Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 538-541, 546
CHEN Xi-xi, CHEN Gui-hai, WANG Huan, JIANG Hui, HUANG Jin, LIU Xue-sheng, LIU Xun-qin. Application of different types of sedation methods in painless induced abortion and their influence on cognition of puerpera[J]. Chinese Journal of General Practice, 2021, 19(4): 538-541, 546. doi: 10.16766/j.cnki.issn.1674-4152.001855
Citation: CHEN Xi-xi, CHEN Gui-hai, WANG Huan, JIANG Hui, HUANG Jin, LIU Xue-sheng, LIU Xun-qin. Application of different types of sedation methods in painless induced abortion and their influence on cognition of puerpera[J]. Chinese Journal of General Practice, 2021, 19(4): 538-541, 546. doi: 10.16766/j.cnki.issn.1674-4152.001855
shu

Application of different types of sedation methods in painless induced abortion and their influence on cognition of puerpera

doi: 10.16766/j.cnki.issn.1674-4152.001855
  • 1.

    Department of Anaesthesiology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China

Funds:

 81671316

  • Received Date: 2020-09-23
    Available Online: 2022-02-16
    Abstract
  •   Objective  The aim of this study is to compare the effect of propofol and etomidate alone or combination in painless artificial abortion and their influence on cognition of puerperal.  Methods  One hundred and eighty pregnant women scheduled for painless induced abortion in the First Affiliated Hospital of Anhui Medical University from January to April 2019 were randomized assigned into P (propofol), E (etomidate) and EP (etomidate combined with propofol) groups. Before leaving the operating room, the cognitive level was assessed by Montreal cognitive assessment (MoCA). The figures of systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), SpO2 were recorded before anesthesia, and after anesthesia induction, during operation and at the end of operation. The injection pain, myoclonus, hypotension, bradycardia, hypoxemia, nausea and vomiting, and other adverse reactions were recorded. The total dose, operation time, recovery time and departure time were recorded.  Results  There were no significant differences in the total score and cognitive domain index scores of MoCA among the three groups (all P>0.05). The P and PE groups obtained relatively satisfactory anesthesia, but the anesthetic effect of 4 cases in the E group was not good. There was no significant difference in SBP, DBP, MAP and HR among groups (all P>0.05), however, there was significant difference in SpO2 among different time points (all P < 0.05). There were interaction effects among groups and time points had interventions on SBP, DBP and MAP. Different interventions and different time points had significant effects on SpO2, and there was interaction (all P < 0.05). The P group had more injection pain than the E and EP and groups (all P < 0.017), the P and EP groups had more frequent hypoxemia as compared with the E group (all P < 0.017), and myoclonus and nausea and vomiting were more frequent in the E group when compared with the P and EP groups.  Conclusion  The propofol and etomidate alone or combination had similar short-term effect on cognition, the combination of propofol and etomidate had the best anesthetic effective in painless abortion, however, etomidate alone had the best safety.

     

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