate (all P>0.05). The results of statistical analysis showed that the five-year survival time of the SOX6 negative group was longer than that of the positive group, and the difference was statistically significant. The high expression of SOX6 was significantly correlated with the poor prognosis of patients (P < 0.05). SOX6 may be an independent prognostic factor in patients with mucoepidermoid carcinoma of salivary gland.  Conclusion  SOX6 is highly expressed in MEC tissues and may play an important role in the occurrence of MEC, which has certain reference value for the treatment and diagnosis of MEC.

     

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