Volume 19 Issue 3
Mar.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(3): 449-453
WANG Xu, SONG Ge, WANG Zong-ping. The value in differentiation of renal angiomyolipoma with minimal fat and clear cell renal cell carcinoma by using CT heterogeneous degree[J]. Chinese Journal of General Practice, 2021, 19(3): 449-453. doi: 10.16766/j.cnki.issn.1674-4152.001833
Citation: WANG Xu, SONG Ge, WANG Zong-ping. The value in differentiation of renal angiomyolipoma with minimal fat and clear cell renal cell carcinoma by using CT heterogeneous degree[J]. Chinese Journal of General Practice, 2021, 19(3): 449-453. doi: 10.16766/j.cnki.issn.1674-4152.001833
shu

The value in differentiation of renal angiomyolipoma with minimal fat and clear cell renal cell carcinoma by using CT heterogeneous degree

doi: 10.16766/j.cnki.issn.1674-4152.001833
  • 1.

    Department of Radiology, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China

Funds:

 2016KYA038

  • Received Date: 2020-03-10
    Available Online: 2022-02-19
    Abstract
  •   Objective  To investigate the value of heterogeneous degree in differential diagnosis of renal angiomyolipoma with minimal fat (mfAML) and clear cell renal cell carcinoma (ccRCC).  Methods  CT scan images of mfAML (n=25) and ccRCC (n=45) confirmed by pathology in Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) were retrospectively collected and analyzed from January 2016 to October 2019. The heterogeneous degree of tumor and psoas (HDT/HDP) were measured and standardized heterogeneous rate of tumor (SHRT) was obtained. The CT value of tumor and renal cortex in each enhanced phase were measured and enhancement rate of tumor (ERT) was obtained. The difference of parameters between the two tumors were statistically analyzed. The receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic efficacy of each parameter.  Results  HDT and SHRT of cortical phase, HDT of nephrographic phase, and HDT and SHRT of excretory phase in mfAML were all lower than that in ccRCC, the difference was statistically significant (all P < 0.05). There was no statistically significant difference in HDT and SHRT of pre-contrast phase and SHRT of nephrographic phase between the two groups (all P>0.05). The CT value of pre-contrast phase in mfAML was higher than ccRCC, while the ERT of cortical phase in mfAML was lower than ccRCC, the difference was statistically significant (all P < 0.05). There was no statistically significant difference in CT value of cortical phase, CT value and ERT of nephrographic phase and CT value and ERT of excretory phase between the two tumors (all P>0.05).The ROC curve showed that the area under curve (AUC) of HDT & SHRT in cortical phase was larger, with AUC values of 0.85 and 0.82 respectively.When HDT of cortical phase took 31.31 Hu as the cutoff value, the sensitivity to distinguish these two tumors was 84.4%, and its specificity was 72.0%.  Conclusion  The heterogeneous degree can be used as a simple quantitative index to reflect the difference in enhanced homogeneity to distinguish mfAML from ccRCC, among which the diagnosis value of heterogeneous degree in cortical phase is higher.

     

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