Volume 19 Issue 3
Mar.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(3): 441-445
LIU Wen-juan, SONG Ming-fen, WANG Wei, LIU Xue-jun. Effects of repetitive transcranial magnetic stimulation combined with sertraline on depressive symptoms and related miR-expression in peripheral blood of patients with postpartum depression[J]. Chinese Journal of General Practice, 2021, 19(3): 441-445. doi: 10.16766/j.cnki.issn.1674-4152.001831
Citation: LIU Wen-juan, SONG Ming-fen, WANG Wei, LIU Xue-jun. Effects of repetitive transcranial magnetic stimulation combined with sertraline on depressive symptoms and related miR-expression in peripheral blood of patients with postpartum depression[J]. Chinese Journal of General Practice, 2021, 19(3): 441-445. doi: 10.16766/j.cnki.issn.1674-4152.001831
shu

Effects of repetitive transcranial magnetic stimulation combined with sertraline on depressive symptoms and related miR-expression in peripheral blood of patients with postpartum depression

doi: 10.16766/j.cnki.issn.1674-4152.001831

  • Department of Clinical Psychology, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang 310013, China

Funds:

 81601183

  • Received Date: 2020-03-24
    Available Online: 2022-02-19
    Abstract
  •   Objective  To investigate the effects of repeated transcranial magnetic stimulation combined with sertraline on the depressive symptoms and expression of peripheral blood miR-195 and miR-124 in patients with postpartum depression (PPD).  Methods  A total of 96 patients with PPD were selected from June 2017 to October 2019 in Hangzhou Seventh People's Hospital. They were divided into a combined group, control group A and control group B via a simple randomization method, 32 cases in each group. Control group A was given sertraline (50 mg/d at 1 week, which was increased to 100 mg/d after 1 week), whereas control group B was given transcranial magnetic stimulation (1 time/d, 5 times/week).The combined group was treated with repeated transcranial magnetic stimulation and sertraline. All patients were treated for 8 weeks. The efficacy and depression score (EPDS), quality of life (GQOLI-74) score, plasma miR-195 and miR-124 expressions and levels of serum neurotransmitters before and after treatment among the three groups were compared.  Results  The total effective rate of the combined group (93.75%) was significantly higher than that of control group A (71.88%) and control group B (68.75%, all P < 0.05). After 8 weeks of treatment, the plasma miR-195 expression[(0.15±0.07) ng/L] and serum NE[(23.05±4.11) ng/L], 5-HT[(239.57±12.24) ng/L], and E2[(176.98±14.13) ng/L] levels of the combined group were higher than those of control group A[0.11±0.05, (17.18±3.09)ng/L, (214.06±15.37)ng/L and (149.13±11.50) ng/L, respectively] and control group B[0.09±0.06, (16.34±3.28)ng/L, (207.81±13.62)ng/L and (145.09±12.72) ng/L, respectively]. Moreover, plasma miR-124 expressions[(0.11±0.05) ng/L] and serum P levels[(21.87±3.16) ng/L] of the combined group were lower than those of control group A[0.17±0.06 and (30.65±4.24) ng/L, respectively] and control group B[0.20±0.09 and (31.98±4.09) ng/L, all P < 0.05]. After 8 weeks of treatment, the GQOLI-74 score of the combined group was higher than that of control groups A and B, and the EPDS score was lower than that of control groups A and B (all P < 0.05).  Conclusion  Repeated transcranial magnetic stimulation combined with sertraline for the treatment of patients with PPD can regulate the levels of serum neurotransmitters, sex hormones and the expression levels of miR-195 and miR-124 in plasma, reduce the EPDS score and improve the quality of life of patients.

     

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